Bone metastases (BM) represents a common complication of cancer, patients with BM may experience skeletal complications, such as pathological fractures, spinal cord compression, hypercalcemia, and persisting pain. Currently, there are a large number of publications available on this topic. The purpose of this study was to identify and analyze the 100 most-cited publications on BM research.
All databases from the Web of Science were searched in a three-step approach. First, the 100 most-cited BM studies were identified using only one term “bone metastases” to allow for comprehensive keyword identification. Second, ten keywords identified from the results of the first search were used to conduct a second search of the databases to yield a separate list of the top 100 cited BM publications. Finally, the results of the two searches were overlapped and duplicated articles were removed. After overlapping, the top 100 most-cited articles on BM were selected for further analysis of title, authorship, source journal, publication year, geographic origin, research institution, number of citations, and subspecialty.
The 100 most-cited articles were published from 1959 to 2014 in 44 different journals and were cited from 250 to 1707 times. The most influential period was from 2001–2010, which produced 50 out of the top 100 publications. A total of 12 countries contributed to the 100 articles, and the United States topped the list with 48 articles. The majority of publications were in Journal of Clinical Oncology, which published 16 articles. In terms of institutional support, a total of 13 institutions each supported at least 2 articles, and the first ranked institution was University of Texas M. D. Anderson Cancer Center (USA) with 8 articles. Regarding subspecialty of the studies, the most frequent studies were “clinical description” with 30 articles, followed by “clinical trial” with 20 articles.
In this comprehensive review, we identified and analyzed the 100-most-cited articles on BM research by measuring their citation number, and recognized some of the most important contributions by authors, institutions and countries. Furthermore, our study will help researchers and orthopedic surgeons understand the research trends for BM and as an efficient guide for future BM-related research.