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Research Article
The association between Helicobacter pylori infection and food intolerance in western China
Ping Shuai
Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
Introduction
Helicobacter pylori (H. pylori) has been found to be associated with extragastrointestinal diseases while the studies on its association with food intolerance are rare. In our study, we tried to explore the relationship between H. pylori infection and food intolerance.
Methods
We retrospectively analyzed the physical examination data of 21,822 subjects from February 2014 to December 2018 in this study. H. pylori infection was determined by 13C urea breath test. The food specific IgG in serum were detected to assess the food tolerance status of egg, milk and wheat.
Results
The total infection rate of H. pylori was 39.3% and the total food intolerance rates of egg, milk and wheat were 25.2%, 9.0% and 4.7%, respectively. The infection rate of H. pylori was higher in males than that in females, while the intolerance rates were lower in males than that in females. The infection rates of H. pylori increased with age except for people over sixty, while the intolerance rates decreased. In H. pylori positive group, the intolerance rates were lower than that in the H. pylori negative group. At the same level of food intolerance, the intolerance rates in H. pylori positive group were lower than that in H. pylori negative group. Multivariate Logistic regression analysis showed that H. pylori infection was negatively correlated with intolerance of egg, milk and wheat (OR value of egg 0.844–0.873, milk 0.741–0.751, wheat 0.762–0.801).
Conclusions
H. pylori infection was negatively correlated with intolerance of egg, milk and wheat in Sichuan, western China.
Keywords
food intolerance, Helicobacter pylori, gut microbiota, humoral immunity
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On 05 Jan, 2021
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This preprint is under consideration at Scientific Reports. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
The association between Helicobacter pylori infection and food intolerance in western China
Ping Shuai
Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 21 Dec, 2020
No community comments so far
Review #3 received
Received 14 Jan, 2021
Review #5 received
Received 14 Jan, 2021
Review #4 received
Received 14 Jan, 2021
Review #2 received
Received 14 Jan, 2021
Review #1 received
Received 14 Jan, 2021
Reviewer #4 agreed
On 05 Jan, 2021
Reviewer #1 agreed
On 05 Jan, 2021
Reviewer #6 agreed
On 05 Jan, 2021
Reviewer #5 agreed
On 05 Jan, 2021
Reviewer #3 agreed
On 05 Jan, 2021
Reviewer #2 agreed
On 05 Jan, 2021
Reviewers invited
Invitations sent on 05 Jan, 2021
Editor assigned
On 31 Dec, 2020
Editor invited
On 17 Dec, 2020
Submission checks complete
On 17 Dec, 2020
First submitted
On 05 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Introduction
Helicobacter pylori (H. pylori) has been found to be associated with extragastrointestinal diseases while the studies on its association with food intolerance are rare. In our study, we tried to explore the relationship between H. pylori infection and food intolerance.
Methods
We retrospectively analyzed the physical examination data of 21,822 subjects from February 2014 to December 2018 in this study. H. pylori infection was determined by 13C urea breath test. The food specific IgG in serum were detected to assess the food tolerance status of egg, milk and wheat.
Results
The total infection rate of H. pylori was 39.3% and the total food intolerance rates of egg, milk and wheat were 25.2%, 9.0% and 4.7%, respectively. The infection rate of H. pylori was higher in males than that in females, while the intolerance rates were lower in males than that in females. The infection rates of H. pylori increased with age except for people over sixty, while the intolerance rates decreased. In H. pylori positive group, the intolerance rates were lower than that in the H. pylori negative group. At the same level of food intolerance, the intolerance rates in H. pylori positive group were lower than that in H. pylori negative group. Multivariate Logistic regression analysis showed that H. pylori infection was negatively correlated with intolerance of egg, milk and wheat (OR value of egg 0.844–0.873, milk 0.741–0.751, wheat 0.762–0.801).
Conclusions
H. pylori infection was negatively correlated with intolerance of egg, milk and wheat in Sichuan, western China.
Figure 1
Figure 2