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Research Article
Inhibition of Switch-on Fluorescence of Fluorochrome on Loading TiO2 with Gold
Jayamoorthy K
St.Joseph's College of Engineering
Corresponding Author
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Gold loaded TiO2 nanoparticles have been synthesized and characterized by powder XRD, HR-TEM, and EDX analysis. The binding interaction of fluorescent sensor 5-amino-2-mercaptobenzimidazole (fluorochrome) with TiO2 and gold loaded TiO2 nanoparticles has been discussed herein. The interaction of fluorochrome with TiO2 and gold loaded TiO2 nanoparticles has been studied by UV-visible, fluorescence, and FT-IR spectral techniques. The fluorescence emission occurs at 421 nm and this has been selectively enhanced by TiO2 nano semiconductor. This technique is sensitive to detect and estimate TiO2 nano semiconductor at a micromolar level. This switch-on fluorescence is suppressed when it is loaded with gold. The strong adsorption of fluorochrome over the surface of nano semiconductor results in the electron transfer between fluorochrome and nano semiconductor. Further, the binding site of nano semiconductor with fluorochrome has been studied theoretically by using the molecular electrostatic potential (MEP). The results show higher electron density at the azomethine nitrogen atom.
Keywords
Fluorochrome, Gold loaded TiO2 nanoparticles, Fluorescence, Electron transfer
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Reviewer #1 agreed
On 15 Jan, 2021
Reviewer #2 agreed
On 15 Jan, 2021
Reviewer #4 agreed
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Reviewer #3 agreed
On 15 Jan, 2021
Reviewer #5 agreed
On 15 Jan, 2021
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This preprint is under consideration at Scientific Reports. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Inhibition of Switch-on Fluorescence of Fluorochrome on Loading TiO2 with Gold
Jayamoorthy K
St.Joseph's College of Engineering
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 08 Jan, 2021
No community comments so far
Reviewer #1 agreed
On 15 Jan, 2021
Reviewer #2 agreed
On 15 Jan, 2021
Reviewer #4 agreed
On 15 Jan, 2021
Reviewer #3 agreed
On 15 Jan, 2021
Reviewer #5 agreed
On 15 Jan, 2021
Reviewers invited
Invitations sent on 14 Jan, 2021
Editor assigned
On 13 Jan, 2021
Editor invited
On 05 Jan, 2021
Submission checks complete
On 05 Jan, 2021
First submitted
On 04 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Gold loaded TiO2 nanoparticles have been synthesized and characterized by powder XRD, HR-TEM, and EDX analysis. The binding interaction of fluorescent sensor 5-amino-2-mercaptobenzimidazole (fluorochrome) with TiO2 and gold loaded TiO2 nanoparticles has been discussed herein. The interaction of fluorochrome with TiO2 and gold loaded TiO2 nanoparticles has been studied by UV-visible, fluorescence, and FT-IR spectral techniques. The fluorescence emission occurs at 421 nm and this has been selectively enhanced by TiO2 nano semiconductor. This technique is sensitive to detect and estimate TiO2 nano semiconductor at a micromolar level. This switch-on fluorescence is suppressed when it is loaded with gold. The strong adsorption of fluorochrome over the surface of nano semiconductor results in the electron transfer between fluorochrome and nano semiconductor. Further, the binding site of nano semiconductor with fluorochrome has been studied theoretically by using the molecular electrostatic potential (MEP). The results show higher electron density at the azomethine nitrogen atom.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6