The compressive strength of concrete confined with spiral stirrups was an important parameter to evaluate the load-bearing capacity of concrete columns. The confinement provided by spiral stirrups let concrete under the triaxial compression state and improved the compressive strength of concrete. However, the relationships between concrete and stirrups were complex and the existing prediction models for evaluating the compressive strength of confined concrete were various. In this paper, an adaptive neural-fazzy inferenxe system (ANFIS) model was developed to evaluate the compressive strength of concrete confined with stirrups. A set of 231 experimental results of concrete confined with spiral stirrups were collected from the previous studies to establish a reliable database. The investigated parameters included the aspect ratio of specimens, the diameter, spacing, yield strength, and volumetric ratio of stirrups, the ratio of longitudinal reinforcement, and the compressive strength of concrete. The results showed that the ANFIS model predicted the compressive strength of confined concrete accurately. By comparing with existing models, the proposed ANFIS model had high applicable and reliability. The effects of the investigated parameters on the compressive strength of concrete were analyzed based on the proposed ANFIS model.