This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Lihong Li
Corresponding Author
ORCiD: https://orcid.org/0000-0003-4991-9037
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: Sepsis-associated encephalopathy (SAE) is related to an increased in-hospital mortality in patients with sepsis. We aim to establish a user-friendly nomogram for individual prediction of in-hospital death probability in patients with SAE.
Methods: Data were retrospectively retrieved from the Medical Information Mart for Intensive Care (MIMIC III) open source clinical database. SAE was defined by a Glasgow Coma Score (GCS) <15 at the presence of sepsis. Prediction model with a nomogram was constructed in the training set by Logistic regression analysis and then internally validated. A decision curve analysis (DCA) was performed to evaluate the net benefit of intervention with the nomogram.
Results: A total of 669 and 287 patients with SAE were randomly assigned to training set and internal validation set according to an allocation ratio of 7:3, respectively. Parameters eligible for the nomogram included age, Sequential Organ Failure Assessment (SOFA) score, red blood cell distribution width (RDW) and the mean values of heart rate, temperature and respiratory rate at first day of ICU admission. The nomogram exhibited good discrimination with an area under the receiver operating characteristic curve (AUROC) of 0.773 (95%CI: 0.729–0.818) in the training set and 0.741 (95%CI 0.673–0.809) in the validation set, respectively. Calibration of the derived model was also excellent, with Brier score of 0.136 (95%CI: 0.12 –0.153) and 0.168 (95%CI: 0.144–0.192) in both sets. The DCA of the nomogram indicated greater net benefit than SOFA. X-tile analysis showed that the nomogram can clearly stratify patients into three subgroups with different risks of hospital death.
Conclusions: The nomogram presents excellent performance in predicting in-hospital mortality of SAE patients, which can guide the prevention of SAE progression and may be more beneficial once specific treatments towards SAE are developed.
Keywords
Sepsis, Sepsis-associated encephalopathy, In-hospital mortality, Nomogram, Sequential Organ Failure Assessment Score
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Lihong Li
Corresponding Author
ORCiD: https://orcid.org/0000-0003-4991-9037
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 15 Jan, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Critical Care & Emergency Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Sepsis-associated encephalopathy (SAE) is related to an increased in-hospital mortality in patients with sepsis. We aim to establish a user-friendly nomogram for individual prediction of in-hospital death probability in patients with SAE.
Methods: Data were retrospectively retrieved from the Medical Information Mart for Intensive Care (MIMIC III) open source clinical database. SAE was defined by a Glasgow Coma Score (GCS) <15 at the presence of sepsis. Prediction model with a nomogram was constructed in the training set by Logistic regression analysis and then internally validated. A decision curve analysis (DCA) was performed to evaluate the net benefit of intervention with the nomogram.
Results: A total of 669 and 287 patients with SAE were randomly assigned to training set and internal validation set according to an allocation ratio of 7:3, respectively. Parameters eligible for the nomogram included age, Sequential Organ Failure Assessment (SOFA) score, red blood cell distribution width (RDW) and the mean values of heart rate, temperature and respiratory rate at first day of ICU admission. The nomogram exhibited good discrimination with an area under the receiver operating characteristic curve (AUROC) of 0.773 (95%CI: 0.729–0.818) in the training set and 0.741 (95%CI 0.673–0.809) in the validation set, respectively. Calibration of the derived model was also excellent, with Brier score of 0.136 (95%CI: 0.12 –0.153) and 0.168 (95%CI: 0.144–0.192) in both sets. The DCA of the nomogram indicated greater net benefit than SOFA. X-tile analysis showed that the nomogram can clearly stratify patients into three subgroups with different risks of hospital death.
Conclusions: The nomogram presents excellent performance in predicting in-hospital mortality of SAE patients, which can guide the prevention of SAE progression and may be more beneficial once specific treatments towards SAE are developed.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
This is a list of supplementary files associated with this preprint. Click to download.
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