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Research article
Are Topical Skin Adhesives an Option for Wound Closure Following Musculoskeletal Oncology Surgery? A STROCSS-compliant Observational Study
Thanapon Chobpenthai
HRH Princess Chulabhorn College of Medical Science
Corresponding Author
ORCiD: https://orcid.org/0000-0002-2482-8203
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background:
2-octyl cyanoacrylate (2OCA) is a high-viscosity medical-grade tissue adhesive used routinely. However, no studies have evaluated its use in musculoskeletal oncology surgery.
Methods:
We enrolled 99 patients undergoing musculoskeletal oncology surgery. 2OCA was chosen for wound closure, and it was applied by a specific surgeon for all patients. Drying times for the adhesive were recorded, and photographs were obtained intra-operatively. Post-treatment follow-up constituted queries regarding pain level, and recording incisional dehiscence, wound infection, hematoma, and incisional bleeding. Data collection was performed post-operatively at 48 hours, 5–10 days, 14 days, and 30 days. Other adverse events were documented.
Results:
2OCA was applied to 110 incisions in 99 patients constituting 62 female patients and 37 male patients. The mean age of patients was 50.41 (±16.83) years; mean incision length was 10.24 (±5.7) cm; and the mean pain score using a visual analogue scale (VAS) was 2.37 on post-operative day 7. The mean drying time was 1.81 (±0.59) minutes; 91 (91%) patients reported excellent and superior satisfaction, and the remaining patients reported “good” (6%) and “fair” (2%) satisfaction. The percentage of dehiscence, hematoma, and keloid formation was considerably low.
Conclusion:
2OCA was safe in musculoskeletal oncology surgical incisions in this study. The incidence of post-operative adverse events was low. However, some patients developed a hematoma. Post-operative pain was low, and patient satisfaction was high. 2OCA can be a practical alternative to traditional suture closure for skin incisions after musculoskeletal surgery.
Keywords
2-octyl cyanoacrylate, topical skin adhesive, musculoskeletal oncology surgery
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CURRENT STATUS: Under Review
Version 1
Posted 11 Jan, 2021
No community comments so far
Review #1 received
Received 16 Jan, 2021
Reviewer #2 agreed
On 08 Jan, 2021
Review #2 received
Received 08 Jan, 2021
Reviewer #1 agreed
On 07 Jan, 2021
Reviewers invited
Invitations sent on 06 Jan, 2021
Editor assigned
On 05 Jan, 2021
Submission checks complete
On 05 Jan, 2021
Editor invited
On 05 Jan, 2021
First submitted
On 04 Jan, 2021
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Subject Areas
Orthopedic Surgery
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This preprint is under consideration at Journal of Orthopaedic Surgery and Research. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Are Topical Skin Adhesives an Option for Wound Closure Following Musculoskeletal Oncology Surgery? A STROCSS-compliant Observational Study
Thanapon Chobpenthai
HRH Princess Chulabhorn College of Medical Science
Corresponding Author
ORCiD: https://orcid.org/0000-0002-2482-8203
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 11 Jan, 2021
No community comments so far
Review #1 received
Received 16 Jan, 2021
Reviewer #2 agreed
On 08 Jan, 2021
Review #2 received
Received 08 Jan, 2021
Reviewer #1 agreed
On 07 Jan, 2021
Reviewers invited
Invitations sent on 06 Jan, 2021
Editor assigned
On 05 Jan, 2021
Submission checks complete
On 05 Jan, 2021
Editor invited
On 05 Jan, 2021
First submitted
On 04 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Orthopedic Surgery
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background:
2-octyl cyanoacrylate (2OCA) is a high-viscosity medical-grade tissue adhesive used routinely. However, no studies have evaluated its use in musculoskeletal oncology surgery.
Methods:
We enrolled 99 patients undergoing musculoskeletal oncology surgery. 2OCA was chosen for wound closure, and it was applied by a specific surgeon for all patients. Drying times for the adhesive were recorded, and photographs were obtained intra-operatively. Post-treatment follow-up constituted queries regarding pain level, and recording incisional dehiscence, wound infection, hematoma, and incisional bleeding. Data collection was performed post-operatively at 48 hours, 5–10 days, 14 days, and 30 days. Other adverse events were documented.
Results:
2OCA was applied to 110 incisions in 99 patients constituting 62 female patients and 37 male patients. The mean age of patients was 50.41 (±16.83) years; mean incision length was 10.24 (±5.7) cm; and the mean pain score using a visual analogue scale (VAS) was 2.37 on post-operative day 7. The mean drying time was 1.81 (±0.59) minutes; 91 (91%) patients reported excellent and superior satisfaction, and the remaining patients reported “good” (6%) and “fair” (2%) satisfaction. The percentage of dehiscence, hematoma, and keloid formation was considerably low.
Conclusion:
2OCA was safe in musculoskeletal oncology surgical incisions in this study. The incidence of post-operative adverse events was low. However, some patients developed a hematoma. Post-operative pain was low, and patient satisfaction was high. 2OCA can be a practical alternative to traditional suture closure for skin incisions after musculoskeletal surgery.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5