Pregnancy loss and infertility affect one in six couples, and better understanding of the underlying mechanisms is needed for treatment. A good place to start is embryo implantation -- the first step of pregnancy. Unfortunately, few studies have evaluated the mechanisms affecting embryo implantation potential. A new study evaluated the signaling mechanisms behind a cell polarization process called epithelial-mesenchymal transition (EMT). EMT directs both the formation of the placenta by trophoblast cells and cell differentiation in the developing embryo. Researchers evaluated embryo implantation in wild-type mice and mice lacking components of the Wnt/β-catenin-lin28a signaling pathway. Their results showed that active β-catenin was present in the pre-implantation embryonic membrane, and silencing Wnt/β-catenin signaling reduced the embryo implantation rate. Let-7, a microRNA that regulates epithelial cells, reduced embryonic potential, while Wnt signaling blocked this effect, and the Let-7 inhibitor Lin28a promoted embryonic potential, driven by Wnt signaling. This suggests a mechanism whereby Wnt/β-catenin upregulates Lin28a and downregulates let-7 to promote embryo implantation. Although more mechanistic details remain to be uncovered, the results suggest that targeting EMT-related signaling will help to promote embryo implantation, offering a novel therapeutic avenue for treating infertility and pregnancy loss.