1 Jain, S., Kambam, S., Thanki, K. & Jain, A. K. Cyclosporine A loaded self-nanoemulsifying drug delivery system (SNEDDS): implication of a functional excipient based co-encapsulation strategy on oral bioavailability and nephrotoxicity. RSC Advances5, 49633-49642, doi:10.1039/c5ra04762e (2015).
2 Basaran, E., Demirel, M., Sirmagul, B. & Yazan, Y. Cyclosporine-A incorporated cationic solid lipid nanoparticles for ocular delivery. J Microencapsul27, 37-47, doi:10.3109/02652040902846883 (2010).
3 Liu, M., Zhong, X. & Yang, Z. Chitosan functionalized nanocochleates for enhanced oral absorption of cyclosporine A. Sci Rep7, 41322, doi:10.1038/srep41322 (2017).
4 Kesisoglou, F., Panmai, S. & Wu, Y. Nanosizing--oral formulation development and biopharmaceutical evaluation. Adv Drug Deliv Rev59, 631-644, doi:10.1016/j.addr.2007.05.003 (2007).
5 Du, B. et al. Development and characterization of glimepiride nanocrystal formulation and evaluation of its pharmacokinetic in rats. Drug Deliv20, 25-33, doi:10.3109/10717544.2012.742939 (2013).
6 Muller, R. H., Gohla, S. & Keck, C. M. State of the art of nanocrystals--special features, production, nanotoxicology aspects and intracellular delivery. Eur J Pharm Biopharm78, 1-9, doi:10.1016/j.ejpb.2011.01.007 (2011).
7 Kayaert, P. et al. Solution calorimetry as an alternative approach for dissolution testing of nanosuspensions. Eur J Pharm Biopharm76, 507-513, doi:10.1016/j.ejpb.2010.09.009 (2010).
8 Lu, Y. e. a. The in vivo fate of nanocrystals. Drug Discov Today22, 744-750, doi:10.1016/j.drudis.2017.01.003 (2017).
9 Li, Q., Liu, C. G. & Yu, Y. Separation of monodisperse alginate nanoparticles and effect of particle size on transport of vitamin E. Carbohydr Polym124, 274-279, doi:10.1016/j.carbpol.2015.02.007 (2015).
10 He, Y., Xia, Dn., Li, Qx. et al. Enhancement of cellular uptake, transport and oral absorption of protease inhibitor saquinavir by nanocrystal formulation. Acta Pharmacol Sin36, 1151-1160, doi:10.1038/aps.2015.53 (2015).
11 Xie, Y. et al. Epithelia transmembrane transport of orally administered ultrafine drug particles evidenced by environment sensitive fluorophores in cellular and animal studies. J Control Release270, 65-75, doi:10.1016/j.jconrel.2017.11.046 (2018).
12 Wang, R., Wang, X., Jia, X., Wang, H. & Li, J. Impacts of particle size on the cytotoxicity, cellular internalization, pharmacokinetics and biodistribution of betulinic acid nanosuspensions in combined chemotherapy. International Journal of Pharmaceutics588, 119799 (2020).
13 Langston Suen, W. L. & Chau, Y. Size-dependent internalisation of folate-decorated nanoparticles via the pathways of clathrin and caveolae-mediated endocytosis in ARPE-19 cells. J Pharm Pharmacol66, 564-573, doi:10.1111/jphp.12134 (2014).
14 Rejman, J., Oberle, Zuhorn, I. & Hoekstra, D. Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochemical Journal377, 159-169 (2004).
15 Bi, C. et al. Particle size effect of curcumin nanosuspensions on cytotoxicity, cellular internalization, in vivo pharmacokinetics and biodistribution. Nanomedicine13, 943-953, doi:10.1016/j.nano.2016.11.004 (2017).
16 Zhang, X. et al. Exploration of nanocrystal technology for the preparation of lovastatin immediate and sustained release tablets. Journal of Drug Delivery Science and Technology50, 107-112, doi:10.1016/j.jddst.2019.01.018 (2019).
17 Zhang, X., Li, L. C. & Mao, S. Nanosuspensions of poorly water soluble drugs prepared by top-down technologies. Curr Pharm Des20, 388-407, doi:10.2174/13816128113199990401 (2014).
18 Jacob, S., Nair, A. B. & Shah, J. Emerging role of nanosuspensions in drug delivery systems. Biomater Res24, 3, doi:10.1186/s40824-020-0184-8 (2020).
19 Pawar, V. K., Singh, Y., Meher, J. G., Gupta, S. & Chourasia, M. K. Engineered nanocrystal technology: in-vivo fate, targeting and applications in drug delivery. J Control Release183, 51-66, doi:10.1016/j.jconrel.2014.03.030 (2014).
20 Romero, G. B., Arntjen, A., Keck, C. M. & Muller, R. H. Amorphous cyclosporin A nanoparticles for enhanced dermal bioavailability. Int J Pharm498, 217-224, doi:10.1016/j.ijpharm.2015.12.019 (2016).
21 Ding, W. et al. Co-delivery of honokiol, a constituent of Magnolia species, in a self-microemulsifying drug delivery system for improved oral transport of lipophilic sirolimus. Drug Delivery, 1-11 (2016).
22 Cummins, C. L., Salphati, L., Reid, M. J. & Benet, L. Z. In Vivo Modulation of Intestinal CYP3A Metabolism by P-Glycoprotein: Studies Using the Rat Single-Pass Intestinal Perfusion Model. Journal of Pharmacology and Experimental Therapeutics305, 306-314 (2003).
23 Rahman, Z. et al. Characterization of 5-fluorouracil microspheres for colonic delivery. AAPS PharmSciTech7, E47, doi:10.1208/pt070247 (2006).
24 Guada, M., Lasa-Saracibar, B., Lana, H., Dios-Vieitez Mdel, C. & Blanco-Prieto, M. J. Lipid nanoparticles enhance the absorption of cyclosporine A through the gastrointestinal barrier: In vitro and in vivo studies. Int J Pharm500, 154-161, doi:10.1016/j.ijpharm.2016.01.037 (2016).
25 Mu, L. & Feng, S. S. Vitamin E TPGS used as emulsifier in the solvent evaporation/extraction technique for fabrication of polymeric nanospheres for controlled release of paclitaxel (Taxol). Journal of Controlled Release80, 129-144 (2002).
26 Jog, R. & Burgess, D. J. Comprehensive Quality by Design Approach for Stable Nanocrystalline Drug Products. International Journal of Pharmaceutics (2019).
27 Gratton, S. E. et al. The effect of particle design on cellular internalization pathways. Proc Natl Acad Sci U S A105, 11613-11618, doi:10.1073/pnas.0801763105 (2008).
28 Jani, P., Halbert, G. W., Langridge, J. & Florence, A. T. Nanoparticle Uptake by the Rat Gastrointestinal Mucosa: Quantitation and Particle Size Dependency. Journal of Pharmacy and Pharmacology42 (1990).
29 Kulkarni, S. A. & Feng, S. S. Effects of Particle Size and Surface Modification on Cellular Uptake and Biodistribution of Polymeric Nanoparticles for Drug Delivery. Pharmaceutical Research30, 2512 (2013).
30 Olejnik M, K. M., Rosenkranz N. et al. Cell-biological effects of zinc oxide spheres and rods from the nano- to the microscale at sub-toxic levels. Cell Biology and Toxicology (2020).
31 Salatin, S., Dizaj, S. M. & Khosroushahi, A. Y. Effect of the surface modification, size, and shape on cellular uptake of nanoparticles. Cell Biology International39 (2015).
32 Fricker, G., Drewe, J., Huwyler, J., Gutmann, H. & Beglinger, C. Relevance of p-glycoprotein for the enteral absorption of cyclosporin A: in vitro-in vivo correlation. British Journal of Pharmacology118, 1841-1847 (2012).
33 Rennick, J. J., Johnston, A. P. R. & Parton, R. G. Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics. Nat Nanotechnol16, 266-276, doi:10.1038/s41565-021-00858-8 (2021).
34 Jenkins, P. G. e. a. Microparticulate absorption from the rat intestine. Journal of Controlled Release29, 339-350 (1994).
35 Witoonsaridsilp, W., Panyarachun, B., Jaturanpinyo, M. & Sarisuta, N. Phospholipid vesicle–bound lysozyme to enhance permeability in human intestinal cells. Pharmaceutical Development & Technology18, 821-827 (2013).
36 Chithrani, B. D. & Chan, W. C. Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes. Nano Lett7, 1542-1550, doi:10.1021/nl070363y (2007).
37 Kristin Denzer, M. J. K., Harry F. G. Heijnen, Willem Stoorvogel and Hans J. Geuze. <Exosome from internal vesicle of the multivesicular body to intercellular signaling device.pdf>. Journal of Cell Science113, 3365-3374 (2000).
38 Chen, T. et al. Oral Delivery of a Nanocrystal Formulation of Schisantherin A with Improved Bioavailability and Brain Delivery for the Treatment of Parkinson's Disease. Molecular Pharmaceutics, acs.molpharmaceut.6b00644 (2016).
39 Stappaerts, J., Brouwers, J., Annaert, P. & Augustijns, P. In situ perfusion in rodents to explore intestinal drug absorption: Challenges and opportunities. International Journal of Pharmaceutics478, 665-681 (2015).
40 Chen, G., Min, X., Zhang, Q., Zhang, Z. & Cheng, G. Synthesis and Evaluation of PEG-PR for Water Flux Correction in an In Situ Rat Perfusion Model. Molecules25, 5123 (2020).
41 Hussain, N., Jaitley, V. & Florence, A. T. Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics. Advanced Drug Delivery Reviews50, 107-142 (2001).
42 Fojo, A. T. et al. Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci U S A84, 265-269, doi:10.1073/pnas.84.1.265 (1987).
43 Cao, X. et al. Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model. Pharm Res23, 1675-1686, doi:10.1007/s11095-006-9041-2 (2006).
44 des Rieux, A., Fievez, V., Garinot, M., Schneider, Y. J. & Préat, V. Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach. J Control Release116, 1-27, doi:10.1016/j.jconrel.2006.08.013 (2006).
45 Gao, L. et al. Drug nanocrystals: In vivo performances. J Control Release160, 418-430, doi:10.1016/j.jconrel.2012.03.013 (2012).