The adaptive fixed-time control problem for nonlinear systems with time-varying actuator faults is investigated in this paper. A novel adaptive fixed-time controller is designed via combining the Lyapunov stability theory with the backstepping method. It can be adapted to both system uncertainties and unknown actuator faults. Compared with the existing fault-tolerant control schemes subject to actuator faults, the adaptive fixed-time neural networks control scheme can make sure that the tracking error is convergent in a small neighborhood of the origin within a fixed-time interval, and it does not depend on the original states of the system and actuator faults. In light of the control scheme proposed in this paper, the fixed-time stability of the closed-loop system can be guaranteed by theoretical analysis, and a numerical example is provided to verify the effectiveness of obtained theoretical results.