Jianbao Li[16] | 2014 | China | 45 | 45 | 25(55.5) | 21(46.6) | 55.47 ± 13.32 | 52.58 ± 14.21 | N/A | N/A | TXA: 15 mg/kg, tid, intravenous drip. Rivoraxaban: 10 mg/day, orally. | Rivoraxaban: 10 mg/day, orally. | THA | 14 days | TBL, BTV, BTR, IBL, Postoperation drainage, APTT, PT, Hb |
Guokuan Xing[17] | 2015 | China | 60 | 60 | 42(70.0) | 46(76.6) | 70.34 ± 7.41 | 69.32 ± 7.21 | 27.3 | 26.7 | TXA: 1.5 g, intraarticular injection; 1.0 g local perfusion. Rivoraxaban: 15 mg/day, orally. | LMWH: 2 500 AXa IU /d, hypodermic injection. | TKA | 3 months | TBL, HBL, BTV, BTR, FG, APTT, MB, NMB, Hb |
Junwen Wang[18] | 2016 | China | 100 | 98 | 74(74.0) | 72(77.6) | 68.19 | 69.60 | 28.2 | 28.1 | TXA: 1.0 g, intraoperative injection. Rivoraxaban: 10 mg/day, orally. | Rivoraxaban: 10 mg/day, orally. | TKA | 3 months | TBL, HBL, BTR, Postoperation drainage, NMB |
Fulin Li a[19] | 2017 | China | 30 | 30 | 7(23.3) | 10(33.3) | 62.20 ± 6.60 | 62.20 ± 7.30 | 21.8 | 21.3 | TXA: 10 mg/kg before skin incision, intravenous drip. Rivoraxaban: 10 mg/day, orally. | 100 ml 0.9% NS, intravenous drip | THA | 3 months | APTT, PT |
Fulin Li b[19] | 2017 | China | 30 | 30 | 8(26.7) | 10(33.3) | 62.70 ± 6.50 | 62.20 ± 7.30 | 21.4 | 21.3 | TXA: 15 mg/kg, before skin incision, intravenous drip. Rivoraxaban: 10 mg/day, orally. | 100 ml 0.9% NS: intravenous drip. | THA | 3 months | APTT, PT |
Fulin Li c[19] | 2017 | China | 30 | 30 | 9(30.0) | 10(33.3) | 61.80 ± 13.00 | 62.20 ± 7.30 | 21.1 | 21.3 | TXA: 15 mg/kg, before skin incision and after 3 h, intravenous drip. Rivoraxaban: 10 mg/day, orally. | 100 ml 0.9% NS: intravenous drip. | THA | 3 months | HBL, Postoperation drainage, APTT, PT |
Fulin Li d[19] | 2017 | China | 30 | 30 | 8(26.7) | 10(33.3) | 62.40 ± 7.40 | 62.20 ± 7.30 | 21.4 | 21.3 | TXA: 15 mg/kg, before skin incision, intravenous drip; 1.0 g, local wet compress. Rivoraxaban: 10 mg/day, orally. | 100 ml 0.9% NS: intravenous drip. | THA | 3 months | APTT, PT |
Guokuan Xing[20] | 2017 | China | 50 | 50 | 36(72.0) | 38(76.0) | 61.40 ± 6.60 | 63.10 ± 3.80 | 26.3 | 27.4 | TXA: 1.0 g, intravenous drip; 1.0 g, local perfusion. Rivoraxaban: 15 mg/day, orally. | LMWH: 2 500 AXa IU /d, hypodermic injection. | TKA | 3 months | TBL, BTV, BTR, IBL, Postoperation drainage, NMB, Hb |
Hongjian Xu[21] | 2017 | China | 75 | 75 | 35(46.6) | 34(45.3) | 65.18 ± 3.32 | 65.22 ± 3.28 | N/A | N/A | TXA: 1.0 g, local wet compress. Rivoraxaban: 10 mg/day, orally. | LMWH: 0.01 ml/kg, q12h, hypodermic injection. | THA | 6 months | TBL, HBL,BTV, BTR, FG, APTT, MB, NMB |
Jinwei Xie[22] | 2017 | China | 96 | 98 | 74(96.0) | 86(98.0) | 65.20 ± 5.50 | 66.80 ± 7.40 | 25.4 | 25.6 | TXA: 15 mg/kg, intravenous before tourniquet deflation; 1.0 g, injected into the articular cavity through the drainage tube. Rivoraxaban: 10 mg/day, orally. | TXA: 15 mg/kg, intravenous before tourniquet deflation; 1.0 g, injected into the articular cavity through the drainage tube. LMWH: 0.4 ml 4000 IU, hypodermic injection. | TKA | 3 months | TBL, HBL, BTR, Postoperation drainage, APTT, PT, MB, NMB |
Keming Xia a[23] | 2017 | China | 49 | 49 | N/A | N/A | 66.00 ± 10.40 | 62.40 ± 11.30 | 25.4 ± 3.9 | 25.4 ± 3.3 | TXA: 10 mg/kg,0.5 h before operation, intravenous. Rivoraxaban: 10 mg/day, orally. | Rivoraxaban: 10 mg/day, orally. | TKA | 2 weeks | TBL, HBL, BTR, IBL, Postoperation drainage, Hb |
Keming Xia b[23] | 2017 | China | 49 | 49 | N/A | N/A | 64.10 ± 9.20 | 62.40 ± 11.30 | 25.9 ± 4.1 | 25.4 ± 3.3 | TXA: 10 mg/kg,0.5 h before operation, intravenous; 50 ml, local injection after operation. Rivoraxaban: 10 mg/day, orally. | Rivoraxaban: 10 mg/day, orally. | TKA | 2 weeks | TBL, HBL, BTR, IBL, Postoperation drainage, Hb |
Shih-Hsiang Yen a[24] | 2017 | China | 31 | 30 | 27(87.1) | 24(80.0) | 69.13 | 70.87 | 28.4 | 28.3 | TXA: 1.0 g, intraoperative bolus injection. Rivoraxaban: 10 mg/day, orally. | Rivoraxaban: 10 mg/day, orally. | TKA | 12 weeks | TBL, BTR, Postoperation drainage, NMB |
Shih-Hsiang Yen b[24] | 2017 | China | 32 | 30 | 19(59.4) | 24(80.0) | 69.66 | 70.87 | 28.1 | 28.3 | TXA:3.0 g, intraarticular injection. Rivoraxaban:10 mg/day, orally. | Rivoraxaban: 10 mg/day, orally. | TKA | 12 weeks | TBL, BTR, Postoperation drainage, NMB |
Weina Zhou[25] | 2017 | China | 33 | 33 | N/A | N/A | 66.30 ± 7.40 | 66.30 ± 7.40 | 23.9 | 23.9 | TXA:1.0 g, intraarticular injection. Rivoraxaban:15 mg/day, orally. | TXA:1.0 g intraarticular injection. LMWH: 2500 IU /d, hypodermic injection. | THA | 14 days | HBL, BTV, IBL, FG, APTT, PT |
Yanmei Fan[26] | 2017 | China | 65 | 65 | N/A | N/A | 60 ~ 87 | 60 ~ 87 | N/A | N/A | TXA: 0.5 g, local wet compress. Rivoraxaban: 10 mg/day, orally. | Rivoraxaban: 10 mg/day, orally. | TKA | 6 months | TBL,HBL, BTV, BTR, IBL, |
Yanan Fan[27] | 2017 | China | 30 | 30 | 13(43.3) | 10(33.3) | 57.03 ± 10.23 | 55.55 ± 7.11 | 22.8 ± 2.7 | 23.4 ± 3.5 | TXA: 1.0 g, preoperative intravenous drip;100 ml, after sewing. Rivoraxaban: 10 mg/day, orally. | TXA: 1.0 g, preoperative intravenous drip;100 ml, after sewing. LMWH: drug administration as appropriate | THA | 3 months | TBL, BTR, Postoperation drainage, APTT, PT |
Fang Lan a[28] | 2018 | China | 70 | 78 | 37(52.9) | 46(58.9) | 62.50 ± 15.40 | 63.70 ± 11.90 | N/A | N/A | TXA: 10 mg/kg (preoperative intravenous drip) 10 mg/kg (postoperative intravenous drip) Rivoraxaban: 10 mg/day, orally. | 250 ml 0.9% NS: intravenous drip. | TKA | 1 months | HBL, BTR, IBL, Postoperation drainage |
Fang Lan b[28] | 2018 | China | 92 | 78 | 54(58.7) | 46(58.9) | 64.40 ± 12.60 | 63.70 ± 11.90 | N/A | N/A | TXA: 2.0 g, intraarticular injection. Rivoraxaban: 10 mg/day, orally. | 250 ml 0.9% NS: intravenous drip. | TKA | 1 months | HBL, BTR, IBL, Postoperation drainage |
Wen Li[29] | 2018 | China | 33 | 33 | 13(44.2) | 16(48.5) | 67.80 ± 7.20 | 68.50 ± 7.80 | N/A | N/A | TXA: 1.0 g, intraarticular injection. Rivoraxaban: 10 mg/day, orally. | Rivoraxaban: 10 mg/day, orally. | TKA | 15 days | TBL, HBL, BTV, BTR, FG, APTT |
Xingjing Wu[30] | 2018 | China | 73 | 73 | N/A | N/A | ༞60 | ༞60 | N/A | N/A | TXA: 2.0 g, intraarticular injection. Rivoraxaban: 10 mg/day, orally. | Rivoraxaban: 10 mg/day, orally. | THA | 6 months | TBL, BTR, IBL, Postoperation drainage, PT, Hb |
A. Clavé a[12] | 2019 | France | 76 | 75 | 45(59.2) | 42(56.0) | 65.00 | 64.40 | 27.5 | 26.6 | TXA: 1.0 g, intravenous injection, at 0 hour and postoperative hour 3. Rivoraxaban: 10 mg/day, orally. | Rivoraxaban: 10 mg/day, orally. | THA | 3 months | TBL, MB, NMB |
A. Clavé b[12] | 2019 | France | 78 | 75 | 44(56.4) | 42(56.0) | 67.10 | 64.40 | 25.3 | 26.6 | TXA: 1.0 g, intravenous injection, at 0 hour and postoperative hours 3, 7, and 11. Rivoraxaban: 10 mg/day, orally. | Rivoraxaban: 10 mg/day, orally. | THA | 3 months | TBL, MB, NMB |