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Ireland
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United Kingdom
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MAMI trial (10)
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MOON trial (13)
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CINNAMON trial (14)
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Strategy 1: Newsletters (posted)
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€1990
(£1711.40)
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€1590.58
(£1367.90)
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€887.52
(£763.27)
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€734.51
(£631.68)
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€1874.05
(£1611.63)
($2220.96)
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Assumptions
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2 newsletters per year; 500 participants; 1-year trial period.
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2 newsletters per year; 500 participants; 1-year trial period.
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2 newsletters per year; 60 participants; 2-year trial period1.
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2 newsletters per year; 154 participants; 1-year trial period.
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2 newsletters per year; 428 participants; 2-year trial period.
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Effect estimate2
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“The evidence is very uncertain about the effect on retention of including a newsletter compared to no newsletter: RD = -0% (95% CI ‐4–3%); GRADE: very low”
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Cost per participant retained
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Current evidence suggestions no retention benefit, unable to calculate cost per participant retained due to lack of evidence
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Ireland
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United Kingdom
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MAMI trial
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MOON trial
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CINNAMON trial
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Strategy 1: Newsletters (emailed)
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€741.78
(£637.93)
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€572.36
(£492.23)
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€911.72
(£784.08)
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€525.93
(£452.30)
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€1036.39
(£891.27)
($1228.24)
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Assumptions
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2 newsletters electronically sent per year; 500 participants; 1 year trial period
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2 newsletters electronically sent per year; 500 participants; 1 year trial period
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2 newsletters electronically sent per year; 60 participants; 2-year trial period
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2 newsletters electronically sent per year; 154 participants; 1 year trial period
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2 newsletters electronically sent per year; 428 participants; 2-year trial period
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Effect estimate
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“The evidence is very uncertain about the effect on retention of including a newsletter compared to no newsletter: RD = -0% (95% CI ‐4–3%); GRADE: very low”
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Cost per participant retained
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Current evidence suggestions no retention benefit, unable to calculate cost per participant retained due to lack of evidence
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Ireland
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United Kingdom
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MAMI trial
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MOON trial
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CINNAMON trial
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Strategy 2: A timeline of participant visits for sites (site reminder)
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€791.75
(£608.91)
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€1119.50
(£962.77)
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€101.34
(£87.15)
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€111.95
(£96.28)
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€561.19
(£482.61)
($665.07)
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Assumptions
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Data Manager develops reminder schedule, electronically emails the software to the sites (10 sites)
Carried out once
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Data Manager develops reminder schedule, electronically emails the software to the sites (10 sites)
Carried out once
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Data Manager develops reminder schedule, electronically emails the software to the sites (1 site)
Carried out once
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Data Manager develops reminder schedule, electronically emails the software to the sites (1 site)
Carried out once
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Data Manager develops reminder schedule, electronically emails the software to the sites (5 sites)
Carried out once
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Effect estimate
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No evidence provided in the systematic review
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Cost per participant retained
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Unable to calculate cost per participant retained due to lack of evidence
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A timeline of participant visits for sites (participant reminder)
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€68021.75
(£58498.77)
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€5361.36
(£4610.77)
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€2945.34
(£2533.00)
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€1418.44
(£1219.86)
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€108471.99
(£93282.99)
($128551.47)
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Assumptions
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Research nurse contacts each participant prior to visit and conducts preparation prior to each visit; 500 participants; 3 visits. Includes cost of site reminder schedule.
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Trial manager contacts each participant prior to visit; 500 participants; 3 visits. Includes cost of site reminder schedule.
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Research nurse contacts each participant prior to visit and conducts preparation prior to outpatient visit and birth; 60 participants; 1 visit but preparation work for 2 visits. Includes cost of site reminder schedule.
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Trial manager contacts each participant prior to visit; 154 participants; 3 trial visits. Includes cost of site reminder schedule.
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Research nurse contacts each participant prior to visit and conducts preparation prior to each visit; 428 participants; 9 visits. Includes cost of site reminder schedule.
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Effect estimate
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No evidence provided in the systematic review
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Cost per participant retained
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Unable to calculate cost per participant retained due to lack of evidence
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Ireland
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United Kingdom
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MAMI trial
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MOON trial
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CINNAMON trial
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Strategy 3: Inclusion of pre-paid envelopes (questionnaire)
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€942.50
(£810.55)
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€804.12
(£691.54)
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€93.44
(£80.36)
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€497.31
(£427.69)
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€390.10
(£335.47)
($462.31)
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Assumptions
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1 questionnaire to all 500 participants; 1 reminder to 30% of participants (150); overall retention
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1 questionnaire to all 500 participants; 1 reminder to 30% of participants (150); overall retention
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1 questionnaire to all 60 participants; 1 reminder to 30% of participants (18); overall retention
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2 questionnaires to all 154 participants; 1 reminder for each questionnaire to 30% of participants (47); overall retention
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1 questionnaire to all 428 participants; 1 reminder to 30% of participants (129); overall retention
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Effect estimate
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“Various strategies compared to usual practice for return postage, such as free post versus second class stamp; high priority mail stamp versus usual postage; and personal form may increase retention slightly: RD = 4% (95% CI -0–9%); GRADE: low” 3
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Additional participants retained
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20
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20
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2
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12
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17
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Cost per participant retained
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€47.13
(£40.53)
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€40.21
(£34.58)
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€46.72
(£40.18)
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€41.44
(£35.64)
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€22.94
(£19.73)
($27.19)
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Strategy 4: Telephone reminders
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Ireland
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United Kingdom
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MAMI trial
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MOON trial
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CINNAMON trial
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Telephone reminders for trial visits
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€9153
(£7871.59)
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€5991.62
(£5152.80)
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€203.40
(£174.92)
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€1845.42
(£1587.06)
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€14691.47
(£12634.27)
($17411.04)
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Assumptions
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Research nurse contacts 500 participants– 5 minutes per call-carried out once for each visit (3-visits)
Failed contact attempts – research nurse contacts 500 participants - 2 failed contact attempts (1 minute each) – carried out for each visit (3 visits)
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Trial Manager contacts 500 participants– 5 minutes per call-carried out once for each visit (3-visits)
Failed contact attempts – trial manager contacts 500 participants - 2 failed contact attempts (1 minute each) – carried out for each visit (3 visits)
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Research nurse contacts 60 participants– 5 minutes per call-carried out once (1 trial visit)
Failed contact attempts – research nurse contacts 60 participants - 2 failed contact attempts (1 minute each) – carried out once (1 trial visit)
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Trial Manager contacts 154 participants– 5 minutes per call-carried out once for each visit (3-visits)
Failed contact attempts – trial manager contacts 154 participants - 2 failed contact attempts (1 minute each) – carried out for each visit (3 visits)
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Research nurse contacts 428 participants– 5 minutes per call-carried out once for each visit (9 trial visits)
Failed contact attempts – research nurse contacts 428 participants - 2 failed contact attempts (1 minute each) – carried out once for each visit (9 trial visit)
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Effect estimate
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“Telephone reminders compared to usual follow-up may result in little or no difference to retention (smoking cessation (12)): RD = ‐1% (95% CI ‐18–15%); GRADE low (‐2 levels: imprecision‐single study, n = 127; wide CI crossing RD = 0)” 4
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Cost per participant retained
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With a risk difference of negative 1 there are no participants retained with this strategy so cost per participant retained cannot be calculated
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Telephone reminders for questionnaire response
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€423.75
(£364.43)
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€568.62
(£489.01)
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€34.58
(£29.74)
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€356.33
(£306.44)
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€246.00
(£211.56)
($291.54)
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Assumptions
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Research assistant contacts 30% of participants (150) – 5 minutes per call – carried out once
Failed contact attempts – research assistant contacts 150 participants– 2 failed attempts - 1 minute per attempt –carried out once
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Research assistant contacts 30% of participants (150) – 5 minutes per call – carried out once
Failed contact attempts – research assistant contacts 150 participants– 2 failed attempts - 1 minute per attempt –carried out once
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Research assistant contacts 30% of participants (18) – 5 minutes per call – carried out once
Failed contact attempts – research assistant contacts 18 participants– 2 failed attempts - 1 minute per attempt –carried out once
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Research assistant contacts 30% of participants (47)– 5 minutes per call – carried out twice
Failed contact attempts – research assistant contacts 47 participants– 2 failed attempts - 1 minute per attempt –carried out twice
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Research assistant contacts 30% of participants (129) – 5 minutes per call – carried out once
Failed contact attempts – research assistant contacts 129 participants– 2 failed attempts - 1 minute per attempt –carried out once
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Effect estimate
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“Telephone reminders compared to usual follow-up may result in little or no difference to retention (smoking cessation(12)): RD = ‐1% (95% CI ‐18–15%); GRADE low (‐2 levels: imprecision‐single study, n = 127; wide CI crossing RD = 0)”
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Cost per participant retained
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With a risk difference of negative 1 there are no participants retained with this strategy so cost per participant retained cannot be calculated
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Telephone reminders for at home data collection
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|
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€244.08
(£209.91)
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|
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Assumptions
|
|
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Research nurse contacts 30% of participants (18) – 5 minutes per call - 1 reminder for each at home data collection (4 in total)
|
|
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Effect estimate
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“Telephone reminders compared to usual follow-up may result in little or no difference to retention (smoking cessation (12)): RD = ‐1% (95% CI ‐18–15%); GRADE low (‐2 levels: imprecision‐single study, n = 127; wide CI crossing RD = 0)”
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Cost per participant retained
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With a risk difference of negative 1 there are no participants retained with this strategy so cost per participant retained cannot be calculated
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Ireland
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United Kingdom
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MAMI trial
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MOON trial
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CINNAMON trial
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Strategy 5: Data collection scheduled with routine care
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€20250
(£17415.02)
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€15697.67
(£13500)
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€900
(£774.00)
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€4834.88
(£4158)
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€32503.25
(£27951.92)
($38520)
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Assumptions
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Carried out by a research nurse during a routine care visit – 15 minutes – carried out 3 times for each participant (once for each trial visit)
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Carried out by a research nurse during a routine care visit – 15 minutes – carried out 3 times for each participant (once for each trial visit)
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Carried out by a research nurse during a routine care visit – 15 minutes – carried out twice for each participant (outpatient clinic data collection and data collection at birth)
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Carried out by a research nurse during a routine care visit – 15 minutes – carried out 3 times for each participant (3 trial visits)
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Carried out by a research nurse during a routine care visit – 15 minutes – carried out 9 times for each participant (9 trial visits)
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Effect estimate
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No evidence provided in the systematic review
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Cost per participant retained
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Unable to calculate cost per participant retained due to lack of evidence
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Ireland
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United Kingdom
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MAMI trial
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MOON trial
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CINNAMON trial
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Strategy 6: Site initiation training on missing data
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€7000
(£6020.00)
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€7376.74
(£6344)
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€400
(£344.00)
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€388.83
(£334.40)
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€2953.31
(£2539.76)
($3500)
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Assumptions
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Prep, site training and report per site @€400 per day plus travel and overnight costs.
Carried out once for each site (10 sites)
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Prep, site training and report by Trial manager (11 hours of work) – plus travel and overnight costs. Carried out once per site (10 sites)
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Prep, site training and report per site @€400 per day.
Carried out once (1 site)
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Prep, site training and report by Trial Manager (11 hours of work) Carried out once (1 site)
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Prep, site training and report per site @€400 per day plus travel and overnight costs.
Carried out once for each site (5 sites)
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Effect estimate
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No evidence provided in the systematic review
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Cost per participant retained
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Unable to calculate cost per participant retained due to lack of evidence
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|
Ireland
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United Kingdom
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MAMI trial
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MOON trial
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CINNAMON trial
|
Strategy 7: Investigator meetings face to face
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€14000
(£12040.01)
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€14753.48
(£12688)
|
€1600
(£1376)
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€777.67
(£668.80)
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€11813.22
(£10159.06)
($14000)
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Assumptions
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Prep, meeting, and report per site @€400 per day plus travel and overnight costs.
Carried out twice per site over 1 year trial period (10 sites)
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Prep, meeting, and report by Trial manager (11 hours of work) – plus travel and overnight costs. Carried out twice per site over 1 year trial period (10 sites)
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Prep, meeting, and report per site @€400 per day
Carried out 4 times for each site over 2-year trial period (1 site)
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Prep, meeting, and report by Trial manager (11 hours of work). Carried out twice per site over 1 year trial period (1 site)
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Prep, meeting, and report per site @€400 per day plus travel and overnight costs.
Carried out 4 times for each site over 2-year trial period (5 sites)
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Effect estimate
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No evidence provided in the systematic review
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Cost per participant retained
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Unable to calculate cost per participant retained due to lack of evidence
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|
Ireland
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United Kingdom
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MAMI trial
|
MOON trial
|
CINNAMON trial
|
Strategy 8: Routine site visits by CTU staff
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€14000
(£12040.01)
|
€14753.48
(£12688)
|
€1600
(£1376)
|
€777.67
(£668.80)
|
€11813.22
(£10159.06)
($14000)
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Assumptions
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Prep, site visit and report per site @€400 per day plus travel and overnight costs.
Carried out twice per site over 1 year trial period (10 sites)
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Prep, site visit and report by Trial manager (11 hours of work) – plus travel and overnight costs. Carried out twice per site over 1 year trial period (10 sites)
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Prep, site visit and report per site @€400 per day
Carried out 4 times per site over 2-year trial period (1 site)
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Prep, site visit and report by Trial manager (11 hours of work). Carried out twice per site over 1 year trial period (1 site)
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Prep, site visit and report per site @€400 per day plus travel and overnight costs
Carried out 4 times per site over 2-year trial period (5 sites)
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Effect estimate*
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No evidence provided in the systematic review
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Cost per participant retained
|
Unable to calculate cost per participant retained due to lack of evidence
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|
Ireland
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United Kingdom
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MAMI trial
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MOON trial
|
CINNAMON trial
|
Strategy 9: Targeted recruitment of sites/GPs
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€1620
(£1393.20)
|
€1060.46
(£912)
|
€30
(£25.80)
|
€35.35
(£30.40)
|
€506.28
(£435.39)
($600)
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Assumptions
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Research nurse carries out site selection and investigation (1 hour work per site) – 30 sites are targeted
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Trial manager carries out site selection and investigation (1 hour work per site) – 30 sites are targeted
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Research nurse carries out site selection and investigation (1 hour work per site) –single centre so only 1 site targeted
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Trial manager carries out site selection and investigation (1 hour work per site) – single centre so only 1 site targeted
|
Research nurse carries out site selection and investigation (1 hour work per site) – 15 sites are targeted
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Effect estimate
|
No evidence provided in the systematic review
|
Cost per participant retained
|
Unable to calculate cost per participant retained due to lack of evidence
|
|
Ireland
|
United Kingdom
|
MAMI trial
|
MOON trial
|
CINNAMON trial
|
Strategy 10: Flexibility in appointments
|
€4050
(£3483.00)
|
€3139.53
(£2700)
|
€270
(£232.20)
|
€1004.65
(£864)
|
€2177.01
(£1872.17)
($2580)
|
Assumptions
|
Research nurse carries out out-of-hours visits for 10% of participants (50) – 1.5-hour visit
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Research nurse carries out out-of-hours visits for 10% of participants (50) – 1.5-hour visit
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Research nurse carries out out-of-hours visits for 10% of participants (6) – 1.5-hour visit
|
Research nurse carries out out-of-hours visits for 10% of participants (16) – 1.5-hour visit
|
Research nurse carries out out-of-hours visits for 10% of participants (47) – 1.5-hour visit
|
Effect estimate
|
No evidence provided in the systematic review
|
Cost per participant retained
|
Unable to calculate cost per participant retained due to lack of evidence
|