Hypoxia Modulation by Dual-drug Nanoparticles for Enhanced Synergistic Sonodynamic and Starvation Therapy
Background: Sonodynamic therapy (SDT) is an emerging non-invasive therapeutic technique. SDT-based cancer therapy strategies are presently underway, and it may be perceived as a promising approach to improve the efficiency of anti-cancer treatment. In this work, multifunctional theranostic nanoparticles (NPs) were synthesized for synergistic starvation therapy and SDT by loading glucose oxidase (GOx, termed G) and 5,10,15,20-tetrakis (4-chlorophenyl) porphyrin) Cl (T (p-Cl) PPMnCl, termed PMnC) in Poly (lactic-co-glycolic) acid (PLGA) NPs (designated as [email protected] NPs).
Results: On account of the peroxidase-like activity of PMnC, [email protected] NPs can catalyze hydrogen peroxide (H2O2) in tumor regions to produce oxygen (O2), thus enhancing synergistic therapeutic effects by accelerating the decomposition of glucose and promoting the production of cytotoxic singlet oxygen (1O2) induced by ultrasound (US) irradiation. Furthermore, the NPs can also serve as excellent photoacoustic (PA)/magnetic resonance (MR) imaging contrast agents, effectuating imaging-guided cancer treatment.
Conclusion: Multifunctional [email protected] NPs can effectuate the synergistic amplification effect of cancer starvation therapy and SDT by hypoxia modulation, and act as contrast agents to enhance MR/PA dual-modal imaging. Consequently, [email protected] NPs might be a promising nano-platform for highly efficient cancer theranostics.
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Scheme 1. The preparation route of [email protected] NPs and Schematic illustration of the multifunctional NPs for MR/PA dual imaging-guiaded synergistic amplification therapy.
Posted 30 Dec, 2020
On 15 Jan, 2021
On 14 Jan, 2021
On 14 Jan, 2021
Invitations sent on 29 Dec, 2020
On 23 Dec, 2020
On 23 Dec, 2020
On 23 Dec, 2020
On 22 Dec, 2020
Hypoxia Modulation by Dual-drug Nanoparticles for Enhanced Synergistic Sonodynamic and Starvation Therapy
Posted 30 Dec, 2020
On 15 Jan, 2021
On 14 Jan, 2021
On 14 Jan, 2021
Invitations sent on 29 Dec, 2020
On 23 Dec, 2020
On 23 Dec, 2020
On 23 Dec, 2020
On 22 Dec, 2020
Background: Sonodynamic therapy (SDT) is an emerging non-invasive therapeutic technique. SDT-based cancer therapy strategies are presently underway, and it may be perceived as a promising approach to improve the efficiency of anti-cancer treatment. In this work, multifunctional theranostic nanoparticles (NPs) were synthesized for synergistic starvation therapy and SDT by loading glucose oxidase (GOx, termed G) and 5,10,15,20-tetrakis (4-chlorophenyl) porphyrin) Cl (T (p-Cl) PPMnCl, termed PMnC) in Poly (lactic-co-glycolic) acid (PLGA) NPs (designated as [email protected] NPs).
Results: On account of the peroxidase-like activity of PMnC, [email protected] NPs can catalyze hydrogen peroxide (H2O2) in tumor regions to produce oxygen (O2), thus enhancing synergistic therapeutic effects by accelerating the decomposition of glucose and promoting the production of cytotoxic singlet oxygen (1O2) induced by ultrasound (US) irradiation. Furthermore, the NPs can also serve as excellent photoacoustic (PA)/magnetic resonance (MR) imaging contrast agents, effectuating imaging-guided cancer treatment.
Conclusion: Multifunctional [email protected] NPs can effectuate the synergistic amplification effect of cancer starvation therapy and SDT by hypoxia modulation, and act as contrast agents to enhance MR/PA dual-modal imaging. Consequently, [email protected] NPs might be a promising nano-platform for highly efficient cancer theranostics.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Due to technical limitations, full-text HTML conversion of this manuscript could not be completed. However, the manuscript can be downloaded and accessed as a PDF.