The isolation strategy and quarantine strategy played a crucial role in the prevention of the Corona Virus Disease 2019 in China.This paper establishes a two-layer network model that couples epidemics and the behavior of individuals based on game theory.We calculated the basic reproduction number of the infectious disease, and analyzed the existence and stability of the positiveequilibrium point in the behavioral dynamic model. Through simulation, we adjusted the behavior parameters to fit the actualdata, and then analyzed the sensitivity of each parameter to the system. The contradiction between national strategy andindividual behavior was found in the simulation process. The simulation results show that increasing the awareness of peoplecan accelerate changes in behavior, and improving the efficiency of working at home can reduce the relative loss of isolation,all of which can reduce the severity of the infectious disease.