Obesity and overweight pose serious risk for many diseases and clinical conditions.
However currently available weight loss strategies and pharmacotherapies of obesity are not
satisfactory. This study shows that treatments with pH modifiers such as acids are not only well
tolerated by obese mice but also very effective in reducing bodyweight and fat mass by depleting
and suppressing the proliferation of proliferating epithelial cells of the intestinal villi. Therefore
other cell proliferation inhibitors that suppress intestinal epithelial renewal can also be used for
pharmacotherapy of obesity and overweight.