Cardiovascular diseases(CVD) and frailty are common health problems among the elderly. This research aims to investigate the hotspots and frontiers of the field of cardiovascular diseases with frailty. Data of publications between 2000 and 2021 was collected from the Web of Science(WoS) and CiteSpace was used for analysing the hotspots and frontiers of cardiovascular diseases with frailty research from high-impact countries, institutions, authors, cited-references, cited-journals, high-frequency keywords and burst keywords. The results showed that the United States, England and Canada were the leading countries in research of cardiovascular diseases with frailty. Other countries and regions lagged behind these developed countries. There is a need to establish cooperation between developed countries and developing countries. Research hotspots focused on frailty in the elderly with CVD, exercise intervention, assessment for CVD patients with frailty, quality of life and common diseases related to CVD with frailty. The frontier fields include care and intervention of CVD patients with frailty, social frailty and validation of CVD with frailty.