This preprint is under consideration at BMC Geriatrics. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Risk factors of preoperative frailty in elderly inpatients with gastrointestinal cancer
Shihui Yu
First Affiliated Hospital of Anhui Medical University
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Frailty is emerging as an important determinant for health, while researches in the field of frailty start at a later stage in China and mainly focuses on community elderly dwellers. Little is known about frailty in cancer patients in China, nor the risk factors of frailty. This study aimed to investigate the prevalence of frailty and its risk factors in elderly inpatients with gastrointestinal cancer.
Methods
This cross-sectional study was performed at a tertiary hospital in China from Mar. 2020 to Nov. 2020. The study enrolled 265 inpatients aged 60 and older with gastrointestinal cancer who successfully underwent surgery. The demographic and clinical characteristics, biochemical laboratory parameters, and anthropometric data were collected from all patients. The Groningen Frailty Indicator was applied to assess patients’ frailty status. Multivariate logistic regression model analysis was carried out to identify risk factors of frailty and estimate their 95% confidence intervals.
Results
The prevalence of frailty in elderly inpatients with gastrointestinal cancer was 43.8%. A multivariate logistic regression analysis showed that older age (OR = 1.065, 95% CI: 1.001–1.132, P = 0.045), low handgrip strength (OR = 4.346, 95% CI: 1.739–10.863, P = 0.002), no regular exercise habit (OR = 3.228, 95% CI: 1.230–8.469, P = 0.017), and low MNA-SF score (OR = 11.090, 95% CI: 5.119–24.024, P < 0.001) were risk factors of frailty.
Conclusions
This study suggested that the prevalence of frailty was high among elderly inpatients with gastrointestinal cancer. Older age, low handgrip strength, no regular exercise habit, and low MNA-SF score were risk factors of frailty.
Keywords
Frailty, Geriatric assessment, Risk factors, Gastrointestinal cancer, Groningen Frailty Indicator
Figure 1
Figure 2
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 28 Dec, 2020
No community comments so far
Reviewer #2 agreed
On 17 Jan, 2021
Reviewer #1 agreed
On 17 Jan, 2021
Reviewers invited
Invitations sent on 31 Dec, 2020
Editor assigned
On 26 Dec, 2020
Editor invited
On 22 Dec, 2020
Submission checks complete
On 22 Dec, 2020
First submitted
On 19 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Geriatrics & Gerontology
Learn more about our company.
This preprint is under consideration at BMC Geriatrics. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Risk factors of preoperative frailty in elderly inpatients with gastrointestinal cancer
Shihui Yu
First Affiliated Hospital of Anhui Medical University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 28 Dec, 2020
No community comments so far
Reviewer #2 agreed
On 17 Jan, 2021
Reviewer #1 agreed
On 17 Jan, 2021
Reviewers invited
Invitations sent on 31 Dec, 2020
Editor assigned
On 26 Dec, 2020
Editor invited
On 22 Dec, 2020
Submission checks complete
On 22 Dec, 2020
First submitted
On 19 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Geriatrics & Gerontology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Frailty is emerging as an important determinant for health, while researches in the field of frailty start at a later stage in China and mainly focuses on community elderly dwellers. Little is known about frailty in cancer patients in China, nor the risk factors of frailty. This study aimed to investigate the prevalence of frailty and its risk factors in elderly inpatients with gastrointestinal cancer.
Methods
This cross-sectional study was performed at a tertiary hospital in China from Mar. 2020 to Nov. 2020. The study enrolled 265 inpatients aged 60 and older with gastrointestinal cancer who successfully underwent surgery. The demographic and clinical characteristics, biochemical laboratory parameters, and anthropometric data were collected from all patients. The Groningen Frailty Indicator was applied to assess patients’ frailty status. Multivariate logistic regression model analysis was carried out to identify risk factors of frailty and estimate their 95% confidence intervals.
Results
The prevalence of frailty in elderly inpatients with gastrointestinal cancer was 43.8%. A multivariate logistic regression analysis showed that older age (OR = 1.065, 95% CI: 1.001–1.132, P = 0.045), low handgrip strength (OR = 4.346, 95% CI: 1.739–10.863, P = 0.002), no regular exercise habit (OR = 3.228, 95% CI: 1.230–8.469, P = 0.017), and low MNA-SF score (OR = 11.090, 95% CI: 5.119–24.024, P < 0.001) were risk factors of frailty.
Conclusions
This study suggested that the prevalence of frailty was high among elderly inpatients with gastrointestinal cancer. Older age, low handgrip strength, no regular exercise habit, and low MNA-SF score were risk factors of frailty.
Figure 1
Figure 2