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Research article
Shifting Demographics and Comorbidity Burden in Chinese Urban Patients With Chronic Hepatitis B, 2013 and 2016
Ling-I Hsu
Corresponding Author
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Background: The long-term safety of anti-hepatitis B virus (HBV) therapies is critical to assess, particularly in the context of aging chronic hepatitis B (CHB) populations and accumulating comorbidities. HBV is common and clinically consequential in China; however, the demographics and comorbidity burden of this population have not been fully characterized.
Aim: To characterize changes in demographics and comorbidity burden of urban Chinese patients with CHB between 2013 and 2016.
Methods: The China Health Insurance Research Association (CHIRA) annual urban health insurance claims database from 2013 and 2016 was used to identify adults with ≥1 ICD-10 code for CHB. Descriptive analyses were conducted to compare age and comorbidities distributions between 2013 and 2016.
Results: Median age increased from 40 in 2013 (N=14,545) to 44 in 2016 (N=11,648) (P<0.001). The proportion of patients aged >45 years increased significantly from 40.3% in 2013 to 49% in 2016 (P<0.001). Significant increases in multiple comorbidities were observed, including hypertension (9.4% to 14.5%), hyperlipidemia (4.7% to 7.0%), and cardiovascular disease (5.7% to 10%) (P<0.001 for all comparisons). Increases were also observed in renal impairment (8.8% to 10.0%; P<0.001) and osteoporosis and/or pathologic nontraumatic bone fracture (3.8% to 7.3%; P<0.001).
Conclusions: Even over the short interval assessed in this study, there was a significant shift in the characteristics of urban CHB patients in China. Aging of the population was accompanied by significant increases in the percentage of patients having potentially concerning comorbidities. Careful selection of treatment options and comorbidity monitoring should be considered when managing Chinese patients with CHB.
Keywords
chronic hepatitis B, age, comorbidity, renal impairment, osteoporosis
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This is a preprint. It has not completed peer review.
Research article
Shifting Demographics and Comorbidity Burden in Chinese Urban Patients With Chronic Hepatitis B, 2013 and 2016
Ling-I Hsu
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 09 Jan, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Gastroenterology & Hepatology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The long-term safety of anti-hepatitis B virus (HBV) therapies is critical to assess, particularly in the context of aging chronic hepatitis B (CHB) populations and accumulating comorbidities. HBV is common and clinically consequential in China; however, the demographics and comorbidity burden of this population have not been fully characterized.
Aim: To characterize changes in demographics and comorbidity burden of urban Chinese patients with CHB between 2013 and 2016.
Methods: The China Health Insurance Research Association (CHIRA) annual urban health insurance claims database from 2013 and 2016 was used to identify adults with ≥1 ICD-10 code for CHB. Descriptive analyses were conducted to compare age and comorbidities distributions between 2013 and 2016.
Results: Median age increased from 40 in 2013 (N=14,545) to 44 in 2016 (N=11,648) (P<0.001). The proportion of patients aged >45 years increased significantly from 40.3% in 2013 to 49% in 2016 (P<0.001). Significant increases in multiple comorbidities were observed, including hypertension (9.4% to 14.5%), hyperlipidemia (4.7% to 7.0%), and cardiovascular disease (5.7% to 10%) (P<0.001 for all comparisons). Increases were also observed in renal impairment (8.8% to 10.0%; P<0.001) and osteoporosis and/or pathologic nontraumatic bone fracture (3.8% to 7.3%; P<0.001).
Conclusions: Even over the short interval assessed in this study, there was a significant shift in the characteristics of urban CHB patients in China. Aging of the population was accompanied by significant increases in the percentage of patients having potentially concerning comorbidities. Careful selection of treatment options and comorbidity monitoring should be considered when managing Chinese patients with CHB.
Figure 1
Figure 2
Figure 3