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Research Article
The effect of fibrin glue on the postoperative lymphatic drainage after gastrectomy and D2 dissection: a randomized clinical trial
Ehsanollah RahimiMovaghar
Tehran University of Medical Sciences
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Introduction: Disturbance in the lymphatic drainage during D2 dissection is associated with significant morbidity. We aimed to assess the effect of fibrin glue on reduction of postoperative seroma formation.
Methods: Prospective double-blinded randomized clinical trial with forty patients in each study arm was conducted. All patients diagnosed, staged and became candidate for D2 dissection based on NCCN 2019 guideline for gastric cancer. Intervention group received 1 cc of IFABOND® applied to the surgical bed.
Results: The difference between study groups regarding age, gender, tumor stage was insignificant. (All p values > 0.05). The median of daily drainage volume was 120 milliliter with the first and the third interquartile being 75 and 210 milliliter, respectively for intervention group. The control group had median, the first and the third interquartile of 350, 290 and 420 milliliter. The difference between daily drainage volumes was statistically significant (p value < 0.001). The length of hospital stay was significantly different between two groups and intervention group were discharged sooner (median of 7 Vs 9 days, p value: 0.001).
Conclusion: This study showed possible role of fibrin glue on reducing postoperative seroma formation after gastrectomy and D2 dissection.(IRCT20200710048071N1, 2020.08.16)
Keywords
fibrin glue, gastric cancer, gastrectomy, D2 dissection, lymphatic drainage, seroma.
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CURRENT STATUS: Under Review
Version 1
Posted 23 Dec, 2020
No community comments so far
Review #1 received
Received 07 Jan, 2021
Reviewer #1 agreed
On 28 Dec, 2020
Reviewer #3 agreed
On 28 Dec, 2020
Reviewer #4 agreed
On 28 Dec, 2020
Reviewer #2 agreed
On 28 Dec, 2020
Reviewers invited
Invitations sent on 27 Dec, 2020
Editor assigned
On 22 Dec, 2020
Editor invited
On 22 Dec, 2020
Submission checks complete
On 22 Dec, 2020
First submitted
On 05 Dec, 2020
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This preprint is under consideration at BMC Surgery. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
The effect of fibrin glue on the postoperative lymphatic drainage after gastrectomy and D2 dissection: a randomized clinical trial
Ehsanollah RahimiMovaghar
Tehran University of Medical Sciences
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 23 Dec, 2020
No community comments so far
Review #1 received
Received 07 Jan, 2021
Reviewer #1 agreed
On 28 Dec, 2020
Reviewer #3 agreed
On 28 Dec, 2020
Reviewer #4 agreed
On 28 Dec, 2020
Reviewer #2 agreed
On 28 Dec, 2020
Reviewers invited
Invitations sent on 27 Dec, 2020
Editor assigned
On 22 Dec, 2020
Editor invited
On 22 Dec, 2020
Submission checks complete
On 22 Dec, 2020
First submitted
On 05 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Introduction: Disturbance in the lymphatic drainage during D2 dissection is associated with significant morbidity. We aimed to assess the effect of fibrin glue on reduction of postoperative seroma formation.
Methods: Prospective double-blinded randomized clinical trial with forty patients in each study arm was conducted. All patients diagnosed, staged and became candidate for D2 dissection based on NCCN 2019 guideline for gastric cancer. Intervention group received 1 cc of IFABOND® applied to the surgical bed.
Results: The difference between study groups regarding age, gender, tumor stage was insignificant. (All p values > 0.05). The median of daily drainage volume was 120 milliliter with the first and the third interquartile being 75 and 210 milliliter, respectively for intervention group. The control group had median, the first and the third interquartile of 350, 290 and 420 milliliter. The difference between daily drainage volumes was statistically significant (p value < 0.001). The length of hospital stay was significantly different between two groups and intervention group were discharged sooner (median of 7 Vs 9 days, p value: 0.001).
Conclusion: This study showed possible role of fibrin glue on reducing postoperative seroma formation after gastrectomy and D2 dissection.(IRCT20200710048071N1, 2020.08.16)