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Article
Marco Capogrosso
University of Pittsburgh
Corresponding Author
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Regaining arm motor control is critical for people with paralysis. Despite promising results on grasping, no technology could restore effective arm control. Here, we show that electrical stimulation of the cervical spinal cord enabled three monkeys with cervical spinal injury to execute functional arm movements. We designed an epidural interface that engaged surviving spinal circuits via the recruitment of large sensory afferents to produce movement. Simple stimulation bursts produced sustained joint movements which, triggered by movement-related intracortical signals, enabled monkeys with arm paralysis to perform an unconstrained, three-dimensional reach and grasp task. This restoration of voluntary motor control was enabled by the synergistic integration of spared descending commands and electrical stimulation within the spinal cord. The simplicity of this technology promises realistic clinical translation.
Keywords
paralysis, arm motor control
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This preprint is available for download as a PDF.
Yes there is potential Competing Interest. G.C., J.B., S.L., M.C., B.B. and K.Z. hold various patents in relation to the present work. G.C., S.L. and J.B. are founders and shareholders of GTX medical, a company developing an EES-based therapy to restore movement after spinal cord injury.
This is a list of supplementary files associated with this preprint. Click to download.
- Video1.mp4
Video 1
- SupplementaryData.pdf
- Video2.mp4
Video 2
- Video3.mp4
Video 3
- Video4.mp4
Video 4
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Article
Marco Capogrosso
University of Pittsburgh
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 28 Dec, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Regaining arm motor control is critical for people with paralysis. Despite promising results on grasping, no technology could restore effective arm control. Here, we show that electrical stimulation of the cervical spinal cord enabled three monkeys with cervical spinal injury to execute functional arm movements. We designed an epidural interface that engaged surviving spinal circuits via the recruitment of large sensory afferents to produce movement. Simple stimulation bursts produced sustained joint movements which, triggered by movement-related intracortical signals, enabled monkeys with arm paralysis to perform an unconstrained, three-dimensional reach and grasp task. This restoration of voluntary motor control was enabled by the synergistic integration of spared descending commands and electrical stimulation within the spinal cord. The simplicity of this technology promises realistic clinical translation.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
This preprint is available for download as a PDF.
Yes there is potential Competing Interest. G.C., J.B., S.L., M.C., B.B. and K.Z. hold various patents in relation to the present work. G.C., S.L. and J.B. are founders and shareholders of GTX medical, a company developing an EES-based therapy to restore movement after spinal cord injury.
This is a list of supplementary files associated with this preprint. Click to download.
- Video1.mp4
Video 1
- SupplementaryData.pdf
- Video2.mp4
Video 2
- Video3.mp4
Video 3
- Video4.mp4
Video 4
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