This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
songjing shi
FujianProvincialHospital
Corresponding Author
License:
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OBJECTIVE
Pulmonary embolism is a terrible cardiovascular condition with considerable morbidity and mortality.Previous studies have investigated that systolic blood pressure(Systolic BP)and diastolic blood pressure(Diastolic BP) were related to 30-day and in-hospital mortality.We aimed to determine if the average mean arterial pressure(aMAP) in the first 24 hours of hospital admission is useful to predict short-term outcomes of intermediate-risk and high-risk PE patients.
Method
We conducted a single center retrospective study.From May 2012 and April 2019, 122 intermediate-risk and high-risk PE patients were included.The primary outcome was in-hospital mortality.The secondary outcome was adverse events.ROC curves and cut-off values for aMAP predicting in-hospital-death were computed.According to cut-off values,we categorize five groups defined as followed:group 1:aMAP<70mmHg;group2:70mmHg≤aMAP<80mmHg;group3:80mmHg≤aMAP<90mmHg;group4:90mmHg≤aMAP<100mmHg;group5:aMAP≥100mmHg.Cox regression models were calculated to investigate associations between aMAP and in-hospital-death.
Result
In the study group of 122 patients,15 patients (12.30%) died in hospital due to PE.ROC analysis for MAP predicting in-hospital-death revealed an AUC of 0.729 with cut-off value of 79.4mmHg.Cox regression models showed a significant association between in-hospital death and aMAP group1(Ref),aMAP group2(OR1.680,95CI%0.020-140.335),aMAPgroup3(OR0.003,95CI%0.0001-0.343),aMAPgroup4(OR0.006,95CI%0.0001-1.671),aMAPgroup5(OR0.003,95%CI0.0001-9.744. It is aMAP 80-90mmHg that suffer from minimum adverse events
Conclusion
Prognostic role of MAP at the first 24 hours of hospital admission should be emphasized in patients with PE.80 to 90mmHg may be the optimal range of MAP for intermediate-risk and high-risk PE patients.
Keywords
pulmonary embolism, intermediate-risk, high-risk, mean arterial pressure, mortality, adverse events
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
songjing shi
FujianProvincialHospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 02 Jan, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Critical Care & Emergency Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
OBJECTIVE
Pulmonary embolism is a terrible cardiovascular condition with considerable morbidity and mortality.Previous studies have investigated that systolic blood pressure(Systolic BP)and diastolic blood pressure(Diastolic BP) were related to 30-day and in-hospital mortality.We aimed to determine if the average mean arterial pressure(aMAP) in the first 24 hours of hospital admission is useful to predict short-term outcomes of intermediate-risk and high-risk PE patients.
Method
We conducted a single center retrospective study.From May 2012 and April 2019, 122 intermediate-risk and high-risk PE patients were included.The primary outcome was in-hospital mortality.The secondary outcome was adverse events.ROC curves and cut-off values for aMAP predicting in-hospital-death were computed.According to cut-off values,we categorize five groups defined as followed:group 1:aMAP<70mmHg;group2:70mmHg≤aMAP<80mmHg;group3:80mmHg≤aMAP<90mmHg;group4:90mmHg≤aMAP<100mmHg;group5:aMAP≥100mmHg.Cox regression models were calculated to investigate associations between aMAP and in-hospital-death.
Result
In the study group of 122 patients,15 patients (12.30%) died in hospital due to PE.ROC analysis for MAP predicting in-hospital-death revealed an AUC of 0.729 with cut-off value of 79.4mmHg.Cox regression models showed a significant association between in-hospital death and aMAP group1(Ref),aMAP group2(OR1.680,95CI%0.020-140.335),aMAPgroup3(OR0.003,95CI%0.0001-0.343),aMAPgroup4(OR0.006,95CI%0.0001-1.671),aMAPgroup5(OR0.003,95%CI0.0001-9.744. It is aMAP 80-90mmHg that suffer from minimum adverse events
Conclusion
Prognostic role of MAP at the first 24 hours of hospital admission should be emphasized in patients with PE.80 to 90mmHg may be the optimal range of MAP for intermediate-risk and high-risk PE patients.
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
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