Wire + arc additive manufacturing (WAAM) is an arc welding process that uses non-consumable tungsten electrodes to produce the weld. The material used in this study is a titanium, carbon, zirconium, and molybdenum (TZM) alloy that is physically and chemically stable and has good performance for use as a welding and high-temperature heating element. However, the price is higher than that of other materials. Because welding cannot be modified after manufacturing, economic losses are high in the case of a defective product. Therefore, it is important to find the best welding settings for the target bead geometry during welding. In this study, welding experiments are designed based on a central composite design, and single-layer WAAM is performed using a TZM material. Consequently, we obtain 17 beads and measure the height, width, as well as left and right toe angles, which represent the geometry of the beads. Based on the measured geometry, we obtain the optimal settings for the WAAM parameters whereat the mean of each geometry is close to its target value and its variance is minimized by using a desirability function method. Furthermore, we conduct additional experiments to validate the optimal settings that we obtain. We compare the predicted and actual geometry values and find that they are quite close. This result indicates that valid optimal settings for the process parameters can be obtained via the proposed method.