Background: Although psoriasis is considered a systemic disease, no clear association has been established between psoriasis and lung diseases.
Methods: Adult psoriasis patients with no known active pulmonary disease or respiratory symptoms were screened for subclinical pulmonary manifestations and possible parenchymal changes using high-resolution computed tomography (HRCT) scan of the chest. Patients were classified according to the severity of skin manifestations. The clinical characteristics and radiographic findings of these patients were evaluated.
Results: A total of 59 patients with psoriasis were included, among which 47 (79.7%) had abnormal HRCT scan features. Micronodules were the most common detected lung lesions (66.1%), followed by interlobular septal thickening (23.7%), fibrosis (11.9%), and ground-glass opacity (6.8%). Other HRCT findings included emphysematous changes and calcified granulomas. Abnormal HRCT findings correlated with older age and duration of psoriasis but not with the severity of skin manifestations.
Conclusions: Micronodules and interlobular septal thickening were the most detected lung lesions in patients with psoriasis. These findings of the pilot study highlight the possible pulmonary involvement in patients with psoriasis. Larger multicenter studies are needed to further clarify these findings.