TABLE 1. The Top 100 Cited Articles on Bone Metastases
|
Rank
|
Author
|
Title
|
Journal
|
Year
|
Citation
|
Citation No./Year
|
1
|
Kang, Y. B.
|
A multigenic program mediating breast cancer metastasis to bone
|
Cancer Cell
|
2003
|
1707
|
100.41
|
2
|
Roodman, G. D.
|
Mechanisms of disease: mechanisms of bone metastasis
|
New England Journal of Medicine
|
2004
|
1347
|
84.19
|
3
|
Coleman, R. E.
|
Clinical features of metastatic bone disease and risk of skeletal morbidity
|
Clinical Cancer Research
|
2006
|
1122
|
80.14
|
4
|
Patchell, R. A.
|
Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial
|
Lancet
|
2005
|
1115
|
74.33
|
5
|
Fizazi, K.
|
Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study
|
Lancet
|
2011
|
1097
|
121.89
|
6
|
Coleman, R. E
|
Metastatic bone disease: clinical features, pathophysiology and treatment strategies
|
Cancer Treatment Reviews
|
2001
|
1048
|
55.16
|
7
|
Coleman, R. E.
|
Skeletal complications of malignancy
|
Cancer
|
1997
|
1011
|
43.96
|
8
|
Stopeck, A. T.
|
Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study
|
Journal of Clinical Oncology
|
2010
|
839
|
83.90
|
9
|
Saad, F.
|
Long-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostate cancer
|
Journal of the National Cancer Institute
|
2004
|
784
|
49.00
|
10
|
Taichman, R. S.
|
Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone
|
Cancer Research
|
2002
|
761
|
42.28
|
11
|
Coleman, R. E.
|
The clinical course of bone metastases from breast cancer
|
British Journal of Cancer
|
1987
|
755
|
22.88
|
12
|
Hortobagyi, G. N.
|
Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases. Protocol 19 Aredia Breast Cancer Study Group
|
The New England Journal of Medicine
|
1996
|
746
|
31.08
|
13
|
Yin, J. J.
|
TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development
|
Journal of Clinical Investigation
|
1999
|
692
|
32.95
|
14
|
Hillner, B. E.
|
American society of clinical oncology 2003 update on the role of bisphosphonates and bone health issues in women with breast cancer
|
Journal of Clinical Oncology
|
2003
|
688
|
40.47
|
15
|
Tomita, K.
|
Surgical strategy for spinal metastases
|
Spine
|
2001
|
642
|
33.79
|
16
|
Gilbert, R. W.
|
Epidural spinal cord compression from metastatic tumor: diagnosis and treatment
|
Annals of Neurology
|
1978
|
637
|
15.17
|
17
|
Henry, D. H.
|
Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma
|
Journal of Clinical Oncology
|
2011
|
631
|
70.11
|
18
|
Rosen, L. S.
|
Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: A phase III, double-blind, comparative trial
|
Cancer Journal
|
2001
|
618
|
32.53
|
19
|
Cotten, A.
|
Percutaneous vertebroplasty for osteolytic metastases and myeloma: effects of the percentage of lesion filling and the leakage of methyl methacrylate at clinical follow-up
|
Radiology
|
1996
|
615
|
25.63
|
20
|
Rosen, L. S.
|
Long-term efficacy and safety of zoledronic acid compared with pamidronate disodium in the treatment of skeletal complications in patients with advanced multiple myeloma or breast carcinoma - A randomized, double-blind, multicenter, comparative trialarative trial
|
Cancer
|
2003
|
595
|
35.00
|
21
|
Weilbaecher, K. N.
|
Cancer to bone: a fatal attraction
|
Nature Reviews Cancer
|
2011
|
577
|
64.11
|
22
|
Thalmann, G. N.
|
Androgen-independent cancer progression and bone metastasis in the LNCaP model of human prostate cancer
|
Cancer Research
|
1994
|
560
|
21.54
|
23
|
Fleisch, H.
|
Bisphosphonates. Pharmacology and use in the treatment of tumour-induced hypercalcaemic and metastatic bone disease
|
Drugs
|
1991
|
558
|
19.24
|
24
|
Mercadante, S.
|
Malignant bone pain: pathophysiology and treatment
|
Pain
|
1997
|
553
|
24.04
|
25
|
Tong, D.
|
The palliation of symptomatic osseous metastases: final results of the Study by the Radiation Therapy Oncology Group
|
Cancer
|
1982
|
537
|
14.13
|
26
|
Weill, A.
|
Spinal metastases: indications for and results of percutaneous injection of acrylic surgical cement
|
Radiology
|
1996
|
524
|
21.83
|
27
|
Tokuhashi, Y.
|
A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis
|
Spine
|
2005
|
520
|
34.67
|
28
|
Even-Sapir, E.
|
The detection of bone metastases in patients with high-risk prostate cancer: Tc-99m-MDP planar bone scintigraphy, single- and multi-field-of-view SPECT, F-18-fluoride PET, and F-18-fluoride PET/CT
|
Journal of Nuclear Medicine
|
2006
|
518
|
37.00
|
29
|
Jones, D. H.
|
Regulation of cancer cell migration and bone metastasis by RANKL
|
Nature
|
2006
|
500
|
35.71
|
30
|
Chow, E.
|
Palliative radiotherapy trials for bone metastases: A systematic review
|
Journal of Clinical Oncology
|
2007
|
497
|
38.23
|
31
|
Boissier, S.
|
Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases
|
Cancer Research
|
2000
|
482
|
24.10
|
32
|
Rosen, L. S.
|
Zoledronic acid versus placebo in the treatment of skeletal metastases in patients with lung cancer and other solid tumors: A phase III, double-blind, randomized trial - The zoledronic acid lung cancer and other solid tumors study group
|
Journal of Clinical Oncology
|
2003
|
473
|
27.82
|
33
|
Lutz, S.
|
Palliative radiotherapy for bone metastases: an astro evidence-based guideline
|
International Journal of Radiation Oncology Biology Physics
|
2011
|
473
|
52.56
|
34
|
Lipton, A.
|
Pamidronate prevents skeletal complications and is effective palliative treatment in women with breast carcinoma and osteolytic bone metastases - Long term follow-up of two randomized, placebo-controlled trials
|
Cancer
|
2000
|
469
|
23.45
|
35
|
Soloway, M. S.
|
Stratification of patients with metastatic prostate cancer based on extent of disease on initial bone scan
|
Cancer
|
1988
|
459
|
14.34
|
36
|
Fourney, D. R.
|
Percutaneous vertebroplasty and kyphoplasty for painful vertebral body fractures in cancer patients
|
Journal of Neurosurgery
|
2003
|
453
|
26.65
|
37
|
Hortobagyi, G. N.
|
Long-term prevention of skeletal complications of metastatic breast cancer with pamidronate. Protocol 19 Aredia Breast Cancer Study Group
|
Journal of Clinical Oncology
|
1998
|
445
|
20.23
|
38
|
Theriault, R. L.
|
Pamidronate reduces skeletal morbidity in women with advanced breast cancer and lytic bone lesions: a randomized, placebo-controlled trial
|
Journal of Clinical Oncology
|
1999
|
439
|
20.90
|
39
|
Hartsell, W. F.
|
Randomized trial of short-versus long-course radiotherapy for palliation of painful bone metastases
|
Jnci-Journal of the National Cancer Institute
|
2005
|
438
|
29.20
|
40
|
Gerszten, P. C.
|
Radiosurgery for spinal metastases - Clinical experience in 500 cases from a single institution
|
Spine
|
2007
|
438
|
33.69
|
41
|
Paterson, A. H.
|
Double-blind controlled trial of oral clodronate in patients with bone metastases from breast cancer
|
Journal of Clinical Oncology
|
1993
|
437
|
16.19
|
42
|
Rosen, L. S.
|
Long-term efficacy and safety of zoledronic acid in the treatment of skeletal metastases in patients with nonsmall cell lung carcinoma and other solid tumors - A randomized, phase III, double-blind, placebo-controlled trial
|
Cancer
|
2004
|
434
|
27.13
|
43
|
Zhang, X. H.
|
Latent bone metastasis in breast cancer tied to src-dependent survival signals
|
Cancer Cell
|
2009
|
424
|
38.55
|
44
|
Mundy, G. R.
|
Mechanisms of bone metastasis
|
Cancer
|
1997
|
413
|
17.96
|
45
|
Steenland, E.
|
The effect of a single fraction compared to multiple fractions on painful bone metastases: a global analysis of the Dutch Bone Metastasis Study
|
Radiotherapy and Oncology
|
1999
|
411
|
19.57
|
46
|
Schlumberger, M.
|
Long-term results of treatment of 283 patients with lung and bone metastases from differentiated thyroid carcinoma
|
The Journal of Clinical Endocrinology and Metabolism
|
1986
|
406
|
11.94
|
47
|
Brown, J. E.
|
Bone turnover markers as predictors of skeletal complications in prostate cancer, lung cancer, and other solid tumors
|
Jnci-Journal of the National Cancer Institute
|
2005
|
392
|
26.13
|
48
|
Coleman, R. E.
|
Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid
|
Journal of Clinical Oncology
|
2005
|
379
|
25.27
|
49
|
Kang, Y. B.
|
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway
|
Proceedings of the National Academy of Sciences of the United States of America
|
2005
|
370
|
24.67
|
50
|
Tokuhashi, Y.
|
Scoring system for the preoperative evaluation of metastatic spine tumor prognosis
|
Spine
|
1990
|
367
|
12.23
|
51
|
Cook, G. J.
|
Detection of bone metastases in breast cancer by 18FDG PET: differing metabolic activity in osteoblastic and osteolytic lesions
|
Journal of Clinical Oncology
|
1998
|
361
|
16.41
|
52
|
Fizazi, K.
|
Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates
|
Journal of Clinical Oncology
|
2009
|
359
|
32.64
|
53
|
Berenson, J. R.
|
Zoledronic acid reduces skeletal-related events in patients with osteolytic metastases. A double-blind, randomized dose-response study
|
Cancer
|
2001
|
353
|
18.58
|
54
|
Goetz, M. P.
|
Percutaneous image-guided radiofrequency ablation of painful metastases involving bone: a multicenter study
|
Journal of Clinical Oncology
|
2004
|
352
|
22.00
|
55
|
Logothetis, C. J.
|
Osteoblasts in prostate cancer metastasis to bone
|
Nature Reviews Cancer
|
2005
|
352
|
23.47
|
56
|
Wu, J. S. Y.
|
Meta-analysis of dose-fractionation radiotherapy trials for the palliation of painful bone metastases
|
International Journal of Radiation Oncology Biology Physics
|
2003
|
350
|
20.59
|
57
|
Nielsen, O. S.
|
Bone metastases: pathophysiology and management policy
|
Journal of Clinical Oncology
|
1991
|
349
|
12.03
|
58
|
Saad, F.
|
Pathologic fractures correlate with reduced survival in patients with malignant bone disease
|
Cancer
|
2007
|
346
|
26.62
|
59
|
Sasaki, A.
|
Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice
|
Cancer research
|
1995
|
344
|
13.76
|
60
|
Kohno, N.
|
Zoledronic acid significantly reduces skeletal complications compared with placebo in Japanese women with bone metastases from breast cancer: A randomized, placebo-controlled trial
|
Journal of Clinical Oncology
|
2005
|
343
|
22.87
|
61
|
Body, J. J.
|
A study of the biological receptor activator of nuclear factor-kappa B ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer
|
Clinical Cancer Research
|
2006
|
341
|
24.36
|
62
|
Nilsson, S.
|
Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: a randomised, multicentre, placebo-controlled phase II study
|
Lancet Oncology
|
2007
|
339
|
26.08
|
63
|
Young, R. F.
|
Treatment of spinal epidural metastases. Randomized prospective comparison of laminectomy and radiotherapy
|
Journal of neurosurgery
|
1980
|
339
|
8.48
|
64
|
Fisher, C. G.
|
A novel classification system for spinal instability in neoplastic disease an evidence-based approach and expert consensus from the Spine Oncology Study Group
|
Spine
|
2010
|
337
|
33.70
|
65
|
Schlumberger, M.
|
Radioactive iodine treatment and external radiotherapy for lung and bone metastases from thyroid carcinoma
|
Journal of Nuclear Medicine
|
1996
|
336
|
14.00
|
66
|
Hamaoka, T.
|
Bone imaging in metastatic breast cancer
|
Journal of Clinical Oncology
|
2004
|
336
|
21.00
|
67
|
Price, P.
|
Prospective randomised trial of single and multifraction radiotherapy schedules in the treatment of painful bony metastases
|
Radiotherapy and Oncology
|
1986
|
333
|
9.79
|
68
|
Saad, F.
|
Incidence, risk factors, and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases
|
Annals of Oncology
|
2012
|
323
|
40.38
|
69
|
Mirels, H.
|
Metastatic disease in long bones. A proposed scoring system for diagnosing impending pathologic fractures
|
Clinical Orthopaedics and Related Research
|
1989
|
321
|
10.35
|
70
|
Guise, T. A.
|
Basic mechanisms responsible for osteolytic and osteoblastic bone metastases
|
Clinical Cancer Research
|
2006
|
318
|
22.71
|
71
|
Yamada, Y.
|
High-dose, single-fraction image-guided intensity-modulated radiotherapy for metastatic spinal lesions
|
International Journal of Radiation Oncology Biology Physics
|
2008
|
315
|
26.25
|
72
|
Chow, E.
|
Update on the systematic review of palliative radiotherapy trials for bone metastases
|
Clinical Oncology
|
2012
|
312
|
39.00
|
73
|
Barron, K. D.
|
Experiences with metastatic neoplasms involving the spinal cord
|
Neurology
|
1959
|
312
|
5.11
|
74
|
Sethi, N.
|
Tumor-derived jagged1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells
|
Cancer Cell
|
2011
|
310
|
34.44
|
75
|
Body, J. J.
|
Intravenous ibandronate reduces the incidence of skeletal complications in patients with breast cancer and bone metastases
|
Annals of Oncology
|
2003
|
307
|
18.06
|
76
|
Maranzano, E.
|
Effectiveness of radiation therapy without surgery in metastatic spinal cord compression: final results from a prospective trial
|
International Journal of Radiation Oncology, Biology, Physics
|
1995
|
307
|
12.28
|
77
|
Takeshita, F.
|
Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo
|
Proceedings of the National Academy of Sciences of the United States of America
|
2005
|
306
|
20.40
|
78
|
Chang, E. L.
|
Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure
|
Journal of Neurosurgery-Spine
|
2007
|
304
|
23.38
|
79
|
Boucharaba, A.
|
Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer
|
Journal of Clinical Investigation
|
2004
|
300
|
18.75
|
80
|
Wong, D. A.
|
Spinal metastases: the obvious, the occult, and the impostors
|
Spine
|
1990
|
299
|
9.97
|
81
|
Hornberg, E.
|
Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival
|
Plos One
|
2011
|
296
|
32.89
|
82
|
Lipton, A.
|
Superiority of denosumab to zoledronic acid for prevention of skeletal-related events: a combined analysis of 3 pivotal, randomised, phase 3 trials
|
European Journal of Cancer
|
2012
|
290
|
36.25
|
83
|
Serafini, A. N.
|
Palliation of pain associated with metastatic bone cancer using samarium-153 lexidronam: a double-blind placebo-controlled clinical trial
|
Journal of Clinical Oncology
|
1998
|
290
|
13.18
|
84
|
Kingsley, L. A.
|
Molecular biology of bone metastasis
|
Molecular Cancer Therapeutics
|
2007
|
286
|
22.00
|
85
|
Arguello, F.
|
A murine model of experimental metastasis to bone and bone marrow
|
Cancer Research
|
1988
|
286
|
8.94
|
86
|
Gu, Z.
|
Prostate stem cell antigen (PSCA) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancer
|
Oncogene
|
2000
|
281
|
14.05
|
87
|
Constans, J. P.
|
Spinal metastases with neurological manifestations. Review of 600 cases
|
Journal of Neurosurgery
|
1983
|
280
|
7.57
|
88
|
Daldrup-Link, H. E.
|
Whole-body MR imaging for detection of bone metastases in children and young adults: comparison with skeletal scintigraphy and FDG PET
|
American Journal of Roentgenology
|
2001
|
275
|
14.47
|
89
|
Nilsson, S.
|
First clinical experience with alpha-emitting radium-223 in the treatment of skeletal metastases
|
Clinical Cancer Research
|
2005
|
273
|
18.20
|
90
|
Chen, T. L.
|
Pharmacokinetics and pharmacodynamics of zoledronic acid in cancer patients with bone metastases
|
Journal of Clinical Pharmacology
|
2002
|
273
|
15.17
|
91
|
Body, J. J.
|
A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases
|
Cancer
|
2003
|
271
|
15.94
|
92
|
Bendre, M. S.
|
Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease
|
Bone
|
2003
|
270
|
15.88
|
93
|
Deckers, M.
|
The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells
|
Cancer Research
|
2006
|
268
|
19.14
|
94
|
Sartor, O.
|
Effect of radium-223 dichloride on symptomatic skeletal events in patients with castration-resistant prostate cancer and bone metastases: results from a phase 3, double-blind, randomised trial
|
Lancet Oncology
|
2014
|
264
|
44.00
|
95
|
Thalmann, G. N.
|
LNCaP progression model of human prostate cancer: androgen-independence and osseous metastasis
|
Prostate
|
2000
|
263
|
13.15
|
96
|
Galasko, C. S.
|
Mechanisms of bone destruction in the development of skeletal metastases
|
Nature
|
1976
|
262
|
5.95
|
97
|
Murray, L. J.
|
SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model
|
Clinical & Experimental Metastasis
|
2003
|
259
|
15.24
|
98
|
Edelstyn, G. A.
|
The radiological demonstration of osseous metastases. Experimental observations
|
Clinical Radiology
|
1967
|
259
|
4.89
|
99
|
Lelekakis, M.
|
A novel orthotopic model of breast cancer metastasis to bone
|
Clinical & Experimental Metastasis
|
1999
|
257
|
12.24
|
100
|
Jacobs, S. C.
|
Spread of prostatic cancer to bone
|
Urology
|
1983
|
250
|
6.76
|