This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Zhijun Bao
Huadong Hospital Affiliated to Fudan University, 221 West Yan an Road, Shanghai, 200040, China.
Corresponding Author
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Growth differentiation factor 11 (GDF11) has been implicated in rejuvenative functions in age-related diseases. The molecular mechanisms connecting GDF11 with these anti-aging phenomena (reverse age-related cardiac hypertrophy, vascular and neurogenic rejuvenation, et al.) are still unclear. In this study, we aim to uncover the molecular functions of GDF11 using bioinformatics and network-driven analyses at human gene and transcription levels using gene co-expression network analysis and transcription factor network analysis. Our data suggests that GDF11 is involved in variety of functions such as apoptosis, DNA repair and telomere maintenance and interaction with key transcription factors such as MYC proto-oncogene (MYC), specificity protein 1 (SP1) and ETS proto oncogene 2 (ETS2). Our findings shed lights on the functions of GDF11 and provide insights into the role of GDF11 in aging.
Keywords
GDF11, anti-aging, bioinformatics analysis, apoptosis, DNA Repair, telomere maintenance
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Zhijun Bao
Huadong Hospital Affiliated to Fudan University, 221 West Yan an Road, Shanghai, 200040, China.
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 29 Dec, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Growth differentiation factor 11 (GDF11) has been implicated in rejuvenative functions in age-related diseases. The molecular mechanisms connecting GDF11 with these anti-aging phenomena (reverse age-related cardiac hypertrophy, vascular and neurogenic rejuvenation, et al.) are still unclear. In this study, we aim to uncover the molecular functions of GDF11 using bioinformatics and network-driven analyses at human gene and transcription levels using gene co-expression network analysis and transcription factor network analysis. Our data suggests that GDF11 is involved in variety of functions such as apoptosis, DNA repair and telomere maintenance and interaction with key transcription factors such as MYC proto-oncogene (MYC), specificity protein 1 (SP1) and ETS proto oncogene 2 (ETS2). Our findings shed lights on the functions of GDF11 and provide insights into the role of GDF11 in aging.
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
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