The Little Ice Age (LIA) describes cold conditions that lasted for centuries associated with the expansion of glaciers that could be initiated by a large volcanic eruption. The 1257 eruption of the Samalas volcano caused climatic impacts worldwide and possibly has played a role in starting the LIA. The injected volcanic material was so extraordinary that statistically significant results were obtained. To test whether the Samalas eruption triggered climate change that resulted in LIA, the data used in this study refers to 7 curves of temperature reconstruction in the Northern Hemisphere because they are formed based on multi-proxy data. Furthermore, data processing is carried out in 4 stages, namely selecting the temperature reconstruction curve for the years 1000–2000, digitizing the curve, interpolating, and normalizing the temperature value. The data is then selected first based on the similarity of the shape of the digitization curve, the results of descriptive statistics are in accordance with the LIA periodization, and the results of inferential statistics show that there is no difference in temperature between the data. Based on the results obtained, the trend curve of temperature changes at 50-year intervals from each data group in the Northern Hemisphere can show global climate change due to the Samalas eruption and prove that the eruption of Samalas initiated climate change which resulted in LIA.