This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Systolic Blood Pressure is Positively Correlated With Headache Frequency: A 3-Month Follow-Up Study on 441 Migraine Patients
Shuu-Jiun Wang
Taipei Veterans General Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0001-5179-5358
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background Whether blood pressure (BP) per secorrelateswith headache frequencyinmigraineis uncertain.
Methods Newly diagnosed migrainepatients withoutanti-hypertensive or migraine preventive treatmentwere prospectively enrolled.Standardized BPmeasurementwas doneat each visit. Patientswere dichotomized bythe overall arithmetic mean of baseline systolic BPs (SBPs).Correlationsbetween baseline SBPs and monthly headache days (MHDs),based on prospective headache diaries,weredetermined.Participants were treated as usualfor 3 months. The associationsbetweenchanges (Δ) inBP andin MHDat 3 monthswere examined.
Results In total, 441 (344F/97M, mean age 39.1±10.3 years) migraine patients were analyzed, including 197 (44.7%) with above-average SBPs, i.e. ≥120.1 mmHg. There were significant correlations between SBPs and MHDs at baseline (Spearman’s rho=0.181, p=0.012) and between ΔSBPs and ΔMHDs at3months (Spearman’s rho=0.257, p<0.001) in patients with above-average SBPs. In addition, a≥50% MHD improvement increased the odds for5-mmHgSBP reductionsat 3 months(odds ratio=1.70, 95% confidence interval=1.05-2.76, p=0.032).
Conclusions SBP was associated with headache frequency in migraine patients and the association was stronger in those with higher SBP. The improvement in headache frequency paralleled that in SBP, although the underlying mechanisms remain to be determined.
Keywords
Migraine, blood pressure, headache frequency, preventive treatment, prognosis
Figure 1
Figure 2
Due to technical limitations, full-text HTML conversion of this manuscript could not be completed. However, the manuscript can be downloaded and accessed as a PDF.
Due to technical limitations, table 1, table 2 and table 3 is only available as a download in the Supplemental Files section.
This is a list of supplementary files associated with this preprint. Click to download.
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 15 Dec, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Neurology
Learn more about our company.
This is a preprint. It has not completed peer review.
Research article
Systolic Blood Pressure is Positively Correlated With Headache Frequency: A 3-Month Follow-Up Study on 441 Migraine Patients
Shuu-Jiun Wang
Taipei Veterans General Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0001-5179-5358
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 15 Dec, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Neurology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background Whether blood pressure (BP) per secorrelateswith headache frequencyinmigraineis uncertain.
Methods Newly diagnosed migrainepatients withoutanti-hypertensive or migraine preventive treatmentwere prospectively enrolled.Standardized BPmeasurementwas doneat each visit. Patientswere dichotomized bythe overall arithmetic mean of baseline systolic BPs (SBPs).Correlationsbetween baseline SBPs and monthly headache days (MHDs),based on prospective headache diaries,weredetermined.Participants were treated as usualfor 3 months. The associationsbetweenchanges (Δ) inBP andin MHDat 3 monthswere examined.
Results In total, 441 (344F/97M, mean age 39.1±10.3 years) migraine patients were analyzed, including 197 (44.7%) with above-average SBPs, i.e. ≥120.1 mmHg. There were significant correlations between SBPs and MHDs at baseline (Spearman’s rho=0.181, p=0.012) and between ΔSBPs and ΔMHDs at3months (Spearman’s rho=0.257, p<0.001) in patients with above-average SBPs. In addition, a≥50% MHD improvement increased the odds for5-mmHgSBP reductionsat 3 months(odds ratio=1.70, 95% confidence interval=1.05-2.76, p=0.032).
Conclusions SBP was associated with headache frequency in migraine patients and the association was stronger in those with higher SBP. The improvement in headache frequency paralleled that in SBP, although the underlying mechanisms remain to be determined.
Figure 1
Figure 2
Due to technical limitations, full-text HTML conversion of this manuscript could not be completed. However, the manuscript can be downloaded and accessed as a PDF.
Due to technical limitations, table 1, table 2 and table 3 is only available as a download in the Supplemental Files section.