Acknowledgments:
The authors thank the Clinical investigation Center of the hospital Européen Georges-Pompidou, AP-HP for their collaboration in this work.
Fundings:
This work was supported by a joint grant from the Assistance Publique des Hôpitaux de Paris (Contrat de Recherche Clinique grant no. CRC06043), the INSERM-DGOS (Contrat de Recherche Translationnelle), the Agence Nationale pour la Recherche Physique et Chimie du Vivant, the Ministère de l’Enseignement Supérieur et de la Recherche, the Université de Paris, the Centre National de la Recherche Scientifique (CNRS), the Institut National de la Santé et de la Recherche Médicale (INSERM), the Centre de Recherche des Cordeliers and the ligue nationale contre le cancer (LNCC, Program “Equipe labelisée LIGUE”; no. EL2016.LNCC). Geoffroy Poulet was supported by a CIFRE (N°2018/0368) funding from ANRT (Association Nationale Recherche Technologie) and Eurofins-Biomnis.
Author contributions:
The individual contributions for this work are:
GP: Experimental work and analysis; Data acquision; Writing - Original Draft; Writing - Review & Editing
JSH: Data acquision; Formal analysis; Investigation; Methodology; Resources; Data Curation; Writing - Original Draft; Writing - Review & Editing; Funding acquisition
AB: Formal analysis; Investigation; Methodology; Resources; Data Curation; Writing - Review & Editing
DB: Data acquision; Investigation; Methodology; Resources; Data Curation; Writing - Review & Editing
WX: Data interpretation; Writing - Review & Editing
FG: Data acquision; Experimental work and analysis; Writing - Review & Editing
AB: Data acquision; Experimental work and analysis; Writing - Review & Editing
GB: Experimental work and analysis; Writing - Original Draft; Writing - Review & Editing
VG: Supervision; Writing - Review & Editing
LP: Supervision; Writing - Review & Editing
MA : Investigation ; Resources ; Supervision; Funding acquisition; Writing - Review & Editing;
PLP : Conceptualization ; Methodology ; Investigation ; Resources ; Supervision;
LB : Formal analysis; Data Curation ; Writing - Original Draft; Writing - Review & Editing
VT : Conceptualization; Methodology; Resources; Data Curation ; Writing - Original Draft; Writing - Review & Editing; Visualization; Supervision; Funding acquisition
All authors reviewed the manuscript.
Data availability statement
The data that support the findings of this study are available from the corresponding authors VT or LB, upon reasonable request.
Competing interests’ statements:
VT: Honoraria from Raindance Technologies and Boerhinger Ingehleim; cofounder emulseo; board emulseo
PLP: Honoraria and board: Amgen, Merck-Serono, Boehringer Ingelheim, Sanofi, Roche, Lilly
AB: Honoraria and board: Amgen
JSH : speaker, advisory board or consultancy fees from Amgen, Astra Zeneca, Bayer, Bristol-Myers Squibb, Novartis, Novo Nordisk, Vifor Pharma, all unrelated to the present work
GP: Eurofins-Biomnis employee
PL: Eurofins-Biomnis employee
VG: Eurofins-Biomnis employee
AB (Dr Audrey Boutonnet): ADELIS employee
FG: ADELIS employee
The other authors declare no potential conflicts of interest.