Phoenix is the surname of seventeen palm species (canariensis, dactylifera, reclinata, sabal, rupicola.. .etc.) which a member of the palmate family1. For many people living in Yemen and other dry areas of the world, the feather palm (Phoenix dactylifera L.) plays a significant social, environmental, and economic role. The fruits of the feather palm are widely consumed in many parts of the world and are considered a major part of the diet and a staple food in most Arab countries, The seeds of Phoenix dactylifera L. (Arecaceae) have been found to contain a wide range of inhibitors.2 Many studies have examined the chemical composition of P. dactylifera seeds, revealing the existence of large amounts of phenolics, flavonoids, and amino acids, all of which are responsible for radical scavenging and medicinal operation3,4,5. According to a recent phytochemical study, the flavonoid content in P. dactylifera seeds is rutin and quercetin and, which are increased by preparation.6Phoenix dactylifera L. (date palm) is a plant used in folk medicine to treat a variety of diseases and disorders, Dates and its constituents act as potent inhibitors, medicinal drugs, and antitumoral agents and provide an appropriate variety of medical aids in the treatment of various diseases.7
Diabetes may be a significant pathological condition, affects one-fifth of the world's population. Diabetes mellitus is a multi-etiological condition characterized by chronic symptoms,8 due to insufficient insulin hormone production or cells that do not respond to the hormones produced9. Diabetes mellitus is a condition in which the body produces insufficient insulin, stops producing insulin, or becomes increasingly resistant to its activity10. In patients with the polygenic condition, effective glucose control is the key to preventing diabetic complications and improving quality of life.2,7 The ability of insulin hormone to mediate tissue glucose uptake may be a critical step in preserving the physiological state of glucose and clearing the postprandial glucose load.11,12 In 2019, 463 million people worldwide have diabetes, accounting for 9.3% of the global population, with 80% of those living in low and middle-income nations. According to estimates, 2045, 700 million people will make up 10.9 percent of the global population.13,14
Diabetes mellitus can cause symptoms such as thirst, polyuria, blurred vision, and weight loss. Several pathogenic processes are involved in the development of polygenic disorders. With sequential hormone deficiency, represents processes that destroy pancreatic beta cells. Abnormalities in sugar, fat, and macromolecule metabolism are caused by a lack of hormone action on course tissues as a result of hormone inability or lack.8
For a long time, diabetes has been treated using a variety of medicinal plants, with medicinal plant extracts being reported to improve diabetic control while reducing related adverse effects when compared to synthetic medications.15
Dexamethasone is a sex hormone. Steroids increase glucose levels in three ways: they block the action of insulin, which causes hormone resistance, and less glucose is ready to move out of the blood to be concerned by the muscles. This causes the liver to release additional glucose into the blood, resulting in a high glucose level16. Dexamethasone use utilize to improve analgesia and reduce the incidence of nausea and vomiting. Dexamethasone, on the other hand, has the potential to raise blood glucose levels, which is a known risk factor for problems17. The hypoglycemic effects of various components of various palm species have been reported in some studies.
In a recent study, the liquid extract of P. dactylifera seeds was found to be capable of stimulating endogenous hormone secretion through additional sources, which may be the mechanism of its hypoglycemic action.11 Another study found that a fruit extract of P. dactylifera has a protective effect against diabetic pathology in rats12. Many indigenous medicinal herbs and extracts from various sections of these plants such as roots, shoots, and seeds. have been used in the management of diabetes18 due of the different active phytochemicals present in these plants.
However, the goal of this research was to assess the possibility of using the date palm seed as an anti-diabetic agent in non-diabetic and diabetic rabbits induced by dexamethasone; the Methanolic extract of the seed had a hypoglycemic effect.