1. Jacob JA (2016) New sepsis diagnostic guidelines shift focus to organ dysfunction. JAMA 315:739-740. https://doi.org/10.1001/jama.2016.0736
2. Königsrainer I, Türck MH, Eisner F, Meile T, Hoffmann J, Küper M, Zieker D, & Glatzle J (2011) The gut is not only the target but a source of inflammatory mediators inhibiting gastrointestinal motility during sepsis. Cell Physiol Biochem 28(4):753–760. https://doi.org/10.1159/000335769
3. Overhaus M, To¨gel S, Pezzone MA and Bauer AJ (2004) Mechanisms of polymicrobial sepsis-induced ileus. Am J Physiol Gastrointest Liver Physiol, 287:G685-694. https://doi.org/10.1152/ajpgi.00359.2003
4. Furness JB, Callaghan BP, Rivera LR and Cho H-J (2014) The enteric nervous system and gastrointestinal innervation: integrated local and central control. Adv Exp Med Biol 817:39-71. https://doi.org/10.1007/978-1-4939-0897-4_3
5. Reichardt F, Chassaing B, Nezami BG, Li G, Tabatabavakili S, Mwangi S, Uppal K, Liang B, Vijay-Kumar M, Jones D, Gewirtz AT and Srinivasan S (2017) Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid- and lipopolysaccharide-induced TLR4 signaling. J Physiol 595:1831-1846. https://doi.org/10.1113/JP273269
6. White JP, Xiong S, Malvin NP, Khoury-Hanold W, Heuckeroth RO, Stappenbeck TS and Diamond MS (2018) Intestinal dysmotility syndromes following systemic infection by flaviviruses. Cell 175:1198-1212 e12. https://doi.org/10.1016/j.cell.2018.08.069
7. Le Berre-Scoul C, Chevalier J, Oleynikova E, Cossais F, Talon S, Neunlist M and Boudin H (2017) A novel enteric neuron-glia coculture system reveals the role of glia in neuronal development. The Journal of Physiology 595:583-598. https://doi.org/10.1113/JP271989
8. Turco F, Sarnelli G, Cirillo C, Palumbo I, De Giorgi F, D'Alessandro A, Cammarota M, Giuliano M and Cuomo R (2014) Enteroglial-derived S100B protein integrates bacteria-induced Toll-like receptor signalling in human enteric glial cells. Gut 63:105-15. https://doi.org/10.1136/gutjnl-2012-302090
9. von Boyen GB, Schulte N, Pfluger C, Spaniol U, Hartmann C and Steinkamp M (2011) Distribution of enteric glia and GDNF during gut inflammation. BMC Gastroenterol 11:3. https://doi.org/10.1186/1471-230X-11-3
10. Coelho-Aguiar Jde M, Bon-Frauches AC, Gomes AL, Verissimo CP, Aguiar DP, Matias D, Thomasi BB, Gomes AS, Brito GA and Moura-Neto V (2015) The enteric glia: identity and functions. Glia 63:921-35. https://doi.org/10.1002/glia.22795
11. Xiao W, Wang W, Chen W, Sun L, Li X, Zhang C and Yang H (2014) GDNF is involved in the barrier-inducing effect of enteric glial cells on intestinal epithelial cells under acute ischemia reperfusion stimulation. Mol Neurobiol 50:274-89. https://doi.org/10.1007/s12035-014-8730-9
12. McKeown SJ, Mohsenipour M, Bergner AJ, Young HM and Stamp LA (2017) Exposure to GDNF enhances the ability of enteric neural progenitors to generate an enteric nervous system. Stem Cell Reports 8:476-488. https://doi.org/10.1016/j.stemcr.2016.12.013
13. Brown IA, McClain JL, Watson RE, Patel BA and Gulbransen BD (2016) Enteric glia mediate neuron death in colitis through purinergic pathways that require connexin-43 and nitric oxide. Cell Mol Gastroenterol Hepatol 2:77-91. https://doi.org/10.1016/j.jcmgh.2015.08.007
14. Coquenlorge S, Duchalais E, Chevalier J, Cossais F, Rolli-Derkinderen M and M. N (2014) Modulation of lipopolysaccharide-induced neuronal response by activation of the enteric nervous system. J Neuroinflammation 11:202. https://doi.org/10.1186/s12974-014-0202-7
15. da Cunha Franceschi R, Nardin P, Machado CV, Tortorelli LS, Martinez-Pereira MA, Zanotto C, Goncalves CA and Zancan DM (2017) Enteric glial reactivity to systemic LPS administration: Changes in GFAP and S100B protein. Neurosci Res 119:15-23. https://doi.org/10.1016/j.neures.2016.12.005
16. Nasser Y, Fernandez E, Keenan CM, Ho W, Oland LD, Tibbles LA, Schemann M, MacNaughton WK, Ruhl A and Sharkey KA (2006) Role of enteric glia in intestinal physiology: effects of the gliotoxin fluorocitrate on motor and secretory function. Am J Physiol Gastrointest Liver Physiol 291:G912-27. https://doi.org/10.1152/ajpgi.00067.2006.
17. McClain J, Grubisic V, Fried D, Gomez-Suarez RA, Leinninger GM, Sevigny J, Parpura V and Gulbransen BD (2014) Ca2+ responses in enteric glia are mediated by connexin-43 hemichannels and modulate colonic transit in mice. Gastroenterology 146:497-507 e1. https://doi.org/10.1053/j.gastro.2013.10.061
18. Nagakura Y, Naitoh Y, Kamato T, Yamano M and Miyata K (1996) Compounds possessing 5-HT3 receptor antagonistic activity inhibit intestinal propulsion in mice. Eur J Pharmacol 311:67-72. https://doi.org/10.1016/0014-2999(96)00403-7
19. Swaminathan M, Hill-Yardin E, Ellis M, Zygorodimos M, Johnston LA, Gwynne RM and Bornstein JC (2016) Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice. J Vis Exp:53828. https://doi.org/10.3791/53828
20. Smith TH, Ngwainmbi J, Grider JR, Dewey WL and Akbarali HI (2013) An In-vitro Preparation of Isolated Enteric Neurons and Glia from the Myenteric Plexus of the Adult Mouse. Journal of Visualized https://doi.org/10.3791/50688
21. D'Errico F, Goverse G, Dai Y, Wu W, Stakenborg M, Labeeuw E, De Simone V, Verstockt B, Gomez-Pinilla PJ, Warner M, Di Leo A, Matteoli G and Gustafsson JA (2018) Estrogen receptor beta controls proliferation of enteric glia and differentiation of neurons in the myenteric plexus after damage. Proc Natl Acad Sci U S A 115:5798-5803. https://doi.org/10.1073/pnas.1720267115
22. von Boyen GB, Steinkamp M, Reinshagen M, Schafer KH, Adler G and Kirsch J (2004) Proinflammatory cytokines increase glial fibrillary acidic protein expression in enteric glia. Gut 53:222-8. https://doi.org/10.1136/gut.2003.012625
23. Leger T, Charrier A, Moreau C, Hininger-Favier I, Mourmoura E, Rigaudiere JP, Pitois E, Bouvier D, Sapin V, Pereira B, Azarnoush K and Demaison L (2017) Early sepsis does not stimulate reactive oxygen species production and does not reduce cardiac function despite an increased inflammation status. Physiol Rep 5. https://doi.org/10.14814/phy2.13231
24. Spencer NJ, Bywater RA and GS. T (1998) Evidence that myoelectric complexes in the isolated mouse. Neurosci Lett 250:153-156. https://doi.org/10.1016/s0304-3940(98)00461-3
25. Nyavor Y, Brands CR, May G, Kuther S, Nicholson J, Tiger K, Tesnohlidek A, Yasuda A, Starks K, Litvinenko D, Linden DR, Bhattarai Y, Kashyap PC, Forney LJ and Balemba OB (2020) High-fat diet-induced alterations to gut microbiota and gut-derived lipoteichoic acid contributes to the development of enteric neuropathy. Neurogastroenterol Motil 32:e13838. https://doi.org/10.1111/nmo.13838
26. Cornet A, Savidge TC, Cabarrocas J, Deng WL, Colombel JF and Lassmann H (2001) Enterocolitis induced by autoimmune targeting of enteric glial cells: a possible mechanism in Crohn's disease? Proc Natl Acad Sci U S A. 98:13306-13311. https://doi.org/10.1073/pnas.231474098
27. Rühl A, Franzke S, Collins S and Stremmel W (2001) Interleukin-6 expression and regulation in rat enteric glial cells. Am J Physiol Gastrointest Liver Physiol 280:G1163-G1171. https://doi.org/10.1152/ajpgi.2001.280.6.G1163
28. Pochard C, Coquenlorge S, Freyssinet M and Naveilhan P (2018) The multiple faces of inflammatory enteric glial cells: is Crohn's disease a gliopathy? Am J Physiol Gastrointest Liver Physiol. 315:G1-G11. https://doi.org/10.1152/ajpgi.00016.2018
29. Furness JB (2012) The enteric nervous system and neurogastroenterology. Nat Rev Gastroenterol Hepatol 9:286-94. https://doi.org/10.1038/nrgastro.2012.32
30. Long X, Li M, Li LX, Sun YY, Zhang WX, Zhao DY and Li YQ (2018) Butyrate promotes visceral hypersensitivity in an IBS-like model via enteric glial cell-derived nerve growth factor. Neurogastroenterol Motil 30:e13227. https://doi.org/10.1111/nmo.13227
31. Chow CFW, Che S, Qin HY, Kwan HY, Bian ZX and Wong HLX (2019) From psychology to physicality: how nerve growth factor transduces early life stress into gastrointestinal motility disorders later in life. Cell Cycle 18:1824-1829. https://doi.org/10.1080/15384101.2019.1637203
32. Ochoa-Cortes F, Turco F, Linan-Rico A, Soghomonyan S, Whitaker E, Wehner S, Cuomo R and Christofi FL (2016) Enteric glial cells: a new frontier in neurogastroenterology and clinical target for inflammatory bowel diseases. Inflamm Bowel Dis 22:433-49. https://doi.org/10.1097/MIB.0000000000000667
33. Zamanian JL, Xu L, Foo LC, Nouri N, Zhou L, Giffard RG and Barres BA (2012) Genomic analysis of reactive astrogliosis. J Neurosci 32:6391-410. https://doi.org/10.1523/JNEUROSCI.6221-11.2012
34. Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, Munch AE, Chung WS, Peterson TC, Wilton DK, Frouin A, Napier BA, Panicker N, Kumar M, Buckwalter MS, Rowitch DH, Dawson VL, Dawson TM, Stevens B and Barres BA (2017) Neurotoxic reactive astrocytes are induced by activated microglia. Nature 541:481-487. https://doi.org/10.1038/nature21029
35. Linan-Rico A, Turco F, Ochoa-Cortes F, Harzman A, Needleman BJ, Arsenescu R, Abdel-Rasoul M, Fadda P, Grants I, Whitaker E, Cuomo R and Christofi FL (2016) Molecular signaling and dysfunction of the human reactive enteric glial cell phenotype: implications for GI infection, IBD, POI, neurological, motility, and GI disorders. Inflamm Bowel Dis 22:1812-34. https://doi.org/10.1097/MIB.0000000000000854
36. Ruhl A (2005) Glial cells in the gut. Neurogastroenterol Motil 17:777-90. https://doi.org/10.1111/j.1365-2982.2005.00687.x
37. Clairembault T, Kamphuis W, Leclair-Visonneau L, Rolli-Derkinderen M, Coron E, Neunlist M, Hol EM and Derkinderen P (2014) Enteric GFAP expression and phosphorylation in Parkinson's disease. J Neurochem 130:805-15. https://doi.org/10.1111/jnc.12742
38. Sofroniew MV (2014) Multiple roles for astrocytes as effectors of cytokines and inflammatory mediators. Neuroscientist 20:160-72. doi: 10.1177/1073858413504466
39. Bhave S, Gade A, Kang M, Hauser KF, Dewey WL and Akbarali HI (2017) Connexin-purinergic signaling in enteric glia mediates the prolonged effect of morphine on constipation. FASEB J 31:2649-2660. https://doi.org/10.1096/fj.201601068R
40. Fonnum F, Johnsen A and Hassel B (1997) Use of fluorocitrate and fluoroacetate in the study of brain metabolism. Glia 21:106-13.
41. Furness JB (2000) Types of neurons in the enteric nervous system. J Auton Nerv Syst 81:87-96. https://doi.org/10.1016/s0165-1838(00)00127-2
42. Rao M and Gershon MD (2018) Enteric nervous system development: what could possibly go wrong? Nat Rev Neurosci 19:552-565. https://doi.org/10.1038/s41583-018-0041-0