The aim of our study was to detect subclinical abnormalities in carbohydrate metabolism in patients with polycystic ovary syndrome.
Cross-sectional study including 20 patients with PCOS diagnosed according to 5- the Rotterdam criteria. All the patients had normal carbohydrate tolerance (fasting blood 6- glucose<5.6 mmol/l, 2-h plasma glucose after a 75-g oral glucose tolerance test<7.8 mmol/l andglycated hemoglobin <5.8%). For each patient, we performed a continuous glucose monitoring over 72h, measuring the interstitial glucose every 5 minutes (288 measurements per day). We collected data about: the mean blood glucose, obtained by determining the mean values of the 288 measurements made by 24h - the mean amplitude of glycemic excursions, which is the difference between the maximum and minimum glycemic values - the time (in hours) in which the blood glucose was <0.7 g/l and / or>1.4 g/l.
The mean blood glucose (over 72h) was 0.94±0.07 g/l (0.81-1.11).The mean amplitude of glycemic excursions (over 72h) was 0.81 ± 0.23 g/l (0.47-1.31).Fourteen patients (pathologic group) had subclinical glycemic abnormalities: 14 patients had glycemic values<0.7 g/l and 5 patients had also glycemic values>1.4 g/l. The mean amplitude of glycemic excursions was significantly lower (p=0.016) in the normal group (6 patients, 0.64 g/l) compared to the pathologic group(14 patients, 0.88 g/l).The other clinical and biological parameters were comparable between the two groups.
Our findings confirm the high frequency of subclinical abnormalities of carbohydrate metabolism in patients with polycystic ovary syndrome. A regular follow-up of these patients is necessary.