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Association between gastric content fluidity and pars oesophageal ulcers in nursery pigs: a cross-sectional study of high-risk Danish herds using commercial feed ad libitum
Anni Øyan Pedersen
University of Copenhagen
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at Porcine Health Management.
Background: The objective of this cross-sectional study was to assess the within-herd prevalence of pars oesophageal ulcers (POU) in high-risk Danish herds using commercial diets fed ad libitum. Furthermore, we aimed to estimate the association between gastric content fluidity and POU using a generalised additive model (GAM). The study included 200 clinically healthy nursery pigs randomly selected from ten farms (20 pigs from each farm). The 10 farms were selected based on a suspected high prevalence of gastric ulcers. Post-mortem gastric ulcer assessment was based on macroscopic lesions, and gastric content fluidity was assessed based on the solid particle sedimentation percentage (solid phase).
Results: We observed an overall prevalence of 35.5% for POU in nursery pigs. Within-herd prevalence varied considerably among farms, with values ranging from 0% in Farm 1 to 84% in Farm 4. Our model showed strong associations between POU and gastric content fluidity (P<0.001), as well as between POU and farm of origin (P<0.001). In addition, we observed that the risk of POU decreased non-linearly as the gastric content solid phase percentage increased, i.e. as the gastric content became more solid.
Conclusion: We have demonstrated that pars oesophageal ulcers are present in Danish herds with nursery pigs fed commercial diets ad libitum. Furthermore, we have established that gastric content fluidity is strongly associated with POU in nursery pigs. Even so, we cannot conclude that gastric content fluidity is solely responsible for POU. Future research should look into the association between pars oesophageal ulcers and both farm management activities and individual pig factors.
Keywords
Gastric ulcer, Pars oesophagea, Nursery pig, Risk factor, Gastric content, solid phase, Ad libitum feeding.
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
- gamanalysis.R
Additional file 1: Statistical GAM model (R file).
- 4
Additional file 2: Raw data for the statistical GAM model.
- 4
Additional file 2: Raw data for the statistical GAM model.
- supplement2
Additional file 2: Raw data for the statistical GAM model.
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On 14 Jan, 2021
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On 14 Jan, 2021
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On 14 Jan, 2021
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Posted 06 Nov, 2020
Published
On 23 Feb, 2021
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Review #1 received
Received 23 Nov, 2020
Editorial decision: Minor revision
On 23 Nov, 2020
Review #2 received
Received 12 Nov, 2020
Reviewer #2 agreed
On 06 Nov, 2020
Reviewers invited
Invitations sent on 02 Nov, 2020
Reviewer #1 agreed
On 02 Nov, 2020
Editor assigned
On 01 Nov, 2020
Submission checks complete
On 01 Nov, 2020
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On 01 Nov, 2020
First submitted
On 29 Oct, 2020
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Animal Science
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This preprint is under consideration at Porcine Health Management. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Association between gastric content fluidity and pars oesophageal ulcers in nursery pigs: a cross-sectional study of high-risk Danish herds using commercial feed ad libitum
Anni Øyan Pedersen
University of Copenhagen
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version (no preprint)
Posted 14 Jan, 2021
Editor assigned
On 14 Jan, 2021
Editorial decision: Minor revision
On 14 Jan, 2021
Submission checks complete
On 14 Jan, 2021
Editor invited
On 14 Jan, 2021
This version was not preprinted
Version 1
Posted 06 Nov, 2020
Published
On 23 Feb, 2021
No community comments so far
Review #1 received
Received 23 Nov, 2020
Editorial decision: Minor revision
On 23 Nov, 2020
Review #2 received
Received 12 Nov, 2020
Reviewer #2 agreed
On 06 Nov, 2020
Reviewers invited
Invitations sent on 02 Nov, 2020
Reviewer #1 agreed
On 02 Nov, 2020
Editor assigned
On 01 Nov, 2020
Submission checks complete
On 01 Nov, 2020
Editor invited
On 01 Nov, 2020
First submitted
On 29 Oct, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Animal Science
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at Porcine Health Management.
Background: The objective of this cross-sectional study was to assess the within-herd prevalence of pars oesophageal ulcers (POU) in high-risk Danish herds using commercial diets fed ad libitum. Furthermore, we aimed to estimate the association between gastric content fluidity and POU using a generalised additive model (GAM). The study included 200 clinically healthy nursery pigs randomly selected from ten farms (20 pigs from each farm). The 10 farms were selected based on a suspected high prevalence of gastric ulcers. Post-mortem gastric ulcer assessment was based on macroscopic lesions, and gastric content fluidity was assessed based on the solid particle sedimentation percentage (solid phase).
Results: We observed an overall prevalence of 35.5% for POU in nursery pigs. Within-herd prevalence varied considerably among farms, with values ranging from 0% in Farm 1 to 84% in Farm 4. Our model showed strong associations between POU and gastric content fluidity (P<0.001), as well as between POU and farm of origin (P<0.001). In addition, we observed that the risk of POU decreased non-linearly as the gastric content solid phase percentage increased, i.e. as the gastric content became more solid.
Conclusion: We have demonstrated that pars oesophageal ulcers are present in Danish herds with nursery pigs fed commercial diets ad libitum. Furthermore, we have established that gastric content fluidity is strongly associated with POU in nursery pigs. Even so, we cannot conclude that gastric content fluidity is solely responsible for POU. Future research should look into the association between pars oesophageal ulcers and both farm management activities and individual pig factors.
Figure 1