The non-planar hex-rotor aircraft mentioned in this article can change its flight status by simply changing the tilt angle of the rotor. In this paper, mainly studied the best aerodynamic performance of a non-planar hex-rotor aircraft under the influence of horizontal wind (0m/s, 2.5m/s and 4m/s). Firstly, the rotation speed of the rotor is a fixed value (2200r/min) in the low-speed wind tunnel test, the horizontal wind speed and the tilt angle of the rotor are variable values, the thrust, power consumption and power loading(PL) values of the aircraft are obtained. Secondly, the computational fluid dynamics(CFD) method is used to simulate the aerodynamic performance of a non-planar hex-rotors aircraft when subjected to a horizontal wind to obtain the simulation results. Finally, comparing the experimental values and the simulation values, it is found that the horizontal speed has a greater impact on the thrust and power consumption of the non-planar hex-rotor aircraft. From the change of PL values, it is concluded that the horizontal wind speed is 0m/s, 2.5m/s, 4m/s, the best inclination angle is 10°, 30°and 50°, and the strongest anti-wind performance.