Impact of Age for Overall Survival in Head and Neck Sarcoma
Background:The association between age and survival outcomes in head and neck sarcoma (HNS) has yet to be fully investigated due to rare tumor. To research the association between age at surgery and survival outcomes of patients with HNS.
Methods: Twenty-six patients with HNS who underwent by surgery from 2003 to 2017 were retrospectively enrolled. The association between clinicopathological parameters and age was assessed by Mann-Whitney U test, and the optimal cut-off age at surgery for predicting death was determined by receiver operating curve analysis. Log-rank test and Cox proportional hazards model were used for survival analyses.
Results: Patients who did not undergo chemotherapy were significantly older age at surgery. Fifty-five was the cut-off age that predicted death. Shorter survival rates of overall, disease-specific, local recurrence-free and disease-free were associated with older age. Age (≥ 55 years/< 55 years) was correlated with shorter overall survival by multivariate analysis adjusting with chemotherapy (absence/presence).
Conclusion: Older age predicts worse overall survival in HNS.
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Posted 16 Dec, 2020
Received 16 Jan, 2021
On 10 Jan, 2021
On 09 Jan, 2021
On 01 Jan, 2021
Invitations sent on 27 Dec, 2020
On 14 Dec, 2020
On 14 Dec, 2020
On 13 Dec, 2020
On 08 Dec, 2020
Impact of Age for Overall Survival in Head and Neck Sarcoma
Posted 16 Dec, 2020
Received 16 Jan, 2021
On 10 Jan, 2021
On 09 Jan, 2021
On 01 Jan, 2021
Invitations sent on 27 Dec, 2020
On 14 Dec, 2020
On 14 Dec, 2020
On 13 Dec, 2020
On 08 Dec, 2020
Background:The association between age and survival outcomes in head and neck sarcoma (HNS) has yet to be fully investigated due to rare tumor. To research the association between age at surgery and survival outcomes of patients with HNS.
Methods: Twenty-six patients with HNS who underwent by surgery from 2003 to 2017 were retrospectively enrolled. The association between clinicopathological parameters and age was assessed by Mann-Whitney U test, and the optimal cut-off age at surgery for predicting death was determined by receiver operating curve analysis. Log-rank test and Cox proportional hazards model were used for survival analyses.
Results: Patients who did not undergo chemotherapy were significantly older age at surgery. Fifty-five was the cut-off age that predicted death. Shorter survival rates of overall, disease-specific, local recurrence-free and disease-free were associated with older age. Age (≥ 55 years/< 55 years) was correlated with shorter overall survival by multivariate analysis adjusting with chemotherapy (absence/presence).
Conclusion: Older age predicts worse overall survival in HNS.
Figure 1
Figure 1
Figure 2
Figure 2
Figure 2
Figure 2