Gastric cancer is found at a rate of 2.4 to 3.5 percent in Indonesia, with the majority of cases discovered at an advanced stage. Cyclin D1 is a protein that promotes cancer cell growth. It has been shown to be expressed in a variety of cancers, including stomach cancer. A recent study of cyclin D1 in gastric cancer has been associated with lymph node involvement, metastasis, poor prognosis, and lack of response to platinum chemotherapy. This study aims to determine the relationship between cyclin D1 expression and clinicopathological features in gastric cancer. This cross-sectional study used medical records and paraffin blocks of gastric cancer patients at Cipto Mangunkusumo General Hospital, Jakarta, in 2015–2020. Demographic data, clinical characteristics, radiological findings, histopathological features, and cyclin D1 expression were collected and examined. Data was collected from 39 subjects. Most of the subjects experienced eating disorders (69.23%), weight loss (76.92%), melena (53.85%), and anemia (51.28%). Tumor locations were mostly found in the cardia and corpus of the gaster. Overexpression of cyclin D1 was found in 30.77% of cases. Cyclin D1 expression was greater in subjects with liver metastases (50% vs. 14.8%, p 0.04). Cyclin D1 expression was not associated with tumor location, TNM stage, and histopathological findings.