M. Yam, A.L. Engel, Y. Wang, S. Zhu, A. Hauer, R. Zhang, D. Lohner, J. Huang, M. Dinterman, C. Zhao, J.R. Chao, J. Du, Proline mediates metabolic communication between retinal pigment epithelial cells and the retina, J Biol Chem, 294 (2019) 10278-10289.
 M.J. Radeke, C.M. Radeke, Y.H. Shih, J. Hu, D. Bok, L.V. Johnson, P.J. Coffey, Restoration of mesenchymal retinal pigmented epithelial cells by TGFbeta pathway inhibitors: implications for age-related macular degeneration, Genome medicine, 7 (2015) 58.
 S. Tawara, H. Shimokawa, Progress of the study of rho-kinase and future perspective of the inhibitor, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 127 (2007) 501-514.
 H. Shimokawa, A. Takeshita, Rho-kinase is an important therapeutic target in cardiovascular medicine, Arteriosclerosis, thrombosis, and vascular biology, 25 (2005) 1767-1775.
 L. Van Aelst, C. D'Souza-Schorey, Rho GTPases and signaling networks, Genes & development, 11 (1997) 2295-2322.
 K.P. Garnock-Jones, Ripasudil: first global approval, Drugs, 74 (2014) 2211-2215.
 S. Zandi, S. Nakao, K.H. Chun, P. Fiorina, D. Sun, R. Arita, M. Zhao, E. Kim, O. Schueller, S. Campbell, M. Taher, M.I. Melhorn, A. Schering, F. Gatti, S. Tezza, F. Xie, A. Vergani, S. Yoshida, K. Ishikawa, M. Yamaguchi, F. Sasaki, R. Schmidt-Ullrich, Y. Hata, H. Enaida, M. Yuzawa, T. Yokomizo, Y.B. Kim, P. Sweetnam, T. Ishibashi, A. Hafezi-Moghadam, ROCK-isoform-specific polarization of macrophages associated with age-related macular degeneration, Cell reports, 10 (2015) 1173-1186.
 R. Yamagishi-Kimura, M. Honjo, T. Komizo, T. Ono, A. Yagi, J. Lee, K. Miyata, T. Fujimoto, T. Inoue, H. Tanihara, J. Nishida, T. Uchida, Y. Araki, M. Aihara, Interaction Between Pilocarpine and Ripasudil on Intraocular Pressure, Pupil Diameter, and the Aqueous-Outflow Pathway, Investigative ophthalmology & visual science, 59 (2018) 1844-1854.
 N. Okumura, Y. Okazaki, R. Inoue, K. Kakutani, S. Nakano, S. Kinoshita, N. Koizumi, Effect of the Rho-Associated Kinase Inhibitor Eye Drop (Ripasudil) on Corneal Endothelial Wound Healing, Investigative ophthalmology & visual science, 57 (2016) 1284-1292.
 J. Yang, F. Ruan, Z. Zheng, Ripasudil Attenuates Lipopolysaccharide (LPS)-Mediated Apoptosis and Inflammation in Pulmonary Microvascular Endothelial Cells via ROCK2/eNOS Signaling, Medical science monitor : international medical journal of experimental and clinical research, 24 (2018) 3212-3219.
 Y. Zhong, C. Yu, W. Qin, LncRNA SNHG14 promotes inflammatory response induced by cerebral ischemia/reperfusion injury through regulating miR-136-5p /ROCK1, Cancer gene therapy, 26 (2019) 234-247.
 G. Deng, Y. Gao, Z. Cen, J. He, B. Cao, G. Zeng, S. Zong, miR-136-5p Regulates the Inflammatory Response by Targeting the IKKbeta/NF-kappaB/A20 Pathway After Spinal Cord Injury, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 50 (2018) 512-524.
 V. Compan, F. Martin-Sanchez, A. Baroja-Mazo, G. Lopez-Castejon, A.I. Gomez, A. Verkhratsky, D. Brough, P. Pelegrin, Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling, Journal of immunology (Baltimore, Md. : 1950), 194 (2015) 1261-1273.
 K. Mondal, N. Mandal, Role of Bioactive Sphingolipids in Inflammation and Eye Diseases, Advances in experimental medicine and biology, 1161 (2019) 149-167.
 W. Zhou, J.H. Quan, F.F. Gao, H. Ismail, Y.H. Lee, G.H. Cha, Modulated Gene Expression of Toxoplasma gondii Infected Retinal Pigment Epithelial Cell Line (ARPE-19) via PI3K/Akt or mTOR Signal Pathway, The Korean journal of parasitology, 56 (2018) 135-145.
 K.L. Pennington, M.M. DeAngelis, Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors, Eye and vision (London, England), 3 (2016) 34.
 A. Panday, M.E. Inda, P. Bagam, M.K. Sahoo, D. Osorio, S. Batra, Transcription Factor NF-kappaB: An Update on Intervention Strategies, Archivum immunologiae et therapiae experimentalis, 64 (2016) 463-483.
 K. Schweitzer, P.M. Bozko, W. Dubiel, M. Naumann, CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha, The EMBO journal, 26 (2007) 1532-1541.
 T. Komizo, T. Ono, A. Yagi, K. Miyata, M. Aihara, Additive intraocular pressure-lowering effects of the Rho kinase inhibitor ripasudil in Japanese patients with various subtypes of glaucoma, Japanese journal of ophthalmology, 63 (2019) 40-45.
 M. Yasuda, K. Takayama, T. Kanda, M. Taguchi, H. Someya, M. Takeuchi, Comparison of intraocular pressure-lowering effects of ripasudil hydrochloride hydrate for inflammatory and corticosteroid-induced ocular hypertension, PLoS One, 12 (2017) e0185305.
 D. Li, W. Ren, Z. Jiang, L. Zhu, Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury, Molecular medicine reports, 18 (2018) 4399-4409.
 Q. Wang, R. Imamura, K. Motani, H. Kushiyama, S. Nagata, T. Suda, Pyroptotic cells externalize eat-me and release find-me signals and are efficiently engulfed by macrophages, International immunology, 25 (2013) 363-372.
 S. Kanno, S. Hirano, S. Chiba, H. Takeshita, T. Nagai, M. Takada, K. Sakamoto, T. Mukai, The role of Rho-kinases in IL-1beta release through phagocytosis of fibrous particles in human monocytes, Archives of toxicology, 89 (2015) 73-85.