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Impact of Age for Overall Survival in Head and Neck Sarcoma
Hidenori Suzuki
Aichi Cancer Center Hospital
Corresponding Author
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Background：The association between age and survival outcomes in head and neck sarcoma (HNS) has yet to be fully investigated due to rare tumor. To research the association between age at surgery and survival outcomes of patients with HNS.
Methods: Twenty-six patients with HNS who underwent by surgery from 2003 to 2017 were retrospectively enrolled. The association between clinicopathological parameters and age was assessed by Mann-Whitney U test, and the optimal cut-off age at surgery for predicting death was determined by receiver operating curve analysis. Log-rank test and Cox proportional hazards model were used for survival analyses.
Results: Patients who did not undergo chemotherapy were significantly older age at surgery. Fifty-five was the cut-off age that predicted death. Shorter survival rates of overall, disease-specific, local recurrence-free and disease-free were associated with older age. Age (≥ 55 years/< 55 years) was correlated with shorter overall survival by multivariate analysis adjusting with chemotherapy (absence/presence).
Conclusion: Older age predicts worse overall survival in HNS.
Keywords
Head and neck sarcoma, Overall survival, Age, Predictor, Chemotherapy
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CURRENT STATUS: Under Review
Version 1
Posted 16 Dec, 2020
No community comments so far
Review #1 received
Received 16 Jan, 2021
Reviewer #3 agreed
On 10 Jan, 2021
Reviewer #2 agreed
On 09 Jan, 2021
Reviewer #1 agreed
On 01 Jan, 2021
Reviewers invited
Invitations sent on 27 Dec, 2020
Editor assigned
On 14 Dec, 2020
Editor invited
On 14 Dec, 2020
Submission checks complete
On 13 Dec, 2020
First submitted
On 08 Dec, 2020
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This preprint is under consideration at World Journal of Surgical Oncology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Impact of Age for Overall Survival in Head and Neck Sarcoma
Hidenori Suzuki
Aichi Cancer Center Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 16 Dec, 2020
No community comments so far
Review #1 received
Received 16 Jan, 2021
Reviewer #3 agreed
On 10 Jan, 2021
Reviewer #2 agreed
On 09 Jan, 2021
Reviewer #1 agreed
On 01 Jan, 2021
Reviewers invited
Invitations sent on 27 Dec, 2020
Editor assigned
On 14 Dec, 2020
Editor invited
On 14 Dec, 2020
Submission checks complete
On 13 Dec, 2020
First submitted
On 08 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background：The association between age and survival outcomes in head and neck sarcoma (HNS) has yet to be fully investigated due to rare tumor. To research the association between age at surgery and survival outcomes of patients with HNS.
Methods: Twenty-six patients with HNS who underwent by surgery from 2003 to 2017 were retrospectively enrolled. The association between clinicopathological parameters and age was assessed by Mann-Whitney U test, and the optimal cut-off age at surgery for predicting death was determined by receiver operating curve analysis. Log-rank test and Cox proportional hazards model were used for survival analyses.
Results: Patients who did not undergo chemotherapy were significantly older age at surgery. Fifty-five was the cut-off age that predicted death. Shorter survival rates of overall, disease-specific, local recurrence-free and disease-free were associated with older age. Age (≥ 55 years/< 55 years) was correlated with shorter overall survival by multivariate analysis adjusting with chemotherapy (absence/presence).
Conclusion: Older age predicts worse overall survival in HNS.
Figure 1
Figure 1
Figure 2
Figure 2
Figure 2
Figure 2