Body mass index in relation to prostate specific antigen-related parameters
Purpose Only a few previous studies were conducted to assess the association between body mass index (BMI) and prostate-specific antigen (PSA) related parameters which take prostate volume (PV) and blood volume (BV) into consideration. The objective of this study was to assess the relationship between BMI and parameters of PSA concentrations in Chinese adult male.
Methods A total of 86,930 men who have taken annual physical examination at the First Affiliated Hospital of Army Medical University from 1 January 2011 to 31 December 2018 were included in this study. Partial Spearman correlation rank test was performed to assess the relationship between BMI, PV, BV and PSA, and analyze the correlation between BMI and PSA related parameters.
Results After adjustment for age, PV (correlation coefficient = 0.227, P-value < 0.001) was positively associated with PSA levels, while BMI (correlation coefficient = -0.057, P-value < 0.001) and BV (correlation coefficient = -0.041, P-value < 0.001) were inversely correlated to PSA concentrations. The analysis also indicated that BMI positively associated with PV and BV. Furthermore, the present study identified that PSA mass (correlation coefficient = 0.001, P-value = 0.763), after adjustment for age, was not affected by obesity in Chinese men.
Conclusion The findings of this large-sample, hospital-based study in China indicated that a higher BMI is associated with an increased PV and BV. BMI was negatively associated with PSA and PAS density, and no statistically significant association was found between BMI and PSA mass.
Posted 05 Jun, 2020
On 03 Jul, 2020
Received 24 Jun, 2020
On 19 Jun, 2020
On 18 Jun, 2020
Received 18 Jun, 2020
Received 18 Jun, 2020
On 17 Jun, 2020
Invitations sent on 17 Jun, 2020
On 17 Jun, 2020
On 16 Jun, 2020
On 02 Jun, 2020
On 03 Mar, 2020
Received 03 Mar, 2020
Received 02 Mar, 2020
Received 27 Feb, 2020
Received 27 Feb, 2020
Received 21 Feb, 2020
On 20 Feb, 2020
On 19 Feb, 2020
Invitations sent on 17 Feb, 2020
On 17 Feb, 2020
On 17 Feb, 2020
On 17 Feb, 2020
On 09 Feb, 2020
On 08 Feb, 2020
On 08 Feb, 2020
On 06 Feb, 2020
Body mass index in relation to prostate specific antigen-related parameters
Posted 05 Jun, 2020
On 03 Jul, 2020
Received 24 Jun, 2020
On 19 Jun, 2020
On 18 Jun, 2020
Received 18 Jun, 2020
Received 18 Jun, 2020
On 17 Jun, 2020
Invitations sent on 17 Jun, 2020
On 17 Jun, 2020
On 16 Jun, 2020
On 02 Jun, 2020
On 03 Mar, 2020
Received 03 Mar, 2020
Received 02 Mar, 2020
Received 27 Feb, 2020
Received 27 Feb, 2020
Received 21 Feb, 2020
On 20 Feb, 2020
On 19 Feb, 2020
Invitations sent on 17 Feb, 2020
On 17 Feb, 2020
On 17 Feb, 2020
On 17 Feb, 2020
On 09 Feb, 2020
On 08 Feb, 2020
On 08 Feb, 2020
On 06 Feb, 2020
Purpose Only a few previous studies were conducted to assess the association between body mass index (BMI) and prostate-specific antigen (PSA) related parameters which take prostate volume (PV) and blood volume (BV) into consideration. The objective of this study was to assess the relationship between BMI and parameters of PSA concentrations in Chinese adult male.
Methods A total of 86,930 men who have taken annual physical examination at the First Affiliated Hospital of Army Medical University from 1 January 2011 to 31 December 2018 were included in this study. Partial Spearman correlation rank test was performed to assess the relationship between BMI, PV, BV and PSA, and analyze the correlation between BMI and PSA related parameters.
Results After adjustment for age, PV (correlation coefficient = 0.227, P-value < 0.001) was positively associated with PSA levels, while BMI (correlation coefficient = -0.057, P-value < 0.001) and BV (correlation coefficient = -0.041, P-value < 0.001) were inversely correlated to PSA concentrations. The analysis also indicated that BMI positively associated with PV and BV. Furthermore, the present study identified that PSA mass (correlation coefficient = 0.001, P-value = 0.763), after adjustment for age, was not affected by obesity in Chinese men.
Conclusion The findings of this large-sample, hospital-based study in China indicated that a higher BMI is associated with an increased PV and BV. BMI was negatively associated with PSA and PAS density, and no statistically significant association was found between BMI and PSA mass.