1. Jatoi, I.; Chen, B.E.; Anderson, W.F.; Rosenberg, P.S. Breast cancer mortality trends in the United States according to estrogen receptor status and age at diagnosis. J Clin Oncol 2007, 25, 1683-1690, doi:10.1200/JCO.2006.09.2106.
2. Siiteri, P.K. Adipose tissue as a source of hormones. Am J Clin Nutr 1987, 45, 277-282, doi:10.1093/ajcn/45.1.277.
3. Santoro, N.; Randolph, J.F., Jr. Reproductive hormones and the menopause transition. Obstet Gynecol Clin North Am 2011, 38, 455-466, doi:10.1016/j.ogc.2011.05.004.
4. Collaborative Group on Hormonal Factors in Breast, C. Type and timing of menopausal hormone therapy and breast cancer risk: individual participant meta-analysis of the worldwide epidemiological evidence. Lancet 2019, 394, 1159-1168, doi:10.1016/S0140-6736(19)31709-X.
5. Carroll, J.S.; Hickey, T.E.; Tarulli, G.A.; Williams, M.; Tilley, W.D. Deciphering the divergent roles of progestogens in breast cancer. Nat Rev Cancer 2017, 17, 54-64, doi:10.1038/nrc.2016.116.
6. Hussein, S.; Khanna, P.; Yunus, N.; Gatza, M.L. Nuclear Receptor-Mediated Metabolic Reprogramming and the Impact on HR+ Breast Cancer. Cancers (Basel) 2021, 13, doi:10.3390/cancers13194808.
7. Boonyaratanakornkit, V.; Pateetin, P. The role of ovarian sex steroids in metabolic homeostasis, obesity, and postmenopausal breast cancer: molecular mechanisms and therapeutic implications. Biomed Res Int 2015, 2015, 140196, doi:10.1155/2015/140196.
8. Frasor, J.; Danes, J.M.; Komm, B.; Chang, K.C.; Lyttle, C.R.; Katzenellenbogen, B.S. Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype. Endocrinology 2003, 144, 4562-4574, doi:10.1210/en.2003-0567.
9. Richer, J.K.; Jacobsen, B.M.; Manning, N.G.; Abel, M.G.; Wolf, D.M.; Horwitz, K.B. Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells. J Biol Chem 2002, 277, 5209-5218, doi:10.1074/jbc.M110090200 M110090200 [pii].
10. Boonyaratanakornkit, V.; McGowan, E.; Sherman, L.; Mancini, M.A.; Cheskis, B.J.; Edwards, D.P. The role of extranuclear signaling actions of progesterone receptor in mediating progesterone regulation of gene expression and the cell cycle. Mol Endocrinol 2007, 21, 359-375, doi:me.2006-0337 [pii] 10.1210/me.2006-0337.
11. Diep, C.H.; Daniel, A.R.; Mauro, L.J.; Knutson, T.P.; Lange, C.A. Progesterone action in breast, uterine, and ovarian cancers. J Mol Endocrinol 2015, 54, R31-53, doi:10.1530/JME-14-0252.
12. Chen, J.Q.; Delannoy, M.; Cooke, C.; Yager, J.D. Mitochondrial localization of ERalpha and ERbeta in human MCF7 cells. Am J Physiol Endocrinol Metab 2004, 286, E1011-1022, doi:10.1152/ajpendo.00508.2003.
13. Pedram, A.; Razandi, M.; Wallace, D.C.; Levin, E.R. Functional estrogen receptors in the mitochondria of breast cancer cells. Mol Biol Cell 2006, 17, 2125-2137, doi:10.1091/mbc.e05-11-1013.
14. Behera, M.A.; Dai, Q.; Garde, R.; Saner, C.; Jungheim, E.; Price, T.M. Progesterone stimulates mitochondrial activity with subsequent inhibition of apoptosis in MCF-10A benign breast epithelial cells. Am J Physiol Endocrinol Metab 2009, 297, E1089-1096, doi:10.1152/ajpendo.00209.2009.
15. Dai, Q.; Shah, A.A.; Garde, R.V.; Yonish, B.A.; Zhang, L.; Medvitz, N.A.; Miller, S.E.; Hansen, E.L.; Dunn, C.N.; Price, T.M. A truncated progesterone receptor (PR-M) localizes to the mitochondrion and controls cellular respiration. Mol Endocrinol 2013, 27, 741-753, doi:10.1210/me.2012-1292.
16. Tidwell, T.R.; Soreide, K.; Hagland, H.R. Aging, Metabolism, and Cancer Development: from Peto's Paradox to the Warburg Effect. Aging Dis 2017, 8, 662-676, doi:10.14336/AD.2017.0713.
17. Forbes, N.S.; Meadows, A.L.; Clark, D.S.; Blanch, H.W. Estradiol stimulates the biosynthetic pathways of breast cancer cells: detection by metabolic flux analysis. Metab Eng 2006, 8, 639-652, doi:10.1016/j.ymben.2006.06.005.
18. Schlaepfer, I.R.; Hitz, C.A.; Gijon, M.A.; Bergman, B.C.; Eckel, R.H.; Jacobsen, B.M. Progestin modulates the lipid profile and sensitivity of breast cancer cells to docetaxel. Mol Cell Endocrinol 2012, 363, 111-121, doi:10.1016/j.mce.2012.08.005.
19. Medina, R.A.; Meneses, A.M.; Vera, J.C.; Guzman, C.; Nualart, F.; Astuya, A.; Garcia, M.A.; Kato, S.; Carvajal, A.; Pinto, M.; et al. Estrogen and progesterone up-regulate glucose transporter expression in ZR-75-1 human breast cancer cells. Endocrinology 2003, 144, 4527-4535, doi:10.1210/en.2003-0294.
20. Finlay-Schultz, J.; Jacobsen, B.M.; Riley, D.; Paul, K.V.; Turner, S.; Ferreira-Gonzalez, A.; Harrell, J.C.; Kabos, P.; Sartorius, C.A. New generation breast cancer cell lines developed from patient-derived xenografts. Breast Cancer Res 2020, 22, 68, doi:10.1186/s13058-020-01300-y.
21. D'Alessandro, A.; Moore, H.B.; Moore, E.E.; Wither, M.; Nemkov, T.; Gonzalez, E.; Slaughter, A.; Fragoso, M.; Hansen, K.C.; Silliman, C.C.; et al. Early hemorrhage triggers metabolic responses that build up during prolonged shock. Am J Physiol Regul Integr Comp Physiol 2015, 308, R1034-1044, doi:10.1152/ajpregu.00030.2015.
22. D'Alessandro, A.; Nemkov, T.; Kelher, M.; West, F.B.; Schwindt, R.K.; Banerjee, A.; Moore, E.E.; Silliman, C.C.; Hansen, K.C. Routine storage of red blood cell (RBC) units in additive solution-3: a comprehensive investigation of the RBC metabolome. Transfusion 2015, 55, 1155-1168, doi:10.1111/trf.12975.
23. Gehrke, S.; Rice, S.; Stefanoni, D.; Wilkerson, R.B.; Nemkov, T.; Reisz, J.A.; Hansen, K.C.; Lucas, A.; Cabrales, P.; Drew, K.; et al. Red Blood Cell Metabolic Responses to Torpor and Arousal in the Hibernator Arctic Ground Squirrel. J Proteome Res 2019, doi:10.1021/acs.jproteome.9b00018.
24. Haug, K.; Cochrane, K.; Nainala, V.C.; Williams, M.; Chang, J.; Jayaseelan, K.V.; O'Donovan, C. MetaboLights: a resource evolving in response to the needs of its scientific community. Nucleic Acids Res 2020, 48, D440-D444, doi:10.1093/nar/gkz1019.
25. Chong, J.; Wishart, D.S.; Xia, J. Using MetaboAnalyst 4.0 for Comprehensive and Integrative Metabolomics Data Analysis. Curr Protoc Bioinformatics 2019, 68, e86, doi:10.1002/cpbi.86.
26. Xia, J.; Wishart, D.S. Metabolomic data processing, analysis, and interpretation using MetaboAnalyst. Curr Protoc Bioinformatics 2011, Chapter 14, Unit 14 10, doi:10.1002/0471250953.bi1410s34.
27. Fettig, L.M.; McGinn, O.; Finlay-Schultz, J.; LaBarbera, D.V.; Nordeen, S.K.; Sartorius, C.A. Cross talk between progesterone receptors and retinoic acid receptors in regulation of cytokeratin 5-positive breast cancer cells. Oncogene 2017, 36, 6074-6084, doi:10.1038/onc.2017.204.
28. Finlay-Schultz, J.; Gillen, A.E.; Brechbuhl, H.M.; Ivie, J.J.; Matthews, S.B.; Jacobsen, B.M.; Bentley, D.L.; Kabos, P.; Sartorius, C.A. Breast Cancer Suppression by Progesterone Receptors Is Mediated by Their Modulation of Estrogen Receptors and RNA Polymerase III. Cancer Res 2017, 77, 4934-4946, doi:10.1158/0008-5472.CAN-16-3541.
29. Hagan, C.R.; Lange, C.A. Molecular determinants of context-dependent progesterone receptor action in breast cancer. BMC Med 2014, 12, 32, doi:10.1186/1741-7015-12-32.
30. DeBerardinis, R.J.; Lum, J.J.; Hatzivassiliou, G.; Thompson, C.B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008, 7, 11-20, doi:10.1016/j.cmet.2007.10.002.
31. Denechaud, P.D.; Fajas, L.; Giralt, A. E2F1, a Novel Regulator of Metabolism. Front Endocrinol (Lausanne) 2017, 8, 311, doi:10.3389/fendo.2017.00311.
32. Warburg, O. On the origin of cancer cells. Science 1956, 123, 309-314, doi:10.1126/science.123.3191.309.
33. Ge, T.; Yang, J.; Zhou, S.; Wang, Y.; Li, Y.; Tong, X. The Role of the Pentose Phosphate Pathway in Diabetes and Cancer. Front Endocrinol (Lausanne) 2020, 11, 365, doi:10.3389/fendo.2020.00365.
34. Klinge, C.M. Estrogenic control of mitochondrial function and biogenesis. J Cell Biochem 2008, 105, 1342-1351, doi:10.1002/jcb.21936.
35. Avagliano, A.; Ruocco, M.R.; Aliotta, F.; Belviso, I.; Accurso, A.; Masone, S.; Montagnani, S.; Arcucci, A. Mitochondrial Flexibility of Breast Cancers: A Growth Advantage and a Therapeutic Opportunity. Cells 2019, 8, doi:10.3390/cells8050401.
36. Liesa, M.; Shirihai, O.S. Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure. Cell Metab 2013, 17, 491-506, doi:10.1016/j.cmet.2013.03.002.
37. Axlund, S.D.; Sartorius, C.A. Progesterone regulation of stem and progenitor cells in normal and malignant breast. Mol Cell Endocrinol 2012, 357, 71-79, doi:10.1016/j.mce.2011.09.021.
38. Simoes, B.M.; Alferez, D.G.; Howell, S.J.; Clarke, R.B. The role of steroid hormones in breast cancer stem cells. Endocr Relat Cancer 2015, 22, T177-186, doi:10.1530/ERC-15-0350.
39. Horwitz, K.B.; Sartorius, C.A. 90 YEARS OF PROGESTERONE: Progesterone and progesterone receptors in breast cancer: past, present, future. J Mol Endocrinol 2020, 65, T49-T63, doi:10.1530/JME-20-0104.
40. Batlle, E.; Clevers, H. Cancer stem cells revisited. Nat Med 2017, 23, 1124-1134, doi:10.1038/nm.4409.
41. Luo, M.; Shang, L.; Brooks, M.D.; Jiagge, E.; Zhu, Y.; Buschhaus, J.M.; Conley, S.; Fath, M.A.; Davis, A.; Gheordunescu, E.; et al. Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling. Cell Metab 2018, 28, 69-86 e66, doi:10.1016/j.cmet.2018.06.006.
42. Mancini, R.; Noto, A.; Pisanu, M.E.; De Vitis, C.; Maugeri-Sacca, M.; Ciliberto, G. Metabolic features of cancer stem cells: the emerging role of lipid metabolism. Oncogene 2018, 37, 2367-2378, doi:10.1038/s41388-018-0141-3.
43. Fiorillo, M.; Sanchez-Alvarez, R.; Sotgia, F.; Lisanti, M.P. The ER-alpha mutation Y537S confers Tamoxifen-resistance via enhanced mitochondrial metabolism, glycolysis and Rho-GDI/PTEN signaling: Implicating TIGAR in somatic resistance to endocrine therapy. Aging (Albany NY) 2018, 10, 4000-4023, doi:10.18632/aging.101690.
44. Zinger, L.; Merenbakh-Lamin, K.; Klein, A.; Elazar, A.; Journo, S.; Boldes, T.; Pasmanik-Chor, M.; Spitzer, A.; Rubinek, T.; Wolf, I. Ligand-binding Domain-activating Mutations of ESR1 Rewire Cellular Metabolism of Breast Cancer Cells. Clin Cancer Res 2019, 25, 2900-2914, doi:10.1158/1078-0432.CCR-18-1505.
45. Cruceriu, D.; Baldasici, O.; Balacescu, O.; Berindan-Neagoe, I. The dual role of tumor necrosis factor-alpha (TNF-alpha) in breast cancer: molecular insights and therapeutic approaches. Cell Oncol (Dordr) 2020, 43, 1-18, doi:10.1007/s13402-019-00489-1.
46. Benz, C.C. Impact of aging on the biology of breast cancer. Crit Rev Oncol Hematol 2008, 66, 65-74, doi:10.1016/j.critrevonc.2007.09.001.
47. Sahin, S.; Erdem, G.U.; Karatas, F.; Aytekin, A.; Sever, A.R.; Ozisik, Y.; Altundag, K. The association between body mass index and immunohistochemical subtypes in breast cancer. Breast 2017, 32, 227-236, doi:10.1016/j.breast.2016.09.019.
48. Giles, E.D.; Wellberg, E.A.; Astling, D.P.; Anderson, S.M.; Thor, A.D.; Jindal, S.; Tan, A.C.; Schedin, P.S.; Maclean, P.S. Obesity and overfeeding affecting both tumor and systemic metabolism activates the progesterone receptor to contribute to postmenopausal breast cancer. Cancer Res 2012, 72, 6490-6501, doi:10.1158/0008-5472.CAN-12-1653.
49. Chlebowski, R.T.; Anderson, G.L.; Gass, M.; Lane, D.S.; Aragaki, A.K.; Kuller, L.H.; Manson, J.E.; Stefanick, M.L.; Ockene, J.; Sarto, G.E.; et al. Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women. JAMA 2010, 304, 1684-1692, doi:10.1001/jama.2010.1500.
50. Chlebowski, R.T.; Anderson, G.L.; Aragaki, A.K.; Manson, J.E.; Stefanick, M.L.; Pan, K.; Barrington, W.; Kuller, L.H.; Simon, M.S.; Lane, D.; et al. Association of Menopausal Hormone Therapy With Breast Cancer Incidence and Mortality During Long-term Follow-up of the Women's Health Initiative Randomized Clinical Trials. JAMA 2020, 324, 369-380, doi:10.1001/jama.2020.9482.
51. Santen, R.J. Risk of breast cancer with progestins: critical assessment of current data. Steroids 2003, 68, 953-964, doi:S0039128X03001387 [pii].
52. Horwitz, K.B.; Sartorius, C.A. Progestins in hormone replacement therapies reactivate cancer stem cells in women with preexisting breast cancers: a hypothesis. J Clin Endocrinol Metab 2008, 93, 3295-3298, doi:10.1210/jc.2008-0938.
53. Yu, M.; Chen, S.; Hong, W.; Gu, Y.; Huang, B.; Lin, Y.; Zhou, Y.; Jin, H.; Deng, Y.; Tu, L.; et al. Prognostic role of glycolysis for cancer outcome: evidence from 86 studies. J Cancer Res Clin Oncol 2019, 145, 967-999, doi:10.1007/s00432-019-02847-w.