TR is currently a National Institute of Health Research (NIHR) Clinical Lecturer (CL-2017-11-02) and was previously funded by a NIHR Doctoral Research Fellowship (DRF-2014-07-079). AT is funded by a Sir Henry Wellcome Fellowship. SP is an NIHR Clinician Scientist (CS-2016-16-019). This work was undertaken with the support of the NIHR Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health and Social Care.
The other authors have no competing interests to declare.
Data availability statement
The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
SP and TR conceived the study design (subgroup analysis); TR contributed to the design, conduct, analysis of the data, interpretation of the results and wrote the first draft of the paper. AT performed the analysis, contributed to data interpretation, and drafted the manuscript. RLOC, TR, RVD, SP contributed to the study design for iBRA-2; MDG and JS contributed to study design and interpretation of the data. All authors read and approved the final manuscript.
Members of the iBRA-2 steering group are (in alphabetical order) Nicola LP Barnes, Jane Blazeby, Elizabeth Conroy, Rajiv V Dave, Matthew D Gardiner, Adrian Harnett, Chris Holcombe, Ciara O’Brien, Rachel O’Connell, Shelley Potter, Tim Rattay, and Joanna Skillman.
Local iBRA-2 investigators (alphabetically by centre) and members of the Breast Reconstruction Research Collaborative are PUBMED citable collaborators in this study and were: Aberdeen Royal Infirmary, NHS Grampian; Alain Curnier, Amir Tadros, Ivan Depasquale, Yazan A Masannat Elizabeth Smyth, Mairi Fuller, Roger Bourne, Steven Heys, Ishrak Hamo. Addenbrookes Hospital, Cambridge Universities NHS Foundation Trust; Fatima Aloraifi, Laura Fopp, Radhika Bali, Sarah Bache, Sarah L Benyon, Michael S Irwin, Amit Agrawal, Charles M Malata. Airedale NHS Foundation Trust; Claire Murphy. Basildon and Thurrock Hospitals NHS Foundation Trust; Adam Misky, Dennis Wayne Chicken. Beaumont Hospital and the RCSI; Nassreen Abdullah, Arnold D K Hill. Belfast City Hospital, Belfast Health and Social Care Trust; Carolyn Cullinane, Gareth Irwin, Stuart A McIntosh, Sigi Refsum, Samantha Sloan, Peter Mallon. Betsi Cadwaladr University Health Board; Chiara Sirianni, Ilyas Khattak, Chiara Sirianni. Blackpool Teaching Hospitals NHS Foundation Trust; Geerthan Nagachandra, Pasupathy Kiruparan, Debasish Debanth. Breast Care Centre, North Bristol NHS Trust, Southmead Hospital, Bristol; Simon Davey, Terry-Ann Curran, Matilda Svenning, Sasirekha Govindarajulu, Zenon Rayter, Rachel Ainsworth, Simon Cawthorn, Ajay Sahu, Sherif Wilson, Elena Prousskaia. Breast Unit Department. University of Naples “Federico II”, Naples, Italy; Antonello Accurso, Nicola Rocco, Rosa Di Micco, Antonello Accurso, Gennaro Limite. Breast Unit Department S. Maria delle Grazie ASL Na 2 Pozzuoli; Raffaele Ceccarino, Raffaele Liccardo, Guido Coco. Broomfield Hospital, Mid Essex Hospital Services NHS Trust; Metin Nizamoglu, Mary Morgan, Venkat Ramakrishnan. Cannizzaro Hospital, Catania; Giuseppe Catanuto. Castle Hill Hospital, Hull and East Yorkshire Hospitals NHS Trust; Alex Wilkins, Penelope McManus, Peter Kneeshaw, Kartikae Grover, Tapan Mahapatra, Brendan Wooler, Bilal Elahi, Naila Ihsan. Charing Cross Hospital, Imperial College Healthcare NHS Trust; Alexandra Bucknor, Dimitris Reissis, Judith Hunter, Simon Wood, Navid Jallali, Francis P Henry, Liaquat S Verjee, Jason Lee. Chesterfield Royal Hospital NHS Foundation Trust; Shazia M Khan, Iman Azmy, Julia Massey, Ciaran Hollywood, Michael Oluwajana. Countess of Chester Hospital NHS Foundation Trust; Sonia Bathla, Joanna Seward, Claudia Harding-MacKean. Darent Valley Hospital, Dartford and Gravesham NHS Trust; Risha Lane, Kothandaraman Murali, Bashishta Biswas, Pawel Trapszo, Seema Seetharam. Dorset County Hospital NHS Foundation Trust; Katy Kennedy, Louise Alder, Tomasz Graja. East Cheshire NHS Trust; Khalid Amin, Jalal Kokan, Chandeena Roshanlall. Edinburgh Breast Unit, Western General Hospital, NHS Lothian; Emma Gill, Dhananjay Kulkarni, JM Dixon, Oliver Young, Talha Saleem. Glasgow Royal Infirmary, NHS Greater Glasgow and Clyde; M Biddle, Marie Kearns, Eva Weiler-Mithoff, Ben Chew, Andy Malyon, John Scott, David McGill, Iain Mackay. Glenfield Hospital, University Hospitals of Leicester; Salena Bains, Sara Barrows, Tim Rattay, Simon Pilgrim, Sheila Shokuhi, Kelly Lambert, Frances Kenny, Kalliope Valassiadou, Monika Kaushik, Jaroslaw Krupa, Dimitris Dragoumis. Good Hope Hospital, Heart of England NHS Foundation Trust; Quratul ain, Pavlos Lampropoulos, Sarah Moss, Haitham Khalil, Anwar Haq, Balapathiran Balasubramanian. Guy's and St Thomas' NHS Foundation Trust; Petros Charalampoudis, Hisham Hamed, Ashutosh Kothari, Tibor Kovacs, Michael Douek. Harrogate and District NHS Foundation Trust; Iftikhar Mehmood, Biswajit Ray, Matthew Adelekan. Homerton University Hospital NHS Foundation Trust; Laura Humphreys, Salim Tayeh, Christina Choy, Laila Parvanta. Istituto Oncologico Veneto, Padova, Italy; Silvia Michieletto, Tania Saibene. James Paget University Hospitals NHS Foundation Trust; James O'Brien, Sue Down, Sarah Downey, Jerome Pereira. Lincoln County Hospital, United Lincolnshire Hospitals NHS Trust; A S Sami, Anzors Gvaramadze, Jibril A Jibril, Dinesh Thekkinkattil. Llanelli Peony Breast Unit; S Udayasankar, Saira Khawaja, Yousef Shariaha, Simon Holt. Luton and Dunstable University Hospital; Ruth James, Hirah Rizki, Katharine Kirkpatrick, Duraisamy Ravichandran, Deepak Shrestha. Maidstone and Tunbridge Wells NHS Trust; Ellora Barua, Deepika Akolekar. Mid Cheshire Hospitals NHS Foundation Trust; Ahmed Hamad, Eleftheria Kleidi, Susan Hignett, Vanessa Pope, Salma Naseem. Milton Keynes University Hospital NHS Foundation Trust; Jennifer Isherwood, Rachel Soulsby, Amanda Taylor, Kian Chin. Morriston Hospital, Abertawe Bro Morgannwg University Health Board; Dai Nguyen. Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust; Francesca Guest, Amanda Thorne. Nevill Hall Hospital, Aneurin Bevan University Health Board; Valentina Lefemine. Norfolk and Norwich University Hospitals NHS Foundation Trust; Chris Kirchhoff, Declan C Murphy, Michelle Lo, Ruth Harcourt, Simon J Pain, Maged I Hussien, Katalin Zechmeister, E.M. Sassoon, Andrea Figus, Richard M Haywood, Rozina Ali, Susanna Alexander, Adrian Harnett, Konstantinos Geropantas, Daniel Epurescu. North Middlesex University Hospital; Rebecca Lewis, Oladapo Fafemi, Jasdeep Gahir, Tasha Gandamihardja. Nottingham Breast Institute, Nottingham University Hospitals NHS Trust; Jennett Kelsall, Nazli Muhibullah, Charlene Otieno, Fayyaz Mazari, Marta Dauria, Lisa Whisker, Douglas Macmillan, Eleanor Gutteridge, Tuabin Rasheed, Hazem Khout, Kristjan Asgeirsson, Stephen McCulley. Ospedale Santa Chiara, University of Pisa, Italy; Maria Donatella Mariniello, Manuela Roncella, Matteo Ghilli, Livio Colizzi, Elena Rossetti, Lo Russo Marzia, Loredana Fustaino, Alessandro Quattrini Li. Oxford University Hospitals NHS Foundation Trust; Kate L Harvey, Rebecca Windle, Dionysios Dennis Remoundos, Pankaj Roy, Gael MacLean, Asha Adwani. Peterborough City Hospital, North West Anglia NHS Foundation Trust; Elena Popa, Steven Goh, Geeta Shetty. Poole Hospital NHS Foundation Trust; Sarah Clark. Portsmouth Hospitals NHS Trust; Lorenzo Bernaudo, Avi Agrawal, Lucy Mansfield. Princess Alexandra Hospital NHS Trust; Sally Tebbal, Ashraf Patel, Veronica Grassi. Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust; Ojas Pujji, Kathryn Hamnett, Naren Basu. Royal Bolton Hospital, Bolton NHS Foundation Trust; Emily Granger, Michael Durbar, Panagiotis Pikoulas, Clare Garnsey, Philip Walker, Angela J Vollermere, Ioannis Michalakis. Royal Devon and Exeter NHS Foundation Trust; Robin Jones, Mina Youssef, Charlotte Ives, Mohammad Masood, Julie Dunn, Sisse Olsen, Douglas Ferguson, Rachel Tillett. Royal Free London NHS Foundation Trust; Anna Allan, Alex Woollard, Rebecca Canny, Alexander Woollard, Afshin Mosahebi, Stephen Hamilton, Shadi Ghali,Daniel Marsh, Jagdeep Chana, Nilesh Sojitra, Ibby Younis. Royal Hampshire County Hospital, Hampshire Hospitals NHS Foundation Trust; Dick Rainsbury, Natalie Chand, Vasileios Kalles, Anne Stebbing, Kevin Harris, Siobhan Laws. Royal Liverpool and Broadgreen University Hospitals NHS Trust; Chris Holcombe, Anne Tansley, Geraldine Mitchell, Emma de Sousa, Julia Henderson, Mysore Chandrashekar. Royal Marsden NHS Foundation Trust; Bernadette Pereira, Chloe Constantinou, Dalia Elfadl, Foivos Irakleidis, Izaro Hernan, Miriam Byrne, Natalie To, Rachel O'Connell, Jennifer Rusby, Peter Barry, Katerine Krupa, William Allum, Fiona MacNeill, Nicola Roche, Gerald Gui, Kelvin Ramsey, Paul Harris, Stuart James, Kieran Power. Royal United Hospitals Bath NHS Foundation Trust; Shelley Potter, Richard Sutton, Jamie McIntosh, Nicola Laurence. Royal Victoria Infirmary, Newcastle Upon Tyne Hospitals NHS Foundation Trust; Louise MacLennan, Robert Milligan, Henry Cain, Adam Critchley, Joe O'Donoghue, Loraine Kalra, Nick Collis. Salisbury NHS Foundation Trust; Gina Weston-Petrides, Roanne Fiddes, Victoria Brown, Anna Aertssen, Diana Slade-Sharman, Mansoor Khan, Caroline McGuiness. Sant'Andrea Hospital of Rome; Vittoria Amorosi, Santanelli di Pompeo Fabio. St Bartholomew's Hospital, Barts Health NHS Trust; Georgios Exarchos, Natasha Jiwa, Jennifer Hu, Serena Ledwidge, Laura Johnson, Anthony Peel, Naseem Dhooma. St Vincent's University Hospital, Dublin; Eric Farrell, Liam Devane, Ruth Tevlin, Enda McDermott, Ruth Prichard, Denis Evoy, Jane Rothwell, James Geraghty, Colin Morrison, Catriona Lawlor. St. James University Hospital, The Leeds Teaching Hospitals NHS Trust; Fiona Langlands, Lauren Taylor, Philip Turton, Raj Achuthan, Kieran Horgan, Shireen Mckenzie, Brian Hogan, Mark Lansdown, Channegowda Navin. The Ipswich Hospital NHS Trust; Liz Sherwin, Caroline Mortimer, Neeraj Garg. The Mid Yorkshire Hospitals NHS Trust; Rahma Adam, Tahera Arif, Zbigniew Kryjak, Deedar Ali, Ravi Sowdi. The Royal Wolverhampton NHS Trust; Elena Fage, Senthurun Mylvaganam, Pilar Matey, Raghavan Vidya, Tapan Sircar. University Hospital of North Tees; Oubida Asaad, Pud Bhaskar, Matei Dordea. University Hospital of South Manchester; Ada Chrysafi, Damian McCartan, Rajiv Dave, Rachel Foster, Rebecca Wilson, Sylvia Okwemba, Yousef Majeed, Ciara O'Brien, Vinod Mathen, John Murphy, Nicola Barnes, Ashu Gandhi, James Harvey, Cliona C Kirwan, Richard Johnson. University Hospitals Coventry & Warwickshire; Krupali Patel, Maria Dalmau Ribas, Natali Vigneswaran, Tom Challoner, Joanna Skillman, Alan Park, Maged Rizkalla, Abigail Tomlins, Kat McEvoy. University Hospitals of North Midlands NHS Trust; Sadaf Jafferbhoy, Soni Soumian, Sankaran Narayanan, Robert Kirby. West Hertfordshire Hospitals NHS Trust; Sladana Bajrusevic, Joseph Maalo, Michalis Charalambous, Lee Min Lai, Kelvin Chong , Simon Thomson, Sherif Monib. Whiston Hospital, St Helens and Knowsley Teaching Hospitals NHS Trust; Leena Chagla, Riccardo Audisio, Rieka Taghizadeh, Azhar Iqbal. Wirral University Teaching Hospital NHS Foundation Trust; Karen James, Maria Callaghan, Shabbir Poonawala, Jonathan Lund, Raman Vinayagam. Worcestershire Acute Hospitals NHS Trust; Sadaf Jafferbhoy, Steven Thrush, Rachel Bright Thomas, Michelle Mullan, Jevan Taylor. York Teaching Hospital NHS Foundation Trust; Ryo Yoshimura, Tom Mathew, Ben Mancey Jones, Kailas Munot, Rana Nasr, Jenny Piper, Deena El-Sharief. Zagazig University Hospital, Egypt; Mohammed Mustafa.
§Members of the iBRA-2 Steering Group, the Breast Reconstruction Research Collaborative and Mammary Fold Academic and Research Collaborative are PUBMED citable collaborators and are listed at the end of this manuscript.
TR is an NIHR Clinical Lecturer and SP is an NIHR Clinician Scientist.
Corresponding author: Dr Tim Rattay, Leicester Cancer Research Centre, University of Leicester, Clinical Sciences Building, Leicester LE2 2LX, UK, [email protected]
Previous communications: Earlier versions of this analysis were presented at the British Association of Surgical Oncology (BASO) Annual Scientific Meeting on 4th November 2018, and at the UK Association of Breast Surgery Conference on 13th May 2019, abstract published in Eur J Surg Oncol (2019) 45 (5): 878. https://doi.org/10.1016/j.ejso.2019.01.190.