Background: The human microbiome is a mixed group of microorganisms and has been verified the relationship between gastrointestinal microbiota and blood pressure. The intestinal microbiota of chronic kidney disease (CKD) patients in the distribution of bacterial species is different from the flora of people with no CKD. The purpose of this research is to study on the different intestinal microbiota of hypertensive patients with and without nephropathy and to find possible bio-markers to diagnose hypertensive nephropathy, as well as one of the basis for hypertensive nephropathy or CKD clinical intervention treatment.
Methods: The study subjects were divided into three groups, normal control, simple hypertension and hypertensive nephropathy. Sequencing, bioinformatics and statistical analysis were performed on the 16S rRNA gene of the flora of the subjects' stool samples.
Results: This research shows the difference of intestinal flora in hypertension patients with and without nephropathy; it investigates the relationship of the differences in the intestinal microbiota with bile-acid metabolism; it also explores bile-acid metabolism mechanism of intestinal microbiota differences of hypertensive with or without nephropathy.
Conclusions: The different gastrointestinal microbiota is related to bile-acid metabolism in hypertensive patients, and can be one of the factors causing CKD.
Trial registration: This article does not report the results of a health care intervention on human participants.