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Research article
Increased MMP2 contributes to the diagnosis and prognosis of lung cancer
Qiufang Jiang
Jining Medical University
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: Matrix metalloproteinase 2 (MMP2) has been found to be correlated with the occurrence and development of lung cancer; the aim of this study was to investigate the clinical significance and prognosis value of MMP2 expression in lung cancer.
Methods: The expression of MMP2 in lung cancer tissues was tested by immunohistochemistry and its serum level was tested by enzyme-linked immunosorbent assay.
Results: The expression of MMP2 was higher in lung cancer tissues and serum of lung cancer patients, and increased MMP2 was associated with tumor size, lymph node metastasis, advanced stage and postoperative survival time (p<0.05). The sensitivity and specificity of serum MMP2 for distinguishing lung cancer from lung benign diseases were 96.51% and 65.85%; and for distinguishing lung cancer from normal individuals were 97.67% and 75%.
Conclusions: Increased serum MMP2 could be considered as a potential molecular biomarker for diagnosis and prognosis of lung cancer.
Keywords
Lung cancer, matrix metalloproteinase 2, MMP2, serum, diagnosis, prognosis
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This is a preprint. It has not completed peer review.
Research article
Increased MMP2 contributes to the diagnosis and prognosis of lung cancer
Qiufang Jiang
Jining Medical University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 13 Jan, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Matrix metalloproteinase 2 (MMP2) has been found to be correlated with the occurrence and development of lung cancer; the aim of this study was to investigate the clinical significance and prognosis value of MMP2 expression in lung cancer.
Methods: The expression of MMP2 in lung cancer tissues was tested by immunohistochemistry and its serum level was tested by enzyme-linked immunosorbent assay.
Results: The expression of MMP2 was higher in lung cancer tissues and serum of lung cancer patients, and increased MMP2 was associated with tumor size, lymph node metastasis, advanced stage and postoperative survival time (p<0.05). The sensitivity and specificity of serum MMP2 for distinguishing lung cancer from lung benign diseases were 96.51% and 65.85%; and for distinguishing lung cancer from normal individuals were 97.67% and 75%.
Conclusions: Increased serum MMP2 could be considered as a potential molecular biomarker for diagnosis and prognosis of lung cancer.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5