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Comparing the effects of dezocine with lidocaine on prevention of propofol injection pain in adults: a prospective randomized double-blind trial

Xuqin Zhu, Songlin Jia, Yajun Xu, Zhirong Sun
DOI: 10.21203/rs.2.9717/v2

Abstract

Abstract Background: Propofol injection pain (PIP) is common and may decrease patient comfort. The aim of this study was to compare the effects of dezocine with lidocaine on prevention of PIP. Methods: 235 patients, who scheduled for elective surgery, aged 18-80 years and ASA (American Society of Anesthesiologists) I or II, were randomly assigned into five groups (n = 47 each). All patients were induced through the dor­sal hand vein or antecubital vein. The five groups were given the following medication intravenously: saline (Group I), lidocaine 20 mg (Group II), lidocaine 40 mg (Group III), dezocine 2 mg (Group IV) and dezocine 4 mg (Group V). Twenty seconds later all patients received a propofol infusion and were asked to grade pain or discomfort in the hand or forearm according to a four-point scale until anesthesia. Results: Three groups showed a significantly lower incidence of total PIP than Group Ⅰ: Group III (OR (Odds ratio): 0.39 (0.16, 0.93)); Group IV (OR: 0.21 (0.09, 0.51)) and Group V (OR: 0.12 (0.05, 0.30)). Group Ⅳ showed a significantly lower incidence of total PIP than Group Ⅱ (OR: 0.32 (0.13, 0.77)). Group Ⅴ showed a significantly lower incidence of total PIP than Group Ⅱ (OR: 0.15 (0.06, 0.39)) or Group Ⅲ (OR: 0.30 (0.13, 0.72)). Conclusion: Dezocine is a novel agent to alleviate PIP and appears to some extent to be more effective than lidocaine.

Keywords
Dezocine, Lidocaine, Propofol injection pain

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Preprint: Please note that this article has not completed peer review.

Comparing the effects of dezocine with lidocaine on prevention of propofol injection pain in adults: a prospective randomized double-blind trial

Xuqin Zhu, Songlin Jia, Yajun Xu, Zhirong Sun

STATUS: In Review

Comments: 0
PDF Downloads: 0
HTML Views: 16

Integrity Check:

  • Article

  • Peer Review Timeline

  • Related Articles

  • Comments

Abstract

Abstract Background: Propofol injection pain (PIP) is common and may decrease patient comfort. The aim of this study was to compare the effects of dezocine with lidocaine on prevention of PIP. Methods: 235 patients, who scheduled for elective surgery, aged 18-80 years and ASA (American Society of Anesthesiologists) I or II, were randomly assigned into five groups (n = 47 each). All patients were induced through the dor­sal hand vein or antecubital vein. The five groups were given the following medication intravenously: saline (Group I), lidocaine 20 mg (Group II), lidocaine 40 mg (Group III), dezocine 2 mg (Group IV) and dezocine 4 mg (Group V). Twenty seconds later all patients received a propofol infusion and were asked to grade pain or discomfort in the hand or forearm according to a four-point scale until anesthesia. Results: Three groups showed a significantly lower incidence of total PIP than Group Ⅰ: Group III (OR (Odds ratio): 0.39 (0.16, 0.93)); Group IV (OR: 0.21 (0.09, 0.51)) and Group V (OR: 0.12 (0.05, 0.30)). Group Ⅳ showed a significantly lower incidence of total PIP than Group Ⅱ (OR: 0.32 (0.13, 0.77)). Group Ⅴ showed a significantly lower incidence of total PIP than Group Ⅱ (OR: 0.15 (0.06, 0.39)) or Group Ⅲ (OR: 0.30 (0.13, 0.72)). Conclusion: Dezocine is a novel agent to alleviate PIP and appears to some extent to be more effective than lidocaine.

Figures

Background

Methods

Results

Discussion

Conclusions

List of abbreviations

Declarations

References

Tables

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