| | β(95%CI)P value | β(95%CI)P value | β(95%CI)P value |
Head BMD(g/cm2) | Blood manganese(ug/L) | 0.0165(0.0008,0.0322) 0.318 | -0.053(-0.0684,-0.0376) 0.001 | -0.0593(-0.0775,-0.0411) 0.002 |
| Q1:1.88-7.76 ug/L | Reference | Reference | Reference |
| Q2:7.77-9.69 ug/L | -0.0824(-0.1266,-0.0382) 0.077 | -0.028(-0.0659,0.0099) 0.484 | -0.1261(-0.174,-0.0782) 0.012 |
| Q3:9.70-12.18 ug/L | -0.1396(-0.1838,-0.0954) 0.003 | 0.0123(-0.0257,0.0503) 0.76 | -0.2033(-0.2514,-0.1552) <0.001 |
| Q4:12.19-52.0 ug/L | -1808(-0.225,-0.1366) <0.001 | 0.0641(0.0252,0.103) 0.118 | -0.1984(-0.2484,-0.1484) <0.001 |
| P for trend | 0.0799 |
Head BMC(g) | Blood manganese(ug/L) | ’-0.01685(-0.0326, -0.0012)0.307 | ‘-0.0348(-0.0658, -0.0187)0.04 | ’-0.0468(-0.0658, -0.0278)0.019 |
| Q1:1.88-7.76 ug/L | Reference | Reference | Reference |
| Q2:7.77-9.69 ug/L | ‘-0.1346(-0.1789, -0.0903)0.004 | ’-0.1471(-0.1911, -0.1031)0.002 | ‘-0.1109(-0.1609, -0.0609)0.035 |
| Q3:9.70-12.18 ug/L | ’-0.1119(-0.1561, -0.0677)0.016 | ‘-0.1336(-0.1777, -0.0895)0.004 | ’-0.1831(-0.2333, -0.1329)<0.001 |
| Q4:12.19-52.0 ug/L | ‘-0.0993(-0.1435, -0.0551)0.033 | ’-0.1488(-0.1939, -0.1037)0.002 | ‘-0.1628(-0.215, -0.1106)0.003 |
| P for trend | 0.02 |
Left Arm BMD(g/cm2) | Blood manganese(ug/L) | -0.2316(-0.2468,-0.2164) <0.001 | -0.0759(-0.0872,-0.0646) <0.001 | -0.0665(-0.0799,-0.0531) <0.001 |
| Q1:1.88-7.76 ug/L | Reference | Reference | Reference |
| Q2:7.77-9.69 ug/L | -0.1406(-0.1838,-0.0974) 0.002 | -0.0737(-0.1046,-0.0428) 0.023 | -0.0162(-0.0514,0.019) 0.662 |
| Q3:9.70-12.18 ug/L | -0.2937(-0.3368,-0.2506) <0.001 | -0.1378(-0.1688,-0.1068) <0.001 | -0.121(-0.1563,-0.0859) 0.001 |
| Q4:12.19-52.0 ug/L | -0.604(-0.6472,-0.5608) <0.001 | -0.2169(-0.2486,-0.1852) <0.001 | -0.1807(-0.2174,-0.144) <0.001 |
| P for trend | ༜0.001*** |
Left Arm BMC(g) | Blood manganese(ug/L) | ’-0.257(-0.2721, -0.2419)<0.001 | ‘-0.1035(-0.1139, -0.0931)<0.001 | ’-0.0948(-0.1071, -0.0825)<0.001 |
| Q1:1.88-7.76 ug/L | Reference | Reference | Reference |
| Q2:7.77-9.69 ug/L | ‘-0.1686(-0.2114, -0.1258)<0.001 | ’-0.1071(-0.1354, -0.0788)<0.001 | ‘-0.0755(-0.1079, -0.0431)0.027 |
| Q3:9.70-12.18 ug/L | ’-0.3339(-0.3767, -0.2912)<0.001 | ‘-0.1923(-0.2207, -0.1639)<0.001 | ’-0.1783(-0.2108, -0.1458)<0.001 |
| Q4:12.19-52.0 ug/L | ‘-0.7031(-0.7459, -0.6603)<0.001 | ’-0.3265(-0.3555, -0.2975)<0.001 | ‘-0.2963(-0.3301, -0.2625)<0.001 |
| P for trend | <0.001 |
Left Leg BMD(g/cm2) | Blood manganese(ug/L) | -0.1881(-0.2035,-0.1727)<0.001 | -0.0799(-0.0929,-0.0669) <0.001 | -0.0698(-0.0852,-0.0544) <0.001 |
| Q1:1.88-7.76 ug/L | Reference | Reference | Reference |
| Q2:7.77-9.69 ug/L | -0.1032(-0.1468,-0.0596) 0.025 | -0.0608(-0.0964,-0.0252) 0.105 | -0.0088(-0.0492,0.0316) 0.837 |
| Q3:9.70-12.18 ug/L | -0.2345(-0.2781,-0.1909) <0.001 | -0.1316(-0.1673,-0.0959) <0.001 | -0.1304(-0.171,-0.0898) 0.002 |
| Q4:12.19-52.0 ug/L | -0.4773(-0.5209,-0.4337) <0.001 | -0.2073(-0.2439,-0.1707) <0.001 | -0.1803(-0.225,-0.1381) <0.001 |
| P for trend | ༜0.001*** |
Left Leg BMC(g) | Blood manganese(ug/L) | ‘-0.2421(-0.2573, -0.2269)<0.001 | ’-0.1068(-0.1183, -0.0953)<0.001 | ‘-0.1048(-0.1184, -0.0912)<0.001 |
| Q1:1.88-7.76 ug/L | Reference | Reference | Reference |
| Q2:7.77-9.69 ug/L | ’-0.1491(-0.1921, -0.1061)0.001 | ‘-0.094(-0.1255, -0.0625)0.005 | 0.16 |
| Q3:9.70-12.18 ug/L | ‘-0.2977(-0.3407, -0.2547)<0.001 | ’-0.1661(-0.1977, -0.1345)<0.001 | <0.001 |
| Q4:12.19-52.0 ug/L | ’-0.6524(-0.6954, -0.6094)<0.001 | ‘-0.318(-0.3503, -0.2857)<0.001 | <0.001 |
| P for trend | <0.001 |
Pelvis BMD(g/cm2) | Blood manganese(ug/L) | -0.0816(-0.066,-0.0972) <0.001 | -0.0515(-0.067,-0.036) 0.002 | -0.0439(-0.0623,-0.0255) 0.023 |
| Q1:1.88-7.76 ug/L | Reference | Reference | Reference |
| Q2:7.77-9.69 ug/L | -0.0608(-0.105,-0.0166) 0.191 | -0.0601(-0.1024,-0.0178) 0.178 | 0.0046(-0.0438,0.053) 0.927 |
| Q3:9.70-12.18 ug/L | -0.0686(-0.1127,-0.0245) 0.139 | -0.0619(-0.1044,-0.0194) 0.166 | -0.0662(-0.1148,-0.0176) 0.196 |
| Q4:12.19-52.0 ug/L | -0.2266(-0.2707,-0.1825) <0.001 | -0.1503(-0.1937,-0.1069) 0.001 | -0.1366(-0.1871,-0.0861) 0.01 |
| P for trend | ༜0.001*** |
Pelvis BMC(g) | Blood manganese(ug/L) | ‘-0.1768(-0.1922, -0.1614)<0.001 | ’-0.1042(-0.1183, -0.0901)<0.001 | ‘-0.1083(-0.1249, -0.0917)<0.001 |
| Q1:1.88-7.76 ug/L | Reference | Reference | Reference |
| Q2:7.77-9.69 ug/L | ’-0.135(-0.1786, -0.0914)0.003 | ‘-0.1133(-0.1519, -0.0747)0.005 | ’-0.0639(-0.1075, -0.0203)0.164 |
| Q3:9.70-12.18 ug/L | ‘-0.2222(-0.2658, -0.1786)<0.001 | ’-0.1462(-0.1849, -0.1075)<0.001 | ‘-0.136(-0.1798, -0.0922)0.003 |
| Q4:12.19-52.0 ug/L | ’-0.5003(-0.5439, -0.4567)<0.001 | ‘-0.3168(-0.3564, -0.2772)<0.001 | ’-0.3146(-0.3601, -0.2691)<0.001 |
| P for trend | <0.001 |
Trunk Bone BMD(g/cm2) | Blood manganese(ug/L) | -0.1324(-0.1479,-0.1169) <0.001 | -0.0872(-0.1024,-0.072) <0.001 | -0.0859(-0.104,-0.0679) <0.001 |
| Q1:1.88-7.76 ug/L | Reference | Reference | Reference |
| Q2:7.77-9.69 ug/L | -0.1022(-0.1462,-0.0582) 0.027 | -0.0919(-0.1336,-0.0502) 0.036 | -0.0383(-0.0859,0.0093) 0.44 |
| Q3:9.70-12.18 ug/L | -0.1748(-0.2187,-0.1309) <0.001 | -0.1372(-0.179,-0.0954) 0.002 | -0.1458(-0.1936,-0.098) 0.004 |
| Q4:12.19-52.0 ug/L | -0.3645(-0.4084,-0.3206) <0.001 | -0.2504(-0.2931,-0.2077) <0.001 | -0.2393(-0.2891,-0.1895) <0.001 |
| P for trend | ༜0.001*** |
Trunk Bone BMC(g) | Blood manganese(ug/L) | -0.1706(-0.186,-0.1552)༜0.001 | -0.0819(-0.0952,-0.0686)༜0.001 | -0.0852(-0.1009,-0.0695)༜0.001 |
| Q1:1.88-7.76 ug/L | Reference | Reference | Reference |
| Q2:7.77-9.69 ug/L | -0.1012(-0.1448,-0.0576) 0.028 | -0.0777(-0.1139,-0.0415) 0.042 | -0.0329(-0.0743,0.0085) 0.449 |
| Q3:9.70-12.18 ug/L | -0.1884(-0.232,-0.1448) <0.001 | -0.1221(-0.1584,-0.0858) 0.001 | -0.1217(-0.1632,-0.0802) 0.005 |
| Q4:12.19-52.0 ug/L | -0.4775(-0.5211,-0.4339)<0.001 | -0.2583(-0.2946,-0.222)<0.001 | -0.2484(-0.2916,-0.2052)<0.001 |
| P for trend | <0.001 |
Total body BMD(g/cm2) | Blood manganese(ug/L) | -0.1409(-0.1564,-0.1254)<0.001 | -0.0823(-0.0974,-0.0672)<0.001 | -0.0789(-0.0968,-0.0610)<0.001 |
| Q1:1.88-7.76 ug/L | Reference | Reference | Reference |
| Q2:7.77-9.69 ug/L | -0.1365(-0.1804,-0.0926) 0.003 | -0.1168(-0.158,-0.0756) 0.007 | -0.0523 (-0.0993,-0.0053) 0.29 |
| Q3:9.70-12.18 ug/L | -0.2172(-0.261,-0.1734) <0.001 | -0.1641(-0.2054,-0.1228) <0.001 | -0.1826 (-0.2298,-0.1354) <0.001 |
| Q4:12.19-52.0 ug/L | -0.3847(-0.4286,-0.3408) <0.001 | -0.2389(-0.281,-0.1967) <0.001 | -0.2188(-0.2679,-0.1697) <0.001 |
| P for trend | ༜0.001*** |
Total body BMC(g) | Blood manganese(ug/L) | ‘-0.217(-0.2323, -0.2017)<0.001 | ’-0.1022(-0.1146, -0.0898)<0.001 | ‘-0.1025(-0.1172, -0.0878)<0.001 |
| Q1:1.88-7.76 ug/L | Reference | Reference | Reference |
| Q2:7.77-9.69 ug/L | ’-0.1606(-0.2038, -0.1174)<0.001 | ‘-0.1189(-0.1528, -0.085)<0.001 | ’-0.0717(-0.1104, -0.033)0.078 |
| Q3:9.70-12.18 ug/L | ‘-0.2823(-0.3255, -0.2391)<0.001 | ’-0.1796(-0.2136, -0.1456)<0.001 | ‘-0.1784(-0.2173, -0.1395)<0.001 |
| Q4:12.19-52.0 ug/L | ’-0.6033(-0.6465, -0.5601)<0.001 | ‘-0.3211(-0.3558, -0.2864)<0.001 | ’-0.3068(-0.3472, -0.2664)<0.001 |
| P for trend | <0.001 |