[1] Kaye AD. Tramadol, pharmacology, side effects, and serotonin syndrome: a review. ASIPP 2015;18: 395-400.
[2] Randall C, Crane J. Tramadol deaths in Northern Ireland: a review of cases from 1996 to 2012. Journal of forensic and legal medicine 2014;23: 32-36.
[3] Lagard C, Chevillard L, Malissin I, Risède P, Callebert J, Labat L, Launay J-M, Laplanche J-L, Mégarbane B. Mechanisms of tramadol-related neurotoxicity in the rat: Does diazepam/tramadol combination play a worsening role in overdose? Toxicology and Applied Pharmacology 2016;310: 108-119.
[4] Lagard C, Malissin I, Indja W, Risède P, Chevillard L, Mégarbane B. Is naloxone the best antidote to reverse tramadol-induced neuro-respiratory toxicity in overdose? An experimental investigation in the rat. Clinical Toxicology 2017: 1-7.
[5] Barbosa J, Faria J, Leal S, Afonso LP, Lobo J, Queirós O, Moreira R, Carvalho F, Dinis-Oliveira RJ. Acute administration of tramadol and tapentadol at effective analgesic and maximum tolerated doses causes hepato-and nephrotoxic effects in Wistar rats. Toxicology 2017;389: 118-129.
[6] Abdel-Zaher AO, Abdel-Rahman MS, ELwasei FM. Protective effect of Nigella sativa oil against tramadol-induced tolerance and dependence in mice: role of nitric oxide and oxidative stress. Neurotoxicology 2011;32: 725-733.
[7] Samaka R, Girgis N, Shams T. Acute toxicity and dependence of tramadol in albino rats: relationship of nestin and notch 1 as stem cell markers. J. of American Science 2012;8: 313-327.
[8] Ghoneim FM, Khalaf HA, Elsamanoudy AZ, Helaly AN. Effect of chronic usage of tramadol on motor cerebral cortex and testicular tissues of adult male albino rats and the effect of its withdrawal: histological, immunohistochemical and biochemical study. International journal of clinical and experimental pathology 2014;7: 7323.
[9] Baghishani F, Mohammadipour A, Hosseinzadeh H, Hosseini M, Ebrahimzadeh-bideskan A. The effects of tramadol administration on hippocampal cell apoptosis, learning and memory in adult rats and neuroprotective effects of crocin. Metabolic brain disease 2018: 1-10.
[10] Atici S, Cinel L, Cinel I, Doruk N, Aktekin M, Akca A, Camdeviren H, Oral U. Opioid neurotoxicity: comparison of morphine and tramadol in an experimental rat model. International journal of neuroscience 2004;114: 1001-1011.
[11] Eizadi-Mood N, Ozcan D, Sabzghabaee AM, Mirmoghtadaee P, Hedaiaty M. Does naloxone prevent seizure in tramadol intoxicated patients? International journal of preventive medicine 2014;5: 302.
[12] Fujimoto Y, Funao T, Suehiro K, Takahashi R, Mori T, Nishikawa K. Brain serotonin content regulates the manifestation of tramadol-induced seizures in ratsdisparity between tramadol-induced seizure and serotonin syndrome. Anesthesiology: The Journal of the American Society of Anesthesiologists 2015;122: 178-189.
[13] Hara K, Minami K, Sata T. The effects of tramadol and its metabolite on glycine, γ-aminobutyric AcidA, and N-methyl-d-aspartate receptors expressed in Xenopus oocytes. Anesthesia & Analgesia 2005;100: 1400-1405.
[14] Saidi H, Ghadiri M, Abbasi S, Ahmadi S-F. Efficacy and safety of naloxone in the management of postseizure complaints of tramadol intoxicated patients: a self-controlled study. Emergency Medicine Journal 2010: emj. 2009.083162.
[15] Farzaneh E, Mostafazadeh B, Mehrpour O. Seizurogenic effects of low-dose naloxone in tramadol overdose. Iranian Journal of Pharmacology and Therapeutics 2012;11: 6-0.
[16] Shadnia S, Brent J, Mousavi‐Fatemi K, Hafezi P, Soltaninejad K. Recurrent seizures in tramadol intoxication: implications for therapy based on 100 patients. Basic & clinical pharmacology & toxicology 2012;111: 133-136.
[17] Tashakori A, Afshari R. Tramadol overdose as a cause of serotonin syndrome: a case series. Clinical Toxicology 2010;48: 337-341.
[18] Clarot F, Goulle J, Vaz E, Proust B. Fatal overdoses of tramadol: is benzodiazepine a risk factor of lethality? Forensic science international 2003;134: 57-61.
[19] Moghbelinejad S, Alizadeh S, Mohammadi G, Khodabandehloo F, Rashvand Z, Najafipour R, Nassiri-Asl M. The effects of quercetin on the gene expression of the GABA A receptor α5 subunit gene in a mouse model of kainic acid-induced seizure. The Journal of Physiological Sciences 2017;67: 339-343.
[20] Nassiri-Asl M, Hajiali F, Taghiloo M, Abbasi E, Mohseni F, Yousefi F. Comparison between the effects of quercetin on seizure threshold in acute and chronic seizure models. Toxicology and industrial health 2016;32: 936-944.
[21] Abdalla FH, Schmatz R, Cardoso AM, Carvalho FB, Baldissarelli J, de Oliveira JS, Rosa MM, Nunes MAG, Rubin MA, da Cruz IB. Quercetin protects the impairment of memory and anxiogenic-like behavior in rats exposed to cadmium: Possible involvement of the acetylcholinesterase and Na+, K+-ATPase activities. Physiology & behavior 2014;135: 152-167.
[22] Nassiri-Asl M, Moghbelinejad S, Abbasi E, Yonesi F, Haghighi M-R, Lotfizadeh M, Bazahang P. Effects of quercetin on oxidative stress and memory retrieval in kindled rats. Epilepsy & Behavior 2013;28: 151-155.
[23] Nieoczym D, Socała K, Raszewski G, Wlaź P. Effect of quercetin and rutin in some acute seizure models in mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2014;54: 50-58.
[24] Cavas M, Beltrán D, Navarro JF. Behavioural effects of dimethyl sulfoxide (DMSO): changes in sleep architecture in rats. Toxicology letters 2005;157: 221-232.
[25] Malfará WR, Souza AMd, Queiroz RHC. Ranitidine treatment inducing methemoglobinemia in male Wistar rats. Revista Brasileira de Ciências Farmacêuticas 2005;41: 247-252.
[26] Arifin WN, Zahiruddin WM. Sample size calculation in animal studies using resource equation approach. The Malaysian journal of medical sciences: MJMS 2017;24: 101.
[27] Grin’kina NM, Li Y, Haber M, Sangobowale M, Nikulina E, Le’Pre C, El Sehamy AM, Dugue R, Ho JS, Bergold PJ. Righting Reflex Predicts Long-Term Histological and Behavioral Outcomes in a Closed Head Model of Traumatic Brain Injury. PloS one 2016;11: e0161053.
[28] Jackson HC, Nutt D. Investigation of the involvement of opioid receptors in the action of anticonvulsants. Psychopharmacology 1993;111: 486-490.
[29] Rehni AK, Singh I, Kumar M. Tramadol‐Induced Seizurogenic Effect: A Possible Role of Opioid‐Dependent γ‐Aminobutyric Acid Inhibitory Pathway. Basic & clinical pharmacology & toxicology 2008;103: 262-266.
[30] Gilbert P, Martin W. Antagonism of the convulsant effects of heroin, d-propoxyphene, meperidine, normeperidine and thebaine by naloxone in mice. Journal of Pharmacology and Experimental Therapeutics 1975;192: 538-541.
[31] Yang L, Li F, Ge W, Mi C, Wang R, Sun R. Protective effects of naloxone in two‐hit seizure model. Epilepsia 2010;51: 344-353.
[32] Wermeling DP. Review of naloxone safety for opioid overdose: practical considerations for new technology and expanded public access. Therapeutic advances in drug safety 2015;6: 20-31.
[33] Raffa RB, Stone DJ. Unexceptional seizure potential of tramadol or its enantiomers or metabolites in mice. Journal of pharmacology and experimental therapeutics 2008;325: 500-506.
[34] Nakhaee S, Amirabadizadeh A, Brent J, Miri-Moghaddam E, Foadoddini M, Farrokhfall K, Hosseini M, Abdollahi M, Mehrpour O. Tramadol and the occurrence of seizures: a systematic review and meta-analysis. Critical reviews in toxicology 2019;49: 710-723.
[35] Jovanović-Čupić V, Martinović Ž, Nešić N. Seizures associated with intoxication and abuse of tramadol. Clinical toxicology 2006;44: 143-146.
[36] Clarot F, Proust B, Vaz E, Goullé J. Tramadol-benzodiazepines and buprenorphine-benzodiazepines: two potentially fatal cocktails? Journal of clinical forensic medicine 2003;10: 125-126.
[37] Nassiri-Asl M, Naserpour Farivar T, Abbasi E, Sadeghnia HR, Sheikhi M, Lotfizadeh M, Bazahang P. Effects of rutin on oxidative stress in mice with kainic acid-induced seizure. Journal of integrative medicine 2013;11: 337-342.
[38] Dajas F, Juan Andres A-C, Florencia A, Carolina E, Felicia R-M. Neuroprotective actions of flavones and flavonols: mechanisms and relationship to flavonoid structural features. Central Nervous System Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Central Nervous System Agents) 2013;13: 30-35.
[39] Lee B-H, Lee J-H, Yoon I-S, Lee J-H, Choi S-H, Pyo MK, Jeong SM, Choi W-S, Shin T-J, Lee S-M. Human glycine α1 receptor inhibition by quercetin is abolished or inversed by α267 mutations in transmembrane domain 2. Brain research 2007;1161: 1-10.
[40] Lee B-H, Jung S-M, ngo Lee J-H, Kim J-H, Yoon I-S, Lee J-H, Choi S-H, Lee S-M, Chang C-G, Kim H-C. Quercetin Inhibits the 5-Hydroxytryptamine Type 3 Receptormediated Ion Current by Interacting with Pre-Transmembrane Domain I. Molecules & Cells (Springer Science & Business Media BV) 2005;20.
[41] Alexander SP. Flavonoids as antagonists at A1 adenosine receptors. Phytotherapy Research: An international journal devoted to pharmacological and toxicological evaluation of natural product derivatives 2006;20: 1009-1012.
[42] Marquardt KA, Alsop JA, Albertson TE. Tramadol exposures reported to statewide poison control system. Annals of Pharmacotherapy 2005;39: 1039-1044.
[43] Shadnia S, Soltaninejad K, Heydari K, Sasanian G, Abdollahi M. Tramadol intoxication: a review of 114 cases. Human & experimental toxicology 2008;27: 201-205.
[44] Hassanian-Moghaddam H, Farajidana H, Sarjami S, Owliaey H. Tramadol-induced apnea. The American journal of emergency medicine 2013;31: 26-31.