Funding:
The project National Pandemic Cohort Network (NAPKON) is part of the Network University Medicine (NUM) and was funded by the German Federal Ministry of Education and Research (BMBF) (FKZ: 01KX2021).
Parts of the infrastructure of the Würzburg study site were supported by the Bavarian Ministry of Research and Art to support Corona research projects.
Parts of the NAPKON project suite and study protocols of the Cross-Sectoral cohort platform are based on projects funded by the German Center for Infection Research (DZIF).
Part of the infrastructure for the Population-Based Platform received funding of the State of Schleswig Holstein (COVIDOM) and DFG Exzellenzcluster.
Conflicts of interest/Competing interests
Dr. Heuschmann reports grants from German Ministry of Research and Education, during the conduct of the study; research grants from German Ministry of Research and Education, European Union, Charité – Universitätsmedizin Berlin, Berlin Chamber of Physicians, German Parkinson Society, University Hospital Würzburg, Robert Koch Institute, German Heart Foundation, Federal Joint Committee (G-BA) within the Innovationfond, German Research Foundation, Bavarian State (ministry for science and the arts), German Cancer Aid, Charité – Universitätsmedizin Berlin (within Mondafis; supported by an unrestricted research grant to the Charité from Bayer), University Göttingen (within FIND-AF randomized; supported by an unrestricted research grant to the University Göttingen from Boehringer-Ingelheim), University Hospital Heidelberg (within RASUNOA-prime; supported by an unrestricted research grant to the University Hospital Heidelberg from Bayer, BMS, Boehringer-Ingelheim, Daiichi Sankyo), outside the submitted work.
Dr. Bahmer reports grants from the German Center for Lung Research (DZL) and fees for lecturing, andvice and travel expenses from AstraZeneca, GlaxoSmithKline. Novartis, Chiesi, Boehringer Ingelheim, MSD, Roche.
Dr. Bellinghausen reports grants or contracts from Gilead Sciences.
Dr. Hanses reports having received fees for presentations and lectures for DGINA, Akademie für Infektionsmedizin, and participation on the advisory boards for MSD, GSK and Sobi.
Dr. Keil reports grants from European Union; German Research Foundation; German Federal Ministry of Research and Education; Innovationsfonds by the Federal Joint Committee (G-BA); and the Bavarian State Ministry of Health and Care.
Dr. Pape reports having received support for attending ECCMID 2021 from Advanz Pharma Germany.
Dr. Püntmann reports honoraria for presentations for Byer AG and Siemens AG, and being involved in the ACC Taskforce on long-term sequela of COVID-19 infection.
Dr. Störk reports grants from Federal Ministry of Education and Research for the Comprehensive Heart Failure Center Würzburg.
Dr. Nagel reports grants from Byer AG and NeoSoft Ltd., consulting fees from Bayer AG, honoraria for presentations for Byer AG, Pfizer AG and Siemens Healthineers. He has received payments for expert testimony by Bayer AG, participates in the Advisory board CMR-ICD: NCT04558723, has patents issued and received equipment from MEDIS and NeoSoft.
Dr. Thibeault reports grants from the Deutsche Forschungsgemeinschaft.
Dr. Witzenrath reports grants from Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung, Deutsche Gesellschaft für Pneumologie, European Respiratory Society, Marie Curie Foundation, Else Kröner Fresenius Stiftung, Capnetz Stiftung, International Max Planck Research School, Vaxxilon, Actelion, Bayer Health Care, Biotest, Boehringer Ingelheim. He received consulting fees from Noxxon, Pantherna, Vaxxilon, Aptarion, Glaxo Smith Kline, Sinoxa, Biotest, Thieme, and received honoraria for presentations from Astra Zeneca, Berlin Chemie, Chiesi, Novartis, Actelion, Boehringer Ingelheim, Glaxo Smith Kline, Biotest, Bayer Health Care. He has issued several patents.
Dr. Vehreschild reports to have received honoraria for presentations from Merck / MSD, Gilead, Pfizer, Astellas Pharma, Basilea, German Centre for Infection Research (DZIF), University Hospital Freiburg/ Congress and Communication, Academy for Infectious Medicine, University Manchester, German Society for Infectious Diseases (DGI), Ärztekammer Nordrhein, University Hospital Aachen, Back Bay Strategies, German Society for Internal Medicine (DGIM), Shionogi, Molecular Health, Netzwerk Universitätsmedizin, Janssen, NordForsk. He received research funding from Merck / MSD, Gilead, Pfizer, Astellas Pharma, Basilea, German Centre for Infection Research (DZIF), German Federal Ministry of Education and Research (BMBF), (PJ-T: DLR), University of Bristol, Rigshospitalet Copenhagen
All other authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript, except for the Network University Medicine.
Availability of data and material
Data is available under the regulations of NAPKON’s Use & Access process regulations (https://proskive.napkon.de).
Code availability
The code of the analysis or NAPKON Suite portal is available from corresponding author upon reasonable request.
Ethics approval
NAPKON’s study protocols have been approved at institutional review boards / ethics committees of all participating study sites.
Consent to participate
Informed consent was obtained from all individual participants included in the study.
Consent for publication
No identifying information is included in this article.
Acknowledgements
The National Pandemic Cohort Network (NAPKON) was supported by the German Federal Ministry of Education and Research (BMBF) via the Network University Medicine (NUM) (FKZ: 01KX2021).
We express our gratitude to all study teams that supported the NAPKON study:
Agaplesion Bethesda Krankenhaus Bergedorf gemeinnützige GmbH (Marc Gregor Bota), Elisabeth-Krankenhaus Essen (Ingo Voigt), Frankfurt Universitätsklinikum (Maria J.G.T. Vehreschild, Jörg J. Vehreschild), Hausarztpraxis Dashti (Hiwa Dashti), Hausarztpraxis Egestorf, Bispingen (Barbara Laumerich), Helios Klinik Bad Saarow (Oliver Pociuli), Helios Klinikum Duisburg (Nikolaus Büchner), Helios Klinikum Erfurt (Sabine Adler), Helios Klinikum Krefeld (Mathias Lehmann), Helios Klinikum Siegburg (Selcuk Tasci), Kinder- und Jugendpraxis Jorczyk, Dresden (Maximilian Jorczyk), KJF Klinik Josefinum gGmbH (Thomas Keller), Klinik Hallerwiese-Cnopfsche Kinderklinik (Michael Schroth), Klinikum Dortmund gGmbH, Medizinische Klinik Nord (Martin Hower), Klinikum Leverkusen (Lukas Eberwein), Klinikum Worms (Tim Zimmermann), Krankenhaus Bethanien - Institut für Pneumologie an der Universität zu Köln (Simon-Dominik Herkenrath), Malteser Krankenhaus St. Franziskus-Hospital (SFH) Flensburg (Milena Milovanovic), MVZ am Isartor, München (Ramona Pauli), MVZ im Altstadt-Caree Fulda GmbH Medizinisches Versorgungszentrum (Jörg Simon), OWL: Evangelisches Klinikum Bethel (Eckard Hamelmann), OWL: Klinikum Bielefeld (Christoph Stellbrink), OWL: Klinikum Lippe (Johannes-Josef Tebbe), Petrus Krankenhaus Wuppertal (Sven Stieglitz), Praxis am Ebertplatz (Christoph Wyen), Praxis Bosch und Renner, Köln (Jan Bosch), Praxis Dilltal, Burbach (Mirko Steinmüller), Praxis Dr. Allerlei, Frankfurt am Main (Christoph Allerlei), Praxis Dr. Böbel, Reutlingen (Markus Böbel), Praxis Dr. Elke Heinitz, Grube (Elke Natascha Heinitz), Praxis Dr. med Ariane Roecken (Ariane Roecken), Praxis Dr. med. Andrea Münkle-Krimly (Andrea Münckle-Krimly), Praxis Dr. med. Christiane Guderian (Christiane Guderian), Praxis im Tennental (Ingmar Silberbaur), SHG-Kliniken Völklingen (Harald Schäfer), Tropenklinik Paul-Lechler-Krankenhaus Tübingen (Claudia Raichle), TUM München (Christoph Spinner), UKGM Standort Marburg (Bernd Schmeck ), Uniklinik Carl Gustav Carus Dresden (Heidi Altmann, Nicole Toepfner), Uniklinik der Ruhr-Universität Bochum (Wolfgang Schmidt), Uniklinik Düsseldorf (Björn Jensen), Uniklinik Erlangen (Andreas Kremer), Uniklinik Göttingen (Sabine Blaschke), Uniklinik Halle (Jochen Dutzmann), Uniklinik Hamburg-Eppendorf (Marylyn Addo), Uniklinik Homburg (Robert Bals), Uniklinik Leipzig (Sven Bercker), Uniklinik Münster (Phil-Robin Tepasse), Uniklinik Regensburg (Frank Hanses), Uniklinik RWTH Aachen (Dirk Müller-Wieland), Uniklinik Schleswig-Holstein, Kiel (Anette Friedrichs), Uniklinik Schleswig-Holstein, Lübeck (Jan Rupp), Uniklinik Tübingen (Siri Göpel), Uniklinik Würzburg (Jens Maschmann), Universitätsklinikum Augsburg (Christine Dhillon), Universitätsklinikum Bonn (Jacob Nattermann), Universitätsklinikum Essen (Ingo Voigt), Universitätsklinikum Magdeburg (Wilfred Obst), Universitätsmedizin der Johannes Gutenberg-Universität Mainz (Martin Franz Sprinzl), Universitätsmedizin Greifswald (Christian Scheer), Universitätsmedizin Mannheim (Andreas Teufel), Universitätsmedizin Oldenburg (Ulf Günther), Charité - Universitätsmedizin Berlin (Martin Witzenrath, Thomas Keil, Thomas Zoller, Sein Schmidt, Michael Hummel, Lilian Krist, Julia Fricke, Maria Rönnefarth, Denise Treue, Ludie Kretzler, Chantip Dang-Heine, Paul Triller, Andreas Jooß, Jenny Schlesinger, Natalja Liseweski, Christina Pley, Carmen Scheibenbogen), Hannover Medizinische Hochschule (Marius Hoeper), Jena (Philipp A. Reuken), Klinikum der Universität München (Michael von Bergwelt), UKSH-Kiel (Rainer Noth), UKSH-Lübeck (Daniel Drömann), Universitätsklinikum Frankfurt (Maria J.G.T. Vehreschild), Universitätsklinikum Freiburg (Siegbert Rieg), Universitätsklinikum Giessen / Marburg (Istvan Vadasz), Universitätsklinikum Köln (Philipp A. Koehler), Universtitästklinikum Heidelberg (Uta Merle), Kiel Universitätsklinikum (Stefan Schreiber), Würzburg Universitätsklinikum (Peter Heuschmann, Stefan Störk)
The following individuals have supported governance bodies of the NAPKON:
Use & Access Committee: Anette Friedrichs, Astrid Petersmann, Claudia Ellert, Georg Schmidt, Janne Vehreschild, Katrin Milger, Marie von Lilienfeld, Martin Witzenrath, Oliver Witzke, Patrick Meybohm, Peter Heuschmann, Sabine Blaschke, Sandra Frank, Stefan Schreiber, Thomas Illig
Advisory Board: Alexander Hein, Andrea Wittig, Andreas Simm, Anette Friedrichs, Anke Reinacher-Schick, Anna Frey, Antonella Iannaccone, Astrid Petersmann, Benjamin Maasoumy, Benjamin Waschki, Bimba Hoyer, Brigitt van Oorschot, Carolina van Schaik, Christina Lemhöfer, Christina Polidori, Christine Klein, Daniel Medenwald, Eva Christina Schulte, Eva Grill, Felix Meinel, Folke Brinkmann, Ghazal Arabi, Heike Bickeböller, Holger Lindner, Ildiko Gagyor, Jessica Hassel, Jürgen Deckert, Katrin Milger-Kneidinger, Kerstin Ludwig, Marcus Dörr, Marie von Lilienfeld-Toal, Martin Möckel, Martin Weigl, Matthias Nauck, Miriam Banas, Muenevver Demir, Nicole Lindenberg, Nora Hettich, Norma Jung, Oliver Witzke, Orlando Guntinas-Lichius, Patrick Meybohm, Reinhard Berner, Sabine Blaschke, Samuel Knauss, Sandra Frank, Sebastian Baumeister, Sebastian Dolff, Selma Ugurel, Sophia Stöcklein, Stefanie Joos, Winfred Häuser
The coordination and infrastructure of the NAPKON was conducted by:
ICU: Jörg Janne Vehreschild, Maximilian Schons, Sina Hopff, Markus Brechtel, Cristina Schmidt-Ibanez, Johannes Schneider, Carolin Jakob, Franziska Voß
BCU: Inga Bernemann, Sonja Kunze, Maike Tauchert, Thomas Illig, Gabriele Anton
ECU: Cornelia Fiessler, Mirjam Kohls, Olga Miljukov, Steffi Jiru-Hillmann, Jens-Peter Reese, Peter Heuschmann
IGCU: Jens-Peter Reese, Peter Heuschmann, Anna-Lena Hofmann, Julia Schmidt, Kathrin Ungethüm, Anna Horn, Michael Krawczak
SUEP: Jörg Janne Vehreschild, Melanie Stecher, Lisa Pilgram, Clara Brünn, Ramsia Geisler, Margarete Scherer, Kristina Seibel, Marina Hagen
POP: Thomas Bahmer, Wolfgang Lieb, Daniel Pape, Stefan Schreiber, Anne Hermes, Irene Lehmann, Corina Maetzler, Lukas Tittmann
HAP: Lena Johanna Lippert, Sein Schmidt, Fridolin Steinbeis, Martin Witzenrath, Florian Kurth, Charlotte Thibeault
DZHK: Roberto Lorbeer, Bettina Lorenz-Depiereux, Monika Kraus, Christian Schäfer, Jens Schaller, Mario Schattschneider, Dana Stahl, Heike Valentin, Dagmar Krefting, Matthias Nauck
Pediatric core unit: Nicole Töpfner, Reinhard Berner
GECCO & Interoperability Team: Christof von Kalle, Silvia Thun, Alexander Bartschke, Stefanie Rudolph, Julian Sass
Kardiology team: Eike Nagel, Valentina Püntmann. We acknowledge the dedicated support of clinical research support staff of the Institute of Experimental and Translational Cardiovascular Imaging, including Tammy Wolf, Thourier Azdad, Franziska Weis, Ira Krückemeier, Simon Bohlender, MSc, Deniz Desik, BA, and Layla Laghchioua, MSc.
Coordination NUM: Ralf Heyder, Silke Wiedmann