Population
Ten patients with TBI (7 males), aged–35-60 years, were included, and the time since injury ranged from 22 to 733 days. Five healthy controls (2 males; mean age 52.5 y) without any history of prior neurological diseases were also recruited (Table 1). When reassessed at 3 months, 5 patients appeared to be in UWS, as demonstrated by sustained unconsciousness with an average CRS-R score of 3.6 (UWS group; 4 men and 1 woman), and the other 5 patients regained signs of consciousness with an average CRS-R score of 21.6 (RC group; 3 males and 2 females)[14]. Detailed information about the patients’ clinical data and CRS-R scores are presented in Table 1.
Differential analysis of proteome
We investigated the proteome profile in the CSF of healthy subjects, patients in the RC group, and in the UWS group using two-dimensional electrophoresis and gel-based proteomics technology. There were at least six protein spots (spots 1, 3, 4, 5, 7, and 8) expressed at higher levels and two protein spots (spots 2 and 6) expressed at lower levels on the gel of CSF from the RC group. These protein spots for the control, RC, and UWS groups are shown in Figure 2A.
Identification of differently expressed proteins
MALDI-TOF-MS was used to identify the differentially expressed proteins. Eight proteins were detected: vitamin D-binding protein (VDP), coenzyme Q-binding protein COQ10 homolog A (COQ10A), apolipoprotein A-IV (Apo A-IV), transthyretin (TTR), zinc finger BED domain-containing protein 1 (ZBED1), DNA replication licensing factor MCM4 (MCM4), keratin type II cytoskeletal 1 (Krt1), and hemoglobin subunit beta (HGβ). Detailed information regarding these proteins is provided in Table 2. The available proteins were compared among the three groups (Table 3).
Table 2
Information about the differently expressed proteins in the CSF
POS
|
Protein name
|
Mr
|
pI
|
Database Number
|
1
|
Vitamin D-binding protein
|
52929
|
5.4
|
sp|P02774|VTDB_HUMAN
|
2
|
Coenzyme Q-binding protein COQ10 homolog A, mitochondria
|
27668.1
|
9.81
|
sp|Q96MF6|CQ10A_HUMAN
|
3
|
Apolipoprotein A-IV
|
45371.5
|
5.28
|
sp|P06727|APOA4_HUMAN
|
4
|
Transthyretin
|
15877
|
5.52
|
sp|P02766|TTHY_HUMAN
|
5
|
Zinc finger BED domain-containing protein 1
|
78105.6
|
5.79
|
sp|O96006|ZBED1_HUMAN
|
6
|
DNA replication licensing factor MCM4
|
96497.6
|
6.28
|
sp|P33991|MCM4_HUMAN
|
7
|
Keratin, type II cytoskeletal 1
|
65999
|
8.15
|
sp|P04264|K2C1_HUMAN
|
8
|
Hemoglobin subunit beta
|
15988.3
|
6.75
|
sp|P68871|HBB_HUMAN
|
POS: position of series; Mr: Relative molecular mass; pI: isoelectric point; CSF: Cerebrospinal fluid
Table 3. Comparison of the eight proteins among the three inter-groups
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)
UWS: unresponsive wakefulness syndrome; RC: regained consciousness
As shown in Figure 2B and Figure 3, compared to the healthy control group, the expression of VDP, Apo A-IV, TTR, ZBED1, Krt1, and HGβ increased in the RC group by 2.25-fold, 3.29-fold, 8.24-fold, 4.24-fold, 8.9-fold, and 7.39-fold, respectively. In contrast, levels of COQ10A and MCM4 were 4.31-fold lower and 2.54-fold lower in the RC group than in the control group, respectively. To explore the potential biomarkers that may indicate the consciousness status or evaluation of therapeutic efficacy in UWS patients, we further analyzed the expression of these differentially expressed proteins in the UWS group. As shown in Figure 2B and Figure 3, the expression of VDP showed a further increase as high as 4.52-fold in the UWS group compared to the healthy group, and the expression of the other up-regulated proteins demonstrated a 1.55-fold decrease in Apo A-IV, 3.51-fold in TTR, 2.37-fold in ZBED1, and 1.22-fold in Krt1. The expression of HGβ was reversed to as low as -8.34-fold in the UWS group. In addition, levels of COQ10A increased 1.51-fold in the UWS group compared to the control group, although it was 4.31-fold lower in the RC group than in the control group. Finally, based on the 2.54-fold downregulation in the RC group, the expression of MCM4 showed a further reduction of -20.61-fold in UWS patients (Figures 2B and 3). Taken together, the three differentially expressed proteins, VDP, MCM4, and HGβ, may be involved in not only brain injury, but also consciousness maintenance.