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Research article
Body mass index in relation to prostate specific antigen-related parameters
Zongtao Chen
the first affiliated hospital of army medical university
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose Only a few previous studies were conducted to assess the association between body mass index (BMI) and prostate-specific antigen (PSA) related parameters which take prostate volume (PV) and blood volume (BV) into consideration. The objective of this study was to assess the relationship between BMI and parameters of PSA concentrations in Chinese adult male.
Methods A total of 86,930 men who have taken annual physical examination at the First Affiliated Hospital of Army Medical University from 1 January 2011 to 31 December 2018 were included in this study. Partial Spearman correlation rank test was performed to assess the relationship between BMI, PV, BV and PSA, and analyze the correlation between BMI and PSA related parameters.
Results After adjustment for age, PV (correlation coefficient = 0.227, P-value < 0.001) was positively associated with PSA levels, while BMI (correlation coefficient = -0.057, P-value < 0.001) and BV (correlation coefficient = -0.041, P-value < 0.001) were inversely correlated to PSA concentrations. The analysis also indicated that BMI positively associated with PV and BV. Furthermore, the present study identified that PSA mass (correlation coefficient = 0.001, P-value = 0.763), after adjustment for age, was not affected by obesity in Chinese men.
Conclusion The findings of this large-sample, hospital-based study in China indicated that a higher BMI is associated with an increased PV and BV. BMI was negatively associated with PSA and PAS density, and no statistically significant association was found between BMI and PSA mass.
Keywords
Body mass index, Prostate specific antigen, Prostate specific antigen density, Prostate specific antigen mass
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CURRENT STATUS: Under Revision
Version 2
Posted 05 Jun, 2020
No community comments so far
Editorial decision: Major revision
On 03 Jul, 2020
Review #3 received
Received 24 Jun, 2020
Reviewer #3 agreed
On 19 Jun, 2020
Reviewer #2 agreed
On 18 Jun, 2020
Review #1 received
Received 18 Jun, 2020
Review #2 received
Received 18 Jun, 2020
Editor assigned
On 17 Jun, 2020
Reviewers invited
Invitations sent on 17 Jun, 2020
Reviewer #1 agreed
On 17 Jun, 2020
Editor invited
On 16 Jun, 2020
Submission checks complete
On 02 Jun, 2020
No comments provided
Editorial decision: Major revision
On 03 Mar, 2020
Review #5 received
Received 03 Mar, 2020
Review #4 received
Received 02 Mar, 2020
Review #2 received
Received 27 Feb, 2020
Review #3 received
Received 27 Feb, 2020
Review #1 received
Received 21 Feb, 2020
Reviewer #5 agreed
On 20 Feb, 2020
Reviewer #4 agreed
On 19 Feb, 2020
Reviewers invited
Invitations sent on 17 Feb, 2020
Reviewer #1 agreed
On 17 Feb, 2020
Reviewer #2 agreed
On 17 Feb, 2020
Reviewer #3 agreed
On 17 Feb, 2020
Editor assigned
On 09 Feb, 2020
Submission checks complete
On 08 Feb, 2020
Editor invited
On 08 Feb, 2020
First submitted
On 06 Feb, 2020
Metrics
Comments: 0
PDF Downloads: ...
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Subject Areas
Urology & Nephrology
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This preprint is under consideration at BMC Urology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Body mass index in relation to prostate specific antigen-related parameters
Zongtao Chen
the first affiliated hospital of army medical university
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Revision
Version 2
Posted 05 Jun, 2020
No community comments so far
Editorial decision: Major revision
On 03 Jul, 2020
Review #3 received
Received 24 Jun, 2020
Reviewer #3 agreed
On 19 Jun, 2020
Reviewer #2 agreed
On 18 Jun, 2020
Review #1 received
Received 18 Jun, 2020
Review #2 received
Received 18 Jun, 2020
Editor assigned
On 17 Jun, 2020
Reviewers invited
Invitations sent on 17 Jun, 2020
Reviewer #1 agreed
On 17 Jun, 2020
Editor invited
On 16 Jun, 2020
Submission checks complete
On 02 Jun, 2020
No comments provided
Editorial decision: Major revision
On 03 Mar, 2020
Review #5 received
Received 03 Mar, 2020
Review #4 received
Received 02 Mar, 2020
Review #2 received
Received 27 Feb, 2020
Review #3 received
Received 27 Feb, 2020
Review #1 received
Received 21 Feb, 2020
Reviewer #5 agreed
On 20 Feb, 2020
Reviewer #4 agreed
On 19 Feb, 2020
Reviewers invited
Invitations sent on 17 Feb, 2020
Reviewer #1 agreed
On 17 Feb, 2020
Reviewer #2 agreed
On 17 Feb, 2020
Reviewer #3 agreed
On 17 Feb, 2020
Editor assigned
On 09 Feb, 2020
Submission checks complete
On 08 Feb, 2020
Editor invited
On 08 Feb, 2020
First submitted
On 06 Feb, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Urology & Nephrology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose Only a few previous studies were conducted to assess the association between body mass index (BMI) and prostate-specific antigen (PSA) related parameters which take prostate volume (PV) and blood volume (BV) into consideration. The objective of this study was to assess the relationship between BMI and parameters of PSA concentrations in Chinese adult male.
Methods A total of 86,930 men who have taken annual physical examination at the First Affiliated Hospital of Army Medical University from 1 January 2011 to 31 December 2018 were included in this study. Partial Spearman correlation rank test was performed to assess the relationship between BMI, PV, BV and PSA, and analyze the correlation between BMI and PSA related parameters.
Results After adjustment for age, PV (correlation coefficient = 0.227, P-value < 0.001) was positively associated with PSA levels, while BMI (correlation coefficient = -0.057, P-value < 0.001) and BV (correlation coefficient = -0.041, P-value < 0.001) were inversely correlated to PSA concentrations. The analysis also indicated that BMI positively associated with PV and BV. Furthermore, the present study identified that PSA mass (correlation coefficient = 0.001, P-value = 0.763), after adjustment for age, was not affected by obesity in Chinese men.
Conclusion The findings of this large-sample, hospital-based study in China indicated that a higher BMI is associated with an increased PV and BV. BMI was negatively associated with PSA and PAS density, and no statistically significant association was found between BMI and PSA mass.