Articleposted 2024-08-14 01:19:01
Sable: Bridging the Gap in Protein Structure Understanding with an Empowering and Versatile Pre-training Paradigm
Qiwei Ye, jiashan li, Xi Chen, He Huang, Mingliang Zeng, Jingcheng Yu, Xinqi Gong
Under Review
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Articleposted 2024-07-29 01:21:54
Accurate single domain scaffolding of three non-overlapping protein epitopes using deep learning
Bruno Correia, Karla Castro, Joseph Watson, Jue Wang, Joshua Southern, Reyhaneh Ayardulabi, Sandrine Georgeon, and 2 more authors
Under Review
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Biological Sciences - Articleposted 2024-07-01 03:07:12
InstructPLM: Aligning Protein Language Models to Follow Protein Structure Instructions
Jiezhong Qiu, Junde Xu, Jie Hu, Hanqun Cao, Liya Hou, Zijun Gao, Xinyi Zhou, and 15 more authors
Under Review
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Articleposted 2024-01-16 11:15:37
Ensemble-based design of tau to inhibit aggregation while preserving biological activity
Lukasz Joachimiak, Sofia Bali, Ruhar Singh, Pawel Wydorski, Aleksandra Wosztyl, Valerie Perez, Dailu Chen, and 1 more authors
Under Revision
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Biological Sciences - Articleposted 2023-11-10 13:53:56
Sequence-ensemble-function relationships for disordered proteins in live cells
Alex Holehouse, Ryan Emenecker, Karina Guadalupe, Nora Shamoon, Shahar Sukenik
Posted
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Articleposted 2023-10-26 20:20:36
Computational design of highly signaling active membrane receptors through de novo solvent-mediated allosteric networks
Kuang-Yui Chen, Jason Lai, Jing Wang, Anna Maria Russell, Kris Conners, Marc Edward Rutter, Bradley Condon, and 8 more authors
Under Review
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Articleposted 2023-09-27 02:39:32
Highly accurate and robust protein sequence design with CarbonDesign
Haicang Zhang, Milong Ren, Chungong Yu, Dongbo Bu
Published
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Biological Sciences - Articleupdated 2023-09-11 16:45:56
Complete Combinatorial Mutational Enumeration of a protein functional site enables sequence-landscape mapping and identifies highly-mutated variants that retain activity
Mireia Solà Colom, Jelena Vucinic, Jared Adolf-Bryfogle, James W. Bowman, Sébastien Verel, Isabelle Moczygemba, Thomas Schiex, and 2 more authors
Published
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Biological Sciences - Articleposted 2023-07-10 04:43:22
Hierarchical design of pseudosymmetric protein nanoparticles
David Baker, Quinton Dowling, Young-Jun Park, Neil Gerstenmaier, Erin Yang, Adam Wargacki, Yang Hsia, and 6 more authors
Under Review
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Articleposted 2023-05-17 05:20:44
Development of Evolutionally Algorithm-Based Protein Redesign Method
Hiroki Ozawa, Ibuki Unno, Ryohei Sekine, Sohei Ito, Shogo Nakano
Posted
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