The global minimum point of an optimization problem is of interest in engineering fields and it is difficult to be solved, especially for a nonconvex large-scale optimization problem. In this article, we consider the continuation Newton method with the deflation technique and the quasi-genetic evolution for this problem. Firstly, we use the continuation Newton method with the deflation technique to find the stationary points from several determined initial points as many as possible. Then, we use those found stationary points as the initial evolutionary seeds of the quasi-genetic algorithm. After it evolves into several generations, we obtain a suboptimal point of the optimization problem. Finally, we use the continuation Newton method with this suboptimal point as the initial point to obtain the stationary point, and output the minimizer between this final stationary point and the found suboptimal point of the quasi-genetic algorithm. Finally, we compare it with the multi-start method (the built-in subroutine GlobalSearch.m of the MATLAB R2020a environment) and the differential evolution algorithm (the DE method, the subroutine de.m of the MATLAB Central File Exchange 2021), respectively. Numerical results show that the proposed method performs well for the large-scale global optimization problems, especially the problems of which are difficult to be solved by the known global optimization methods.