This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Basit Jabbar
Centre of Excellence in Molecular Biology, 87 West Canal Bank Road, Thokar Niazbaig, Lahore, 53700, Pakistan.
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Diabetes mellitus (DM) is a global health problem with 422 million individuals around the world suffering from diabetes. Coriandrum sativum and Allium sativum possess numerous bioactive compounds which are of therapeutical significance. This study was undertaken to explore the combined potential of the two herbs in managing diabetes using diabetic albino mice as model. Extracts of both herbs were prepared and were orally administered in 10% Alloxan monohydrate (alloxan) induced diabetic albino mice over 28 days (in four doses with 7 day interval) to determine the optimal therapeutic and lethal doses. Safe dose limit of both extracts was deduced to be below 600 mg/kg (<600 mg/kg). Diabetic mice were given extracts (200 mg/kg and 400 mg/kg) over 56 days at 7 day intervals, and biological parameters were evaluated, at each interval, including Glucose level (mg/dl), HbA1C (%), Hepatic and Renal biomarkers, and Lipid profile. Garlic-coriander combination (at 400 mg/kg) was able to reduce glucose level (i.e.194.5 mg/dl) (P<0.05). Also, it showed a worthwhile effect on biological parameters as well as in Hepatic and renal tissues. Histological examination of hepatic and renal tissues indicated a restoration of normal tissue 26 architecture.
Keywords
Diabetes mellitus (DM), Coriandrum sativum, Allium sativum, renal tissues
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The full text of this article is available to read as a PDF.
This is a list of supplementary files associated with this preprint. Click to download.
- SUPPLEMENTARYMATERIAL.docx
The authors declare that there is no conflict of interest.
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Basit Jabbar
Centre of Excellence in Molecular Biology, 87 West Canal Bank Road, Thokar Niazbaig, Lahore, 53700, Pakistan.
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 06 Jan, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Molecular Biology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Diabetes mellitus (DM) is a global health problem with 422 million individuals around the world suffering from diabetes. Coriandrum sativum and Allium sativum possess numerous bioactive compounds which are of therapeutical significance. This study was undertaken to explore the combined potential of the two herbs in managing diabetes using diabetic albino mice as model. Extracts of both herbs were prepared and were orally administered in 10% Alloxan monohydrate (alloxan) induced diabetic albino mice over 28 days (in four doses with 7 day interval) to determine the optimal therapeutic and lethal doses. Safe dose limit of both extracts was deduced to be below 600 mg/kg (<600 mg/kg). Diabetic mice were given extracts (200 mg/kg and 400 mg/kg) over 56 days at 7 day intervals, and biological parameters were evaluated, at each interval, including Glucose level (mg/dl), HbA1C (%), Hepatic and Renal biomarkers, and Lipid profile. Garlic-coriander combination (at 400 mg/kg) was able to reduce glucose level (i.e.194.5 mg/dl) (P<0.05). Also, it showed a worthwhile effect on biological parameters as well as in Hepatic and renal tissues. Histological examination of hepatic and renal tissues indicated a restoration of normal tissue 26 architecture.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
The full text of this article is available to read as a PDF.
This is a list of supplementary files associated with this preprint. Click to download.
- SUPPLEMENTARYMATERIAL.docx
The authors declare that there is no conflict of interest.
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