The coagulation test is used to diagnose the hematological diseases. Little is known about correlation between the coagulation test and neonatal hyperbilirubinemia. The aim of the study was to describe neonatal coagulation test in infants with neonatal hyperbilirubinemia.
Data were collected from newborns who had neonatal hyperbilirubinemia and healthy in Chengdu Second People’s Hospital. Prothrombin time(PT), Thrombin time(TT), Fibrinogen(Fbg), activated partial thromboplastin time(APTT), and calculated international normalized ration(INR) values were recorded. Linear relationship between INR and level of total bilirubin and indirect bilirubin were analysed by linear regression. Comparisons of two groups were made by GraphPad Prism 8.
In this case-control study, the mean PT, APTT level were significant higher in the infants with hyperbilirubinemia group compared to the healthy infants. We found the correlation between INR and total bilirubin(R = 0.3327; P < 0.0001). There was also correlation between INR and indirect bilirubin(R = 0.3402; P < 0.0001).
PT, APTT were significant high in neonatal hyperbilirubinemia group. Correlation were observed between the coagulation test and neonatal hyperbilirubinemia.