Background: Claudin’s gene are associated with various aberrant physiological and cellular signaling. However, the association of claudins with survival prognosis, signaling pathways, and diagnostic efficacy in colon cancer remain lacking.
Methods: We used various bioinformatics methods, including differential expression analysis, gene set enrichment analysis (GSEA), protein-protein interaction (PPI), survival analysis, single sample gene set enrichment analysis (ssGSEA), mutation analysis, and identifying receiver operating characteristic (ROC) curve of claudins in the TCGA colon adenocarcinoma (COAD).
Results: We found that: CLDN2, CLDN1, CLDN14, CLDN16, CLDN18, CLDN9, CLDN12, and CLDN6 are elevated in COAD. In contrast, the CLDN8, CLDN23, CLDN5, CLDN11, CLDN7, and CLDN15 are downregulated in COAD. Various claudin’s genes are mutated and associated with diagnostic efficacy in the COAD.
Conclusions: Claudin’s genes are associated with prognosis, immune regulation, signaling pathway regulations, and diagnosis. These findings may provide new molecular insight into the treatment of colon cancer.