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Research Article
Sensory Block Level Prediction of Spinal Anaesthesia With 0.5% Hyperbaric Bupivacaine: A Retrospective Study
Kuang-Yi Chang
Taipei Veterans General Hospital
Corresponding Author
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There is still no consensus on how to determine the dose of spinal anaesthesia with adequate sensory block for a planned surgery. This retrospective study aimed to explore the associations of miscellaneous factors with peak sensory block level after spinal anaesthesia with hyperbaric bupivacaine, and to construct a predictive model for single-shot spinal anaesthesia. We collected the records of 401 non-pregnant adults who underwent spinal anaesthesia with 0.5% hyperbaric bupivacaine at the L3-4 or L4-5 intervertebral space for lower body surgeries. Multiple linear regression analysis was used to investigate predictors of the block level and build up the predictive model. Five variables were identified as independent predictors of the peak sensory block level, including bupivacaine dose, height, weight, gender and age. The predictive model for peak block level after spinal anaesthesia could be expressed as a formula with these five variables and the estimated predictive power was 0.72. Based on this model, it is possible to determine a reasonable dose of hyperbaric bupivacaine for spinal anaesthesia, which gives adequate sensory block required for diverse surgical procedures in various patients and could be considered as a dose reference for sensory block height in spinal anaesthesia.
Keywords
spinal anaesthesia, hyperbaric bupivacaine, multiple linear regression analysis, sensory block level
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CURRENT STATUS: Under Review
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Posted 28 Dec, 2020
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Review #11 received
Received 12 Jan, 2021
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Received 12 Jan, 2021
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Received 12 Jan, 2021
Reviewer #12 agreed
On 12 Jan, 2021
Reviewer #13 agreed
On 12 Jan, 2021
Reviewer #11 agreed
On 12 Jan, 2021
Reviewer #1 agreed
On 12 Jan, 2021
Reviewer #2 agreed
On 12 Jan, 2021
Reviewers invited
Invitations sent on 06 Jan, 2021
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On 22 Dec, 2020
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This preprint is under consideration at Scientific Reports. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Sensory Block Level Prediction of Spinal Anaesthesia With 0.5% Hyperbaric Bupivacaine: A Retrospective Study
Kuang-Yi Chang
Taipei Veterans General Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 28 Dec, 2020
No community comments so far
Review #11 received
Received 12 Jan, 2021
Review #12 received
Received 12 Jan, 2021
Review #10 received
Received 12 Jan, 2021
Review #1 received
Received 12 Jan, 2021
Reviewer #12 agreed
On 12 Jan, 2021
Reviewer #13 agreed
On 12 Jan, 2021
Reviewer #11 agreed
On 12 Jan, 2021
Reviewer #1 agreed
On 12 Jan, 2021
Reviewer #2 agreed
On 12 Jan, 2021
Reviewers invited
Invitations sent on 06 Jan, 2021
Editor assigned
On 06 Jan, 2021
Editor invited
On 22 Dec, 2020
Submission checks complete
On 22 Dec, 2020
First submitted
On 21 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
There is still no consensus on how to determine the dose of spinal anaesthesia with adequate sensory block for a planned surgery. This retrospective study aimed to explore the associations of miscellaneous factors with peak sensory block level after spinal anaesthesia with hyperbaric bupivacaine, and to construct a predictive model for single-shot spinal anaesthesia. We collected the records of 401 non-pregnant adults who underwent spinal anaesthesia with 0.5% hyperbaric bupivacaine at the L3-4 or L4-5 intervertebral space for lower body surgeries. Multiple linear regression analysis was used to investigate predictors of the block level and build up the predictive model. Five variables were identified as independent predictors of the peak sensory block level, including bupivacaine dose, height, weight, gender and age. The predictive model for peak block level after spinal anaesthesia could be expressed as a formula with these five variables and the estimated predictive power was 0.72. Based on this model, it is possible to determine a reasonable dose of hyperbaric bupivacaine for spinal anaesthesia, which gives adequate sensory block required for diverse surgical procedures in various patients and could be considered as a dose reference for sensory block height in spinal anaesthesia.